{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:33:24Z","timestamp":1792787604268,"version":"4.5.0"},"reference-count":0,"publisher":"American Society for Clinical Investigation","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH Office of the Director","award":["NIH P51 OD011132"],"award-info":[{"award-number":["NIH P51 OD011132"]}]},{"name":"NIH Office of the Director","award":["NIH S10 OD026799"],"award-info":[{"award-number":["NIH S10 OD026799"]}]},{"name":"National Institute of Neurological Disorders and Stroke","award":["R01 NS120182"],"award-info":[{"award-number":["R01 NS120182"]}],"id":[{"id":"https:\/\/ror.org\/01s5ya894","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Congenital and early-life Zika virus (ZIKV) infection can result in neurologic deficits. Precise mechanisms of injury, especially in the more subtle presentation of postnatal infection, are not fully elucidated. Here, we defined the effects of ZIKV on the developing brain using single cell transcriptomics, histopathology and design-based stereology, diffusion MRI, and neurobehavioral assessments in infant rhesus macaques. ZIKV upregulated interferon-stimulated genes in activated microglia and cell death pathways in neurons and downregulated metabolism and differentiation genes in mature oligodendrocytes. Abnormal micro-organization of the corpus collosum and limbic white matter tracts was seen on diffusion weighted imaging. A curated gene set associated with autism spectrum disorder risk was negatively enriched in inhibitory and excitatory neurons from ZIKV-infected infants, with increased emotional reactivity already evident two weeks following infection. From single cells to organism-level behaviors, these results define the pathways and processes disrupted by early-life ZIKV infection.<\/jats:p>","DOI":"10.1172\/jci.insight.203088","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:01:02Z","timestamp":1790265662000},"source":"Crossref","is-referenced-by-count":0,"title":["Disrupted neuronal expression of autism risk genes and white matter micro-organization after infant Zika infection"],"prefix":"10.1172","author":[{"given":"Venkata-Viswanadh","family":"Edara","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Emory University School of Medicine, Atlanta, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sienna","family":"Freeman","sequence":"additional","affiliation":[{"name":"Emory National Primate Research Center, Atlanta, United States of 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America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divine","family":"Burgess","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Emory University School of Medicine, Atlanta, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle J.","family":"Lee","sequence":"additional","affiliation":[{"name":"Emory National Primate Research Center, Atlanta, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3075-755X","authenticated-orcid":true,"given":"Gregory K.","family":"Tharp","sequence":"additional","affiliation":[{"name":"Emory National Primate Research Center, Atlanta, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roza","family":"Vlasova","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, United States of 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America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther W.","family":"Ndungu","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Howard University, Washington DC, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ava K.","family":"Mascarenhas","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Howard University, Washington DC, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6213-4931","authenticated-orcid":true,"given":"Chao-Hsiung","family":"Hsu","sequence":"additional","affiliation":[{"name":"Molecular Imaging Laboratory, Department of Radiology, Howard University, Washington DC, United States of 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America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Raper","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Emory University School of Medicine, Atlanta, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7479-9546","authenticated-orcid":true,"given":"Ann","family":"Chahroudi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Emory University School of Medicine, Atlanta, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2026,9,24]]},"container-title":["JCI 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