{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T13:17:33Z","timestamp":1779196653466,"version":"3.51.4"},"reference-count":58,"publisher":"American Society for Clinical Investigation","issue":"10","funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","award":["Fellowship Grant from Manpei Suzuki Diabetes Foundation"],"award-info":[{"award-number":["Fellowship Grant from Manpei Suzuki Diabetes Foundation"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","award":["the Japan Ministry of Education,Science,"],"award-info":[{"award-number":["the Japan Ministry of Education,Science,"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","award":["Culture,nos.17K10137"],"award-info":[{"award-number":["Culture,nos.17K10137"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,5,17]]},"abstract":"<jats:p>\n                    A dramatic increase in cardiac fatty acid oxidation occurs following birth. However, cardiac hypertrophy secondary to congenital heart diseases (CHDs) delays this process, thereby decreasing cardiac energetic capacity and function. Cardiac lysine acetylation is involved in modulating fatty acid oxidation. We thus investigated what effect cardiac hypertrophy has on protein acetylation during maturation. Eighty-four right ventricular biopsies were collected from CHD patients and stratified according to age and the absence (\n                    <jats:italic>n<\/jats:italic>\n                    = 44) or presence of hypertrophy (\n                    <jats:italic>n<\/jats:italic>\n                    = 40). A maturational increase in protein acetylation was evident in nonhypertrophied hearts but not in hypertrophied hearts. The fatty acid \u03b2-oxidation enzymes, long-chain acyl CoA dehydrogenase (LCAD) and \u03b2-hydroxyacyl CoA dehydrogenase (\u03b2HAD), were hyperacetylated and their activities positively correlated with their acetylation after birth in nonhypertrophied hearts but not hypertrophied hearts. In line with this, decreased cardiac fatty acid oxidation and reduced acetylation of LCAD and \u03b2HAD occurred in newborn rabbits subjected to cardiac hypertrophy due to an aortocaval shunt. Silencing the mRNA of general control of amino acid synthesis 5-like protein 1 reduced acetylation of LCAD and \u03b2HAD as well as fatty acid oxidation rates in cardiomyocytes. Thus, hypertrophy in CHDs prevents the postnatal increase in myocardial acetylation, resulting in a delayed maturation of cardiac fatty acid oxidation.\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.99239","type":"journal-article","created":{"date-parts":[[2018,5,16]],"date-time":"2018-05-16T11:00:54Z","timestamp":1526468454000},"source":"Crossref","is-referenced-by-count":36,"title":["Acetylation contributes to hypertrophy-caused maturational delay of cardiac energy metabolism"],"prefix":"10.1172","volume":"3","author":[{"given":"Arata","family":"Fukushima","sequence":"first","affiliation":[{"name":"Cardiovascular Translational Science Institute, University of Alberta, Edmonton, Alberta, Canada."},{"name":"Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Cardiovascular Translational Science Institute, University of Alberta, Edmonton, Alberta, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alda","family":"Huqi","sequence":"additional","affiliation":[{"name":"Cardiovascular Translational Science Institute, University of Alberta, Edmonton, Alberta, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria H.","family":"Lam","sequence":"additional","affiliation":[{"name":"Cardiovascular Translational Science Institute, University of Alberta, Edmonton, Alberta, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Rawat","sequence":"additional","affiliation":[{"name":"Cardiovascular Translational Science Institute, University of Alberta, Edmonton, Alberta, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tariq","family":"Altamimi","sequence":"additional","affiliation":[{"name":"Cardiovascular Translational Science Institute, University of Alberta, Edmonton, Alberta, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cory S.","family":"Wagg","sequence":"additional","affiliation":[{"name":"Cardiovascular Translational Science Institute, University of Alberta, Edmonton, Alberta, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khushmol K.","family":"Dhaliwal","sequence":"additional","affiliation":[{"name":"Cardiovascular Translational Science Institute, University of Alberta, Edmonton, Alberta, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa K.","family":"Hornberger","sequence":"additional","affiliation":[{"name":"Cardiovascular Translational Science Institute, University of Alberta, Edmonton, Alberta, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul F.","family":"Kantor","sequence":"additional","affiliation":[{"name":"Cardiovascular Translational Science Institute, University of Alberta, Edmonton, Alberta, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan M.","family":"Rebeyka","sequence":"additional","affiliation":[{"name":"Cardiovascular Translational Science Institute, University of Alberta, Edmonton, Alberta, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary D.","family":"Lopaschuk","sequence":"additional","affiliation":[{"name":"Cardiovascular Translational Science Institute, University of Alberta, Edmonton, Alberta, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"232","published-online":{"date-parts":[[2018,5,17]]},"reference":[{"issue":"2","key":"B1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1161\/CIRCULATIONAHA.106.627224","article-title":"Congenital heart disease in the general population: changing prevalence and age