{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:56:10Z","timestamp":1792799770084,"version":"4.5.0"},"reference-count":56,"publisher":"American Society for Clinical Investigation","issue":"14","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":64,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"crossref","award":["UM1 AI 164567-02"],"award-info":[{"award-number":["UM1 AI 164567-02"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Chinese Academy of Medical Sciences  Innovation Fund for Medical Science, China )","award":["(2024-I2M-2-001-1"],"award-info":[{"award-number":["(2024-I2M-2-001-1"]}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"crossref","award":["Scholarship"],"award-info":[{"award-number":["Scholarship"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Control of Emerging and Major Infectious Diseases-National Science and Technology Major Project","award":["2025ZD01904400"],"award-info":[{"award-number":["2025ZD01904400"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82472269"],"award-info":[{"award-number":["82472269"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences","award":["2023-PT320-01"],"award-info":[{"award-number":["2023-PT320-01"]}],"id":[{"id":"https:\/\/ror.org\/02drdmm93","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["32500781"],"award-info":[{"award-number":["32500781"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,22]]},"abstract":"<jats:p>\n                    HLA-E\u2013restricted HIV-specific T cells offer exciting possibilities for immunotherapy. However, HLA-E binding peptides are rare. A recent study showed that in HLA-B*57:01\u2013positive people with HIV, the peptide that dominates the T cell response, KAFSPEVIPMF (KF11), also stimulates HLA-E\u2013restricted T cells, even though direct binding of this peptide to HLA-E could not be demonstrated. We therefore changed position 2 alanine for methionine in the peptide (referred to as KMF11), which greatly enhanced binding to HLA-E. This enabled the generation of stabilized HLA-E-KMF11 tetramers, which were used to select and then grow specific T cell clones from T cells of HLA-B*57:01\u2013negative blood donors primed with this peptide in vitro. Approximately 20% of these T cell clones reacted with HLA-E\u2013positive cells presenting the native KF11 peptide. Furthermore, these T cells inhibited replication of HIV-1 NL4-3 in CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells in vitro. Therefore, this native peptide can be presented by HLA-E to CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells, although priming in vivo may depend on cross-reactivities to classical MHC-Ia types. Nevertheless, such T cells could be exploitable for immunotherapy given the conservation of this HIV-1 peptide epitope and the non-polymorphism in HLA-E.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.203593","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T16:01:48Z","timestamp":1779206508000},"source":"Crossref","is-referenced-by-count":2,"title":["HLA-E\u2013restricted T cells primed by a modified HLA-B*57:01\u2013restricted HIV-1 peptide suppress HIV-1 replication"],"prefix":"10.1172","volume":"11","author":[{"given":"Hong","family":"Sun","sequence":"first","affiliation":[{"name":"Centre for Immuno-Oncology, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom."},{"name":"Chinese Academy of Medical Sciences Oxford Institute, Oxford, United Kingdom."},{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, NHC Key Laboratory of AIDS Prevention and Treatment, National Clinical Research Center for Laboratory Medicine, The First Hospital of China Medical University, China Medical University, Shenyang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbing","family":"Yang","sequence":"additional","affiliation":[{"name":"Centre for Immuno-Oncology, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom."},{"name":"Chinese Academy of Medical Sciences Oxford Institute, Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max N.","family":"Quastel","sequence":"additional","affiliation":[{"name":"Centre for Immuno-Oncology, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Brackenridge","sequence":"additional","affiliation":[{"name":"Centre for Immuno-Oncology, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanlin","family":"He","sequence":"additional","affiliation":[{"name":"Centre for Immuno-Oncology, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom."},{"name":"State Key Laboratory of Oral Diseases and National Center for Stomatology and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna E.","family":"Kliszczak","sequence":"additional","affiliation":[{"name":"Centre for Immuno-Oncology, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarida","family":"Rei","sequence":"additional","affiliation":[{"name":"Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal."},{"name":"Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3877-9780","authenticated-orcid":true,"given":"Persephone","family":"Borrow","sequence":"additional","affiliation":[{"name":"Centre for Immuno-Oncology, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geraldine M.","family":"Gillespie","sequence":"additional","affiliation":[{"name":"Centre for Immuno-Oncology, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9101-7478","authenticated-orcid":true,"given":"Andrew J.","family":"McMichael","sequence":"additional","affiliation":[{"name":"Centre for Immuno-Oncology, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom."},{"name":"Chinese Academy of Medical Sciences Oxford Institute, Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2026,5,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/35869"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20020609"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000782"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004671"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-54378-9"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900795"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abl8881"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.112680099"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2025.116181"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-025-01218-6"},{"key":"B11","unstructured":"UNAIDS. UNAIDS data 2024. https:\/\/www.unaids.org\/en\/resources\/documents\/2024\/2024_unaids_data Updated December 2, 2024. Accessed June 22, 2026"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0858-8"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0000000000000824"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-024-00818-y"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/nature12519"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1126\/science.aac9475"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2022.07.013"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abg1703"},{"key":"B19","doi-asserted-by":"crossref","unstructured":"Hwang JK, et al. HLA-E-VL9 antibodies enhance NK cell and CD8 + T cell cytotoxicity against HIV-infected CD4 + T cells [preprint]. https:\/\/doi.org\/10.1101\/2024.07.08.602401 Posted on bioRxiv May 14, 2025","DOI":"10.1101\/2024.07.08.602401"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1172\/JCI148979"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.4.2459"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200205030-00002"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1998.tb01192.x"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05459-z"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202048719"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-12-326231"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1207896109"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.6.3893"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.807719"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.110959"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202149745"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/nature08997"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2342"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01580-06"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.10.6130"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.58128"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201242606"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2011.03515.x"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200636765"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M500555200"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700242"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01378"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.9.5727"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20101574"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2008.02848.x"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2172-12-40"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-024-02044-z"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.10.6334"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1046\/j.1600-065X.2003.00083.x"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.03.005"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1038\/nature07657"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-22-0761"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.1.270"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-5008"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-082223-035718"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2012.07.009"}],"container-title":["JCI Insight"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/insight.jci.org\/articles\/view\/203593\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T12:33:35Z","timestamp":1784896415000},"score":1,"resource":{"primary":{"URL":"https:\/\/insight.jci.org\/articles\/view\/203593"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,19]]},"references-count":56,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2026,7,22]]},"published-print":{"date-parts":[[2026,7,22]]}},"alternative-id":["10.1172\/jci.insight.203593"],"URL":"https:\/\/doi.org\/10.1172\/jci.insight.203593","relation":{},"ISSN":["2379-3708"],"issn-type":[{"value":"2379-3708","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,19]]},"article-number":"e203593"}}