{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:40:53Z","timestamp":1790487653752,"version":"4.1.0"},"reference-count":111,"publisher":"American Society for Clinical Investigation","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1,26]]},"abstract":"<jats:p>\n                    The sympathetic nervous system (SNS) accelerates heart rate, increases cardiac contractility, and constricts resistance vessels. The activity of SNS efferent nerves is generated by a complex neural network containing neurons and glia. Gq G protein\u2013coupled receptor (Gq-GPCR) signaling in glial fibrillary acidic protein\u2013expressing (GFAP\n                    <jats:sup>+<\/jats:sup>\n                    ) glia in the central nervous system supports neuronal function and regulates neuronal activity. It is unclear how Gq-GPCR signaling in GFAP\n                    <jats:sup>+<\/jats:sup>\n                    glia affects the activity of sympathetic neurons or contributes to SNS-regulated cardiovascular functions. In this study, we investigated whether Gq-GPCR activation in GFAP\n                    <jats:sup>+<\/jats:sup>\n                    glia modulates the regulatory effect of the SNS on the heart; transgenic mice expressing Gq-coupled DREADD (designer receptors exclusively activated by designer drugs) (hM3Dq) selectively in GFAP\n                    <jats:sup>+<\/jats:sup>\n                    glia were used to address this question in vivo. We found that acute Gq-GPCR activation in peripheral GFAP\n                    <jats:sup>+<\/jats:sup>\n                    glia significantly accelerated heart rate and increased left ventricle contraction. Pharmacological experiments suggest that the glial-induced cardiac changes were due to Gq-GPCR activation in satellite glial cells within the sympathetic ganglion; this activation led to increased norepinephrine (NE) release and beta-1 adrenergic receptor activation within the heart. Chronic glial Gq-GPCR activation led to hypotension in female\n                    <jats:italic>Gfap<\/jats:italic>\n                    -hM3Dq mice. This study provides direct evidence that Gq-GPCR activation in peripheral GFAP\n                    <jats:sup>+<\/jats:sup>\n                    glia regulates cardiovascular functions in vivo.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.90565","type":"journal-article","created":{"date-parts":[[2017,1,25]],"date-time":"2017-01-25T11:01:10Z","timestamp":1485342070000},"source":"Crossref","is-referenced-by-count":38,"title":["Ganglionic GFAP+ glial Gq-GPCR signaling enhances heart functions in vivo"],"prefix":"10.1172","volume":"2","author":[{"given":"Alison Xiaoqiao","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakovin J.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken 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