distribution","volume":"115","author":"Marelli","year":"2007","journal-title":"Circulation"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.03.085"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.10.065"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq032"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2015-308348"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.012975"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00063-7"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00804.2011"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.306585"},{"issue":"6 Pt 2","key":"B10","first-page":"H1698","article-title":"Glycolysis is predominant source of myocardial ATP production immediately after birth","volume":"261","author":"Lopaschuk","year":"1991","journal-title":"Am J Physiol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1992.72.2.507"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/26.12.1172"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1172\/JCI10268"},{"issue":"6 Pt 2","key":"B14","first-page":"H2122","article-title":"Characterization of cardiac malonyl-CoA decarboxylase and its putative role in regulating fatty acid oxidation","volume":"275","author":"Dyck","year":"1998","journal-title":"Am J Physiol"},{"issue":"41","key":"B15","doi-asserted-by":"crossref","first-page":"25871","DOI":"10.1016\/S0021-9258(18)47327-9","article-title":"Acetyl-CoA carboxylase involvement in the rapid maturation of fatty acid oxidation in the newborn rabbit heart","volume":"269","author":"Lopaschuk","year":"1994","journal-title":"J Biol Chem"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00900.2015"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvu156"},{"issue":"12","key":"B18","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1016\/j.bbadis.2016.07.020","article-title":"Acetylation control of cardiac fatty acid \u03b2-oxidation and energy metabolism in obesity, diabetes, and heart failure","volume":"1862","author":"Fukushima","year":"2016","journal-title":"Biochim Biophys Acta"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/nature08778"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1126\/science.1179689"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1302961110"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.2337\/db14-1050"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20120118"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000117088.36577.EB"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2010.206"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e3181e74a14"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.111.966127"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M802418200"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-012-0982-0"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M608657200"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2012.02.027"},{"issue":"2","key":"B32","first-page":"837","article-title":"Developmental regulation of GLUT-1 (erythroid\/Hep G2) and GLUT-4 (muscle\/fat) glucose transporter expression in rat heart, skeletal muscle, and brown adipose tissue","volume":"130","author":"Santaluc\u00eda","year":"1992","journal-title":"Endocrinology"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.112.966705"},{"issue":"1","key":"B34","article-title":"Mitochondrial protein hyperacetylation in the failing heart","volume":"2","author":"Horton","year":"2016","journal-title":"JCI Insight"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.022495"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1172\/JCI14080"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.01.002"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0178354"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.521641"},{"issue":"4","key":"B40","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.bbalip.2014.02.001","article-title":"Regulation of autophagy and mitophagy by nutrient availability and acetylation","volume":"1841","author":"Webster","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.2337\/db14-0388"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.09.030"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00015.2009"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00636.2012"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2009.09.017"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200208000-00021"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004042"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.109.888479"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)80601-5"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e318184d281"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1136\/heart.83.6.667"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2605"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.euje.2005.12.014"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.112.000228"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.45.29540"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.2004.04218.x"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0129303"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120257"}],"container-title":["JCI Insight"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/insight.jci.org\/articles\/view\/99239\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T13:00:22Z","timestamp":1779195622000},"score":1,"resource":{"primary":{"URL":"https:\/\/insight.jci.org\/articles\/view\/99239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,17]]},"references-count":58,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2018,5,17]]},"published-print":{"date-parts":[[2018,5,17]]}},"alternative-id":["10.1172\/jci.insight.99239"],"URL":"https:\/\/doi.org\/10.1172\/jci.insight.99239","relation":{},"ISSN":["2379-3708"],"issn-type":[{"value":"2379-3708","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,17]]},"article-number":"e99239"}}