{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T22:38:10Z","timestamp":1793140690635,"version":"4.5.0"},"reference-count":33,"publisher":"American Society for Clinical Investigation","issue":"20","funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"crossref","award":["Morris K. Udall Center of Excellence for Parkinson\u2019s Disease Research at The Feinstein Institute for Medical Research (P50 NS071675 to D.E.)"],"award-info":[{"award-number":["Morris K. Udall Center of Excellence for Parkinson\u2019s Disease Research at The Feinstein Institute for Medical Research (P50 NS071675 to D.E.)"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,10,19]]},"abstract":"<jats:p>\n                    In a rodent model of Parkinson\u2019s disease (PD), levodopa-induced involuntary movements have been linked to striatal angiogenesis \u2014 a process that is difficult to document in living human subjects. Angiogenesis can be accompanied by localized increases in cerebral blood flow (CBF) responses to hypercapnia. We therefore explored the possibility that, in the absence of levodopa, local hypercapnic CBF responses are abnormally increased in PD patients with levodopa-induced dyskinesias (LID) but not in their nondyskinetic (NLID) counterparts. We used H\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>15<\/jats:sup>\n                    O PET to scan 24 unmedicated PD subjects (12 LID and 12 NLID) and 12 matched healthy subjects in the rest state under normocapnic and hypercapnic conditions. Hypercapnic CBF responses were compared to corresponding levodopa responses from the same subjects. Group differences in hypercapnic vasoreactivity were significant only in the posterior putamen, with greater CBF responses in LID subjects compared with the other subjects. Hypercapnic and levodopa-mediated CBF responses measured in this region exhibited distinct associations with disease severity: the former correlated with off-state motor disability ratings but not symptom duration, whereas the latter correlated with symptom duration but not motor disability. These are the first in vivo human findings linking LID to microvascular changes in the basal ganglia.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.96411","type":"journal-article","created":{"date-parts":[[2017,10,18]],"date-time":"2017-10-18T11:00:36Z","timestamp":1508324436000},"source":"Crossref","is-referenced-by-count":21,"title":["Increased putamen hypercapnic vasoreactivity in levodopa-induced dyskinesia"],"prefix":"10.1172","volume":"2","author":[{"given":"Vincent A.","family":"Jourdain","sequence":"first","affiliation":[{"name":"Center for Neurosciences, Feinstein Institute for Medical Research, Manhasset, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5643-556X","authenticated-orcid":true,"given":"Katharina A.","family":"Schindlbeck","sequence":"additional","affiliation":[{"name":"Center for Neurosciences, Feinstein Institute for Medical Research, Manhasset, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris C.","family":"Tang","sequence":"additional","affiliation":[{"name":"Center for Neurosciences, Feinstein Institute for Medical Research, Manhasset, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Niethammer","sequence":"additional","affiliation":[{"name":"Center for Neurosciences, Feinstein Institute for Medical Research, Manhasset, New York, USA."},{"name":"Department of Neurology, Northwell Health, Manhasset, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon Young","family":"Choi","sequence":"additional","affiliation":[{"name":"Center for Neurosciences, Feinstein Institute for Medical Research, Manhasset, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Markowitz","sequence":"additional","affiliation":[{"name":"Hofstra Northwell School of Medicine, Hempstead, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Nazem","sequence":"additional","affiliation":[{"name":"Center for Neurosciences, Feinstein Institute for Medical Research, Manhasset, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic","family":"Nardi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Northwell Health, Manhasset, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Carras","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Northwell Health, Manhasset, New York, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Feigin","sequence":"additional","affiliation":[{"name":"Center for Neurosciences, Feinstein Institute for Medical Research, Manhasset, New York, USA."},{"name":"Department of Neurology, Northwell Health, Manhasset, New York, 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Angiogenesis. In: Granger DN, Granger JP, eds. Colloquium Series on Integrated Systems Physiology: From Molecule to Function to Disease. 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