{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:59:43Z","timestamp":1791874783529,"version":"4.3.4"},"reference-count":58,"publisher":"American Society for Clinical Investigation","issue":"8","funder":[{"name":"National Institutes of Health Intramural Research Program","award":["1ZIABC0114,79-04"],"award-info":[{"award-number":["1ZIABC0114,79-04"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,4,19]]},"abstract":"<jats:p>\n                    T cell receptor (TCR) T cell therapy is a promising cancer treatment modality. However, its successful development for epithelial cancers may depend on the identification of high-avidity TCRs directed against tumor-restricted target antigens. The human papillomavirus (HPV) E7 antigen is an attractive therapeutic target that is constitutively expressed by HPV\n                    <jats:sup>+<\/jats:sup>\n                    cancers but not by healthy tissues. It is unknown if genetically engineered TCR T cells that target E7 can mediate regression of HPV\n                    <jats:sup>+<\/jats:sup>\n                    cancers. We identified an HPV-16 E7-specific, HLA-A*02:01-restricted TCR from a uterine cervix biopsy from a woman with cervical intraepithelial neoplasia. This TCR demonstrated high functional avidity, with CD8 coreceptor\u2013independent tumor targeting. Human T cells transduced to express the TCR specifically recognized and killed HPV-16\n                    <jats:sup>+<\/jats:sup>\n                    cervical and oropharyngeal cancer cell lines and mediated regression of established HPV-16\n                    <jats:sup>+<\/jats:sup>\n                    human cervical cancer tumors in a mouse model. These findings support the therapeutic potential of this approach and established the basis for an E7 TCR gene therapy clinical trial in patients with metastatic HPV\n                    <jats:sup>+<\/jats:sup>\n                    cancers (NCT02858310).\n                  <\/jats:p>","DOI":"10.1172\/jci.insight.99488","type":"journal-article","created":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T11:02:49Z","timestamp":1524049369000},"source":"Crossref","is-referenced-by-count":162,"title":["Engineered T cells targeting E7 mediate regression of human papillomavirus cancers in a murine model"],"prefix":"10.1172","volume":"3","author":[{"given":"Benjamin Y.","family":"Jin","sequence":"first","affiliation":[{"name":"Experimental Transplantation and Immunology Branch, National Cancer Institute, NIH, Bethesda, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy E.","family":"Campbell","sequence":"additional","affiliation":[{"name":"Experimental 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