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Imaging data correlated with significantly decreased tumor interstitial fluid pressure, while tumor vascular density remained unchanged. This immediately clinically translatable concept involving Alk5 inhibitor pretreatment prior to an imaging study could be leveraged for improved tumor delivery of macromolecular and nanoparticle-based imaging probes and, thereby, facilitate development of more sensitive imaging tests for cancer diagnosis, enhanced tumor characterization, and personalized, image-guided therapies.<\/jats:p>","DOI":"10.1172\/jci.insight.85608","type":"journal-article","created":{"date-parts":[[2016,5,4]],"date-time":"2016-05-04T11:07:07Z","timestamp":1462360027000},"source":"Crossref","is-referenced-by-count":15,"title":["Alk5 inhibition increases delivery of macromolecular and protein-bound contrast agents to tumors"],"prefix":"10.1172","volume":"1","author":[{"given":"Heike E.","family":"Daldrup-Link","sequence":"first","affiliation":[{"name":"Department of Radiology, Molecular Imaging Program at Stanford (MIPS), Stanford University, Stanford, California, 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