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The limited data available on vaccine efficacy in this setting have been derived from rituximab-treated patients receiving concomitant chemotherapy or other potent immunosuppressants. Here, we present an in-depth analysis of seasonal influenza vaccine responses in AIBD patients previously treated with rituximab, who generally did not receive additional therapeutic interventions. We found that, despite a lack of influenza-specific memory B cells in the blood, patients mount robust recall responses to vaccination, comparable to healthy controls, both at a cellular and a serological level. Repertoire analyses of plasmablast responses suggest that they likely derive from a diverse pool of tissue-resident memory cells, refractory to depletion. Overall, these data have important implications for establishing an effective vaccine schedule for AIBD patients and the clinical care of rituximab-treated patients in general and contribute to our basic understanding of maintenance of normal and pathogenic human B cell memory.<\/jats:p>","DOI":"10.1172\/jci.insight.93222","type":"journal-article","created":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T11:01:09Z","timestamp":1497438069000},"source":"Crossref","is-referenced-by-count":60,"title":["Robust memory responses against influenza vaccination in pemphigus patients previously treated with rituximab"],"prefix":"10.1172","volume":"2","author":[{"given":"Alice","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Infectious Disease,"},{"name":"Emory Vaccine Center, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bridget","family":"Bradley","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Kauffman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Infectious Disease,"},{"name":"Emory Vaccine Center, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalita","family":"Priyamvada","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Infectious Disease,"},{"name":"Emory Vaccine Center, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2396-7962","authenticated-orcid":true,"given":"Yevgeniy","family":"Kovalenkov","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Infectious Disease,"},{"name":"Emory Vaccine Center, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Feldman","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Wrammert","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Infectious Disease,"},{"name":"Emory Vaccine Center, and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2017,6,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.11.1333"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.2.179"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(09)70175-6"},{"issue":"21","key":"B4","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1001\/jama.1994.03520210045030","article-title":"The efficacy of influenza vaccination in elderly individuals. 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