{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:21:04Z","timestamp":1790256064851,"version":"4.1.0"},"reference-count":63,"publisher":"American Society for Clinical Investigation","issue":"14","funder":[{"DOI":"10.13039\/501100008211","name":"Association France Parkinson","doi-asserted-by":"crossref","award":["131555"],"award-info":[{"award-number":["131555"]}],"id":[{"id":"10.13039\/501100008211","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"crossref","award":["BrainCAV 292222"],"award-info":[{"award-number":["BrainCAV 292222"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"crossref","award":["Brain Vector 2860"],"award-info":[{"award-number":["Brain Vector 2860"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"crossref"}]},{"name":"University of Montpellier, France","award":["DOTATIONRS09"],"award-info":[{"award-number":["DOTATIONRS09"]}]},{"name":"Labex Epigenmed, France","award":["ANR-10-LABX-12-01"],"award-info":[{"award-number":["ANR-10-LABX-12-01"]}]},{"name":"Region Languedoc-Roussillon, France","award":["052276"],"award-info":[{"award-number":["052276"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,7,26]]},"abstract":"<jats:p>\n                    Parkinson\u2019s disease (PD) is the second most prevalent neurodegenerative disease among the elderly. To understand its pathogenesis and to test therapies, animal models that faithfully reproduce key pathological PD hallmarks are needed. As a prelude to developing a model of PD, we tested the tropism, efficacy, biodistribution, and transcriptional effect of canine adenovirus type 2 (CAV-2) vectors in the brain of\n                    <jats:italic>Microcebus<\/jats:italic>\n                    <jats:italic>murinus<\/jats:italic>\n                    , a nonhuman primate that naturally develops neurodegenerative lesions. We show that introducing helper-dependent (HD) CAV-2 vectors results in long-term, neuron-specific expression at the injection site and in afferent nuclei. Although HD CAV-2 vector injection induced a modest transcriptional response, no significant adaptive immune response was generated. We then generated and tested HD CAV-2 vectors expressing leucine-rich repeat kinase 2 (LRRK2) and LRRK2 carrying a G2019S mutation (LRRK2\n                    <jats:sup>G2019S<\/jats:sup>\n                    ), which is linked to sporadic and familial autosomal dominant forms of PD. We show that HD-LRRK2\n                    <jats:sup>G2019S<\/jats:sup>\n                    expression induced parkinsonian-like motor symptoms and histological features in less than 4 months.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.98202","type":"journal-article","created":{"date-parts":[[2018,7,25]],"date-time":"2018-07-25T11:01:04Z","timestamp":1532516464000},"source":"Crossref","is-referenced-by-count":30,"title":["Exogenous LRRK2G2019S induces parkinsonian-like pathology in a nonhuman primate"],"prefix":"10.1172","volume":"3","author":[{"given":"Nadine","family":"Mestre-Franc\u00e9s","sequence":"first","affiliation":[{"name":"MMDN, University of Montpellier, Ecole Pratique des Hautes Etudes, INSERM, PSL University, Montpellier, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9419-1463","authenticated-orcid":true,"given":"Nicolas","family":"Serratrice","sequence":"additional","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier, University of Montpellier, CNRS, Montpellier, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Gennetier","sequence":"additional","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier, University of Montpellier, CNRS, Montpellier, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina","family":"Devau","sequence":"additional","affiliation":[{"name":"MMDN, University of Montpellier, Ecole Pratique des Hautes Etudes, INSERM, PSL University, Montpellier, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Cobo","sequence":"additional","affiliation":[{"name":"MMDN, University of Montpellier, Ecole Pratique des Hautes Etudes, INSERM, PSL University, Montpellier, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie G.","family":"Trouche","sequence":"additional","affiliation":[{"name":"MMDN, University of Montpellier, Ecole Pratique des Hautes Etudes, INSERM, PSL University, Montpellier, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascaline","family":"Font\u00e8s","sequence":"additional","affiliation":[{"name":"MMDN, University of Montpellier, Ecole Pratique des Hautes Etudes, INSERM, PSL University, Montpellier, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charleine","family":"Zussy","sequence":"additional","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier, University of Montpellier, CNRS, Montpellier, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1226-3516","authenticated-orcid":true,"given":"Philippe","family":"De Deurwaerdere","sequence":"additional","affiliation":[{"name":"Institut des Mat\u00e9riaux Jean Rouxel, CNRS, Bordeaux, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Salinas","sequence":"additional","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier, University of Montpellier, CNRS, Montpellier, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck J.D.","family":"Mennechet","sequence":"additional","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier, University of Montpellier, CNRS, Montpellier, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Dusonchet","sequence":"additional","affiliation":[{"name":"Brain Mind Institute, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, Lausanne, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard L.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Brain Mind Institute, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, Lausanne, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Saggio","sequence":"additional","affiliation":[{"name":"Department of Biology and Biotechnology \u201cC. Darwin,\u201d Sapienza University of Rome, Rome, Italy."},{"name":"Pasteur Institute, Cenci Bolognetti Foundation, Rome, Italy."},{"name":"Institute of Molecular Biology and Pathology, CNR, Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9626-8807","authenticated-orcid":true,"given":"Vasiliki","family":"Kalatzis","sequence":"additional","affiliation":[{"name":"Institute of Neurosciences of Montpellier, INSERM, University of Montpellier, Montpellier, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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