{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T22:46:14Z","timestamp":1790549174592,"version":"4.1.0"},"reference-count":94,"publisher":"American Society for Clinical Investigation","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,5,1]]},"DOI":"10.1172\/jci120330","type":"journal-article","created":{"date-parts":[[2018,4,30]],"date-time":"2018-04-30T18:01:29Z","timestamp":1525111289000},"page":"1711-1719","source":"Crossref","is-referenced-by-count":83,"title":["Interpreting heterogeneity in intestinal tuft cell structure and function"],"prefix":"10.1172","volume":"128","author":[{"given":"Amrita","family":"Banerjee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliot T.","family":"McKinley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2894-3353","authenticