{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T04:10:24Z","timestamp":1789186224795,"version":"build-2803163510"},"reference-count":33,"publisher":"American Society for Clinical Investigation","issue":"12","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":48,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NA","award":["NA"],"award-info":[{"award-number":["NA"]}]},{"name":"NIH","award":["R01 CA244899"],"award-info":[{"award-number":["R01 CA244899"]}]},{"name":"NIH","award":["R01 CA252222"],"award-info":[{"award-number":["R01 CA252222"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,22]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Chimeric antigen receptor T-cell (CAR-T) therapies have revolutionized treatment for relapsed\/refractory multiple myeloma (RRMM). However, cytokine release syndrome (CRS), a common and potentially severe complication, requires inpatient monitoring, limiting access and increasing costs. Wearable devices could support outpatient CAR-T delivery, but feasibility for CRS detection versus standard care remains unproven.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We conducted a prospective, single-center observational pilot study to assess the feasibility of using wearable devices for monitoring vital signs and detecting CRS. Thirty patients receiving idecabtagene vicleucel (ide-cel) or ciltacabtagene autoleucel (cilta-cel) were enrolled; 25 with sufficient monitoring data were evaluable. Sensors collected skin and axillary temperature, oxygen saturation, respiratory and heart rate, and motion. Peripheral blood cytokines were analyzed pre- and postinfusion using a multiplex proteomic platform. The primary outcome was feasibility, assessed by CRS detection sensitivity and specificity; secondary outcomes included adherence, lead time, and performance of models integrating wearable and cytokine data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>CRS occurred in 20 of 25 patients. The best-performing wearable model detected 18 or 20 CRS episodes with a sensitivity of 0.72 (mean 0.75; 95% CI 0.60\u20130.91) and a specificity of 0.80 (mean 0.76; 95% CI 0.68\u20130.84), and a median lead time of 7:00 hours before nursing recognition. Median adherence during high-risk periods was 71%. Cytokine changes paralleled temperature elevations, and IFN-\u03b3 emerged as a consistent biomarker.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Wearable devices are feasible for early CRS detection and may support outpatient CAR-T care. Larger outpatient studies are warranted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>TRIAL REGISTRATION<\/jats:title>\n                    <jats:p>This study did not meet the criteria for ClinicalTrials.gov registration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1172\/jci.insight.203988","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T16:01:23Z","timestamp":1777996883000},"source":"Crossref","is-referenced-by-count":1,"title":["Detection of cytokine release syndrome using wearables and cytokine profiling following CAR-T therapy for myeloma"],"prefix":"10.1172","volume":"11","author":[{"given":"Sridevi","family":"Rajeeve","sequence":"first","affiliation":[{"name":"Myeloma & Cellular Therapy Services, Memorial Sloan Kettering Cancer Center, New York, New York, 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