{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T06:22:58Z","timestamp":1793946178533,"version":"4.8.0"},"reference-count":45,"publisher":"American Society for Clinical Investigation","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,4,6]]},"abstract":"<jats:p>\n                    Surgery can induce cognitive decline, a risk that increases with advancing age. In rodents, postoperative cognitive decline (POCD) is associated with the inflammatory activation of hippocampal microglia. To examine the role of microglia in POCD, we inhibited the colony-stimulating factor 1 receptor (CSF1R) in adult mice, effectively depleting CNS microglia. Surgical trauma (tibial fracture) reduced the ability of mice to remember a conditioned response learned preoperatively, a deficit more pronounced and persistent in mice with diet-induced obesity (DIO). Whereas microglial depletion by itself did not affect learning or memory, perioperative microglial depletion remarkably protected mice, including those with DIO, from POCD. This protection was associated with reduced hippocampal levels of inflammatory mediators, abrogation of hippocampal recruitment of CCR2\n                    <jats:sup>+<\/jats:sup>\n                    leukocytes, and higher levels of circulating inflammation-resolving factors. Targeting microglia may thus be a viable strategy to mitigate the development of POCD, particularly in those with increased vulnerability.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.91229","type":"journal-article","created":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T22:24:53Z","timestamp":1491517493000},"source":"Crossref","is-referenced-by-count":347,"title":["Microglia mediate postoperative hippocampal inflammation and cognitive decline in mice"],"prefix":"10.1172","volume":"2","author":[{"given":"Xiaomei","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Anesthesia and Perioperative Care,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Valdearcos","sequence":"additional","affiliation":[{"name":"The Diabetes Center,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Perioperative Care,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Lutrin","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Perioperative Care,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mervyn","family":"Maze","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Perioperative Care,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suneil K.","family":"Koliwad","sequence":"additional","affiliation":[{"name":"The Diabetes Center,"},{"name":"Department of Medicine, University of California, San Francisco, San Francisco, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2017,4,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e318195b569"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2016.04.071"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldt006"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-016-0681-9"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1126\/science.aag2590"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200703000-00007"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22082"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1014557107"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2008.06.004"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.2174\/1871530315666150316120920"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22664"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000045"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3182834d94"},{"issue":"1","key":"B14","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/nn.3599","article-title":"Identification of a unique TGF-\u03b2-dependent molecular and functional signature in microglia","volume":"17","author":"Butovsky","year":"2014","journal-title":"Nat Neurosci"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021014-071656"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2016.03.013"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.20219"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.02.040"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026317"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1126\/science.1194637"},{"key":"B21","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-015-0366-9","article-title":"Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice","volume":"12","author":"Dagher","year":"2015","journal-title":"J Neuroinflammation"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.11.018"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2016.07.003"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e318286d0c9"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1101\/lm.041400.115"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.03.010"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(92)90087-2"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2010.06.008"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1097\/01.anes.0000296071.19434.1e"},{"issue":"3","key":"B30","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1152\/physrev.2003.83.3.835","article-title":"Regulation of wound healing by growth factors and cytokines","volume":"83","author":"Werner","year":"2003","journal-title":"Physiol Rev"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.5551\/jat.33928"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2016.04.074"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1002\/glia.10161"},{"issue":"3","key":"B34","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1111\/j.1750-3639.2001.tb00401.x","article-title":"Crosstalk between components of the blood brain barrier and cells of the CNS in microglial activation in AIDS","volume":"11","author":"Langford","year":"2001","journal-title":"Brain Pathol"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2297"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.10.006"},{"key":"B37","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.2119\/molmed.2012.00351","article-title":"Dysfunction of inflammation-resolving pathways is associated with exaggerated postoperative cognitive decline in a rat model of the metabolic syndrome","volume":"18","author":"Su","year":"2013","journal-title":"Mol Med"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.2337\/db15-0982"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1002482"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-016-0540-8"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2013.01.051"},{"key":"B42","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1097\/BOT.0000000000000062","article-title":"Modulation of macrophage activity during fracture repair has differential effects in young adult and elderly mice","volume":"28 Suppl 1","author":"Slade Shantz","year":"2014","journal-title":"J Orthop Trauma"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nov245"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1411366"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2016.231"}],"container-title":["JCI Insight"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/insight.jci.org\/articles\/view\/91229\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T13:50:35Z","timestamp":1779198635000},"score":1,"resource":{"primary":{"URL":"https:\/\/insight.jci.org\/articles\/view\/91229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,6]]},"references-count":45,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2017,4,6]]},"published-print":{"date-parts":[[2017,4,6]]}},"alternative-id":["10.1172\/jci.insight.91229"],"URL":"https:\/\/doi.org\/10.1172\/jci.insight.91229","relation":{},"ISSN":["2379-3708"],"issn-type":[{"value":"2379-3708","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,6]]},"article-number":"e91229"}}