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ALDH1 is also upregulated in the mucosa of the mouse model of scarring allergic eye disease (AED), used here as a surrogate for OMMP, in which topical application of disulfiram decreased fibrosis in vivo. These data suggest that progressive scarring in OMMP results from ALDH\/RA fibroblast autoregulation, that the ALDH1 subfamily has a central role in immune-mediated ocular mucosal scarring, and that ALDH inhibition with disulfiram is a potential and readily translatable antifibrotic therapy.<\/jats:p>","DOI":"10.1172\/jci.insight.87001","type":"journal-article","created":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T11:00:34Z","timestamp":1470222034000},"source":"Crossref","is-referenced-by-count":45,"title":["Aldehyde dehydrogenase inhibition blocks mucosal fibrosis in human and mouse ocular scarring"],"prefix":"10.1172","volume":"1","author":[{"given":"Sarah D.","family":"Ahadome","sequence":"first","affiliation":[{"name":"Ocular Biology and Therapeutics, UCL Institute of Ophthalmology, London, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Abraham","sequence":"additional","affiliation":[{"name":"Centre for Rheumatology and 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