{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:56:10Z","timestamp":1792799770057,"version":"4.5.0"},"reference-count":50,"publisher":"American Society for Clinical Investigation","issue":"19","funder":[{"name":"Comit\u00e9s D\u00e9partementaux of Loire-Atlantique, Maine et Loire, Vend\u00e9e and Finist\u00e8re from the Ligue Nationale contre le Cancer","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"name":"Canc\u00e9rop\u00f4le Grand Ouest and R\u00e9gion Pays de la Loire","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"https:\/\/ror.org\/03vx94b97","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Canc\u00e9rop\u00f4le Grand Ouest and R\u00e9gion Centre","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"https:\/\/ror.org\/03vx94b97","id-type":"ROR","asserted-by":"crossref"}]},{"name":"NIH","award":["P50GM085273"],"award-info":[{"award-number":["P50GM085273"]}]},{"name":"Academic Science Education and Research Training-Institutional Research and Academic Career Development Award","award":["NIGMS K12 GM088021"],"award-info":[{"award-number":["NIGMS K12 GM088021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,10,5]]},"abstract":"<jats:p>\n                    Subsets of mature B cell neoplasms are linked to infection with intracellular pathogens such as Epstein-Barr virus (EBV), hepatitis C virus (HCV), or\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    . However, the association between infection and the immunoglobulin-secreting (Ig-secreting) B proliferative disorders remains largely unresolved. We investigated whether the monoclonal IgG (mc IgG) produced by patients diagnosed with monoclonal gammopathy of undetermined significance (MGUS) or multiple myeloma (MM) targets infectious pathogens. Antigen specificity of purified mc IgG from a large patient cohort (\n                    <jats:italic>n<\/jats:italic>\n                    = 244) was determined using a multiplex infectious-antigen array (MIAA), which screens for reactivity to purified antigens or lysates from 9 pathogens. Purified mc IgG from 23.4% of patients (57 of 244) specifically recognized 1 pathogen in the MIAA. EBV was the most frequent target (15.6%), with 36 of 38 mc IgGs recognizing EBV nuclear antigen-1 (EBNA-1). MM patients with EBNA-1\u2013specific mc IgG (14.0%) showed substantially greater bone marrow plasma cell infiltration and higher \u03b2\n                    <jats:sub>2<\/jats:sub>\n                    -microglobulin and inflammation\/infection\u2013linked cytokine levels compared with other smoldering myeloma\/MM patients. Five other pathogens were the targets of mc IgG: herpes virus simplex-1 (2.9%), varicella zoster virus (1.6%), cytomegalovirus (0.8%), hepatitis C virus (1.2%), and\n                    <jats:italic>H<\/jats:italic>\n                    .\n                    <jats:italic>pylori<\/jats:italic>\n                    (1.2%). We conclude that a dysregulated immune response to infection may underlie disease onset and\/or progression of MGUS and MM for subsets of patients.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.95367","type":"journal-article","created":{"date-parts":[[2017,10,4]],"date-time":"2017-10-04T11:00:45Z","timestamp":1507114845000},"source":"Crossref","is-referenced-by-count":40,"title":["Monoclonal IgG in MGUS and multiple myeloma targets infectious pathogens"],"prefix":"10.1172","volume":"2","author":[{"given":"Adrien","family":"Bosseboeuf","sequence":"first","affiliation":[{"name":"CRCINA, Inserm, Universit\u00e9 de Nantes, Nantes, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Feron","sequence":"additional","affiliation":[{"name":"CRCINA, Inserm, Universit\u00e9 de Nantes, Nantes, 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Universit\u00e9 Paris 6, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Caillot","sequence":"additional","affiliation":[{"name":"Clinical Hematology, CHU Dijon, Dijon, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Moreau","sequence":"additional","affiliation":[{"name":"Hematology Department, CHU Nantes, Nantes, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Card\u00f3-Vila","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine, Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA."},{"name":"University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Pasqualini","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine, Department of Internal 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