{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:43:06Z","timestamp":1790800986880,"version":"4.1.0"},"reference-count":71,"publisher":"American Society for Clinical Investigation","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,2,23]]},"abstract":"<jats:p>\n                    SIV DNA can be detected in lymphoid tissue\u2013resident macrophages of chronically SIV-infected Asian macaques. These macrophages also contain evidence of recently phagocytosed SIV-infected CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells. Here, we examine whether these macrophages contain replication-competent virus, whether viral DNA can be detected in tissue-resident macrophages from antiretroviral (ARV) therapy\u2013treated animals and humans, and how the viral sequences amplified from macrophages and contemporaneous CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells compare. In ARV-naive animals, we find that lymphoid tissue\u2013resident macrophages contain replication-competent virus if they also contain viral DNA in ARV-naive Asian macaques. The genetic sequence of the virus within these macrophages is similar to those within CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells from the same anatomic sites. In ARV-treated animals, we find that viral DNA can be amplified from lymphoid tissue\u2013resident macrophages of SIV-infected Asian macaques that were treated with ARVs for at least 5 months, but we could not detect replication-competent virus from macrophages of animals treated with ARVs. Finally, we could not detect viral DNA in alveolar macrophages from HIV-infected individuals who received ARVs for 3 years and had undetectable viral loads. These data demonstrate that macrophages can contain replication-competent virus, but may not represent a significant reservoir for HIV in vivo.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.91214","type":"journal-article","created":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T15:32:21Z","timestamp":1487259141000},"source":"Crossref","is-referenced-by-count":71,"title":["Tissue-resident macrophages can contain replication-competent virus in antiretroviral-naive, SIV-infected Asian macaques"],"prefix":"10.1172","volume":"2","author":[{"given":"Sarah R.","family":"DiNapoli","sequence":"first","affiliation":[{"name":"Laboratory of Parasitic Diseases,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra M.","family":"Ortiz","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitic Diseases,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Wu","sequence":"additional","affiliation":[{"name":"Laboratory of 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