{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:02:46Z","timestamp":1790791366620,"version":"4.1.0"},"reference-count":55,"publisher":"American Society for Clinical Investigation","issue":"17","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,10,20]]},"abstract":"<jats:p>\n                    Adaptive changes in the genome of a locally predominant clinical isolate of the multidrug-resistant\n                    <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                    ST258 (KP35) were identified and help to explain the selection of this strain as a successful pulmonary pathogen. The acquisition of 4 new ortholog groups, including an arginine transporter, enabled KP35 to outcompete related ST258 strains lacking these genes. KP35 infection elicited a monocytic response, dominated by Ly6C\n                    <jats:sup>hi<\/jats:sup>\n                    monocytic myeloid-derived suppressor cells that lacked phagocytic capabilities, expressed IL-10, arginase, and antiinflammatory surface markers. In comparison with other\n                    <jats:italic>K<\/jats:italic>\n                    .\n                    <jats:italic>pneumoniae<\/jats:italic>\n                    strains, KP35 induced global changes in the phagocytic response identified with proteomics, including evasion of Ca\n                    <jats:sup>2+<\/jats:sup>\n                    and calpain activation necessary for phagocytic killing, confirmed in functional studies with neutrophils. This comprehensive analysis of an ST258\n                    <jats:italic>K<\/jats:italic>\n                    .\n                    <jats:italic>pneumoniae<\/jats:italic>\n                    isolate reveals ongoing genetic adaptation to host microenvironments and innate immune clearance mechanisms that complements its repertoire of antimicrobial resistance genes and facilitates persistence in the lung.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.89704","type":"journal-article","created":{"date-parts":[[2016,10,19]],"date-time":"2016-10-19T11:00:59Z","timestamp":1476874859000},"source":"Crossref","is-referenced-by-count":59,"title":["Acquired resistance to innate immune clearance promotes Klebsiella pneumoniae ST258 pulmonary infection"],"prefix":"10.1172","volume":"1","author":[{"given":"Danielle","family":"Ahn","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Columbia University Medical Center, New York, New York, 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