{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T23:51:56Z","timestamp":1788997916828,"version":"build-2803163510"},"reference-count":69,"publisher":"American Society for Clinical Investigation","issue":"20","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,12,8]]},"abstract":"<jats:p>\n                    Psoriasis patients are at increased risk of heart attack and stroke and have elevated MRP8\/14 levels that predict heart attack. The KC-Tie2 psoriasiform mouse model exhibits elevated MRP8\/14 and is prothrombotic.\n                    <jats:italic>Mrp14<\/jats:italic>\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    mice, in contrast, are protected from thrombosis, but, surprisingly, KC-Tie2x\n                    <jats:italic>Mrp14<\/jats:italic>\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    mice remain prothrombotic. Treating KC-Tie2x\n                    <jats:italic>Mrp14<\/jats:italic>\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    mice with anti\u2013IL-23p19 antibodies reversed the skin inflammation, improved thrombosis, and decreased IL-6. In comparison, IL-6 deletion from KC-Tie2 animals improved thrombosis despite sustained skin inflammation, suggesting that thrombosis improvements following IL-23 inhibition occur secondary to IL-6 decreases. Psoriasis patient skin has elevated IL-6 and IL-6 receptor is present in human coronary atheroma, supporting a link between skin and distant vessel disease in patient tissue. Together, these results identify a critical role for skin-derived IL-6 linking skin inflammation with thrombosis, and shows that in the absence of IL-6 the connection between skin inflammation and thrombosis comorbidities is severed.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.89384","type":"journal-article","created":{"date-parts":[[2016,12,7]],"date-time":"2016-12-07T11:00:58Z","timestamp":1481108458000},"source":"Crossref","is-referenced-by-count":35,"title":["Interleukin 6 regulates psoriasiform inflammation\u2013associated thrombosis"],"prefix":"10.1172","volume":"1","author":[{"given":"Yunmei","family":"Wang","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, Ohio, USA,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackelyn B.","family":"Golden","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Case 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