{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T02:46:22Z","timestamp":1792896382433,"version":"4.5.0"},"reference-count":77,"publisher":"American Society for Clinical Investigation","issue":"5","funder":[{"name":"American Gastroenterological Association (AGA) and Gastric Cancer Foundation","award":["Grant N017489 (El-Zaatari)"],"award-info":[{"award-number":["Grant N017489 (El-Zaatari)"]}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"crossref","award":["5P30DK034933 (Owyang)"],"award-info":[{"award-number":["5P30DK034933 (Owyang)"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"crossref","award":["R01 DK087708 (Kao)"],"award-info":[{"award-number":["R01 DK087708 (Kao)"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]},{"name":"U.S. Department of Defense","award":["CA160431 (El-Zaatari)"],"award-info":[{"award-number":["CA160431 (El-Zaatari)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,12]]},"abstract":"<jats:p>\n                    Development of gastric cancer is often preceded by chronic inflammation, but the immune cellular mechanisms underlying this process are unclear. Here we demonstrated that an inflammasome molecule, absent in melanoma 2 (Aim2), was upregulated in patients with gastric cancer and in spasmolytic polypeptide-expressing metaplasia of chronically\n                    <jats:italic>Helicobacter felis<\/jats:italic>\n                    \u2013infected stomachs in mice. However, we found that Aim2 was not necessary for inflammasome function during gastritis. In contrast, Aim2 deficiency led to an increase in gastric CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell frequency, which exacerbated metaplasia. These gastric CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells from Aim2\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    mice were found to have lost their homing receptor expression (sphingosine-1-phosphate receptor 1 [S1PR1] and CD62L), a feature of tissue-resident memory T cells. The process was not mediated by Aim2-dependent regulation of IFN-\u03b2 or by dendritic cell\u2013intrinsic Aim2. Rather, Aim2 deficiency contributed to an increased production of CXCL16 by B cells, which could suppress S1PR1 and CD62L in CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells. This study describes a potentially novel function of Aim2 that regulates CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell infiltration and retention within chronically inflamed solid organ tissue. This function operates independent of the inflammasome, IFN-\u03b2, or dendritic cells. We provide evidence that B cells can contribute to this mechanism via CXCL16.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.94035","type":"journal-article","created":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T12:01:26Z","timestamp":1581595286000},"source":"Crossref","is-referenced-by-count":49,"title":["Aim2-mediated\/IFN-\u03b2\u2013independent regulation of gastric metaplastic lesions via CD8+ T cells"],"prefix":"10.1172","volume":"5","author":[{"given":"Mohamad","family":"El-Zaatari","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shrinivas","family":"Bishu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of 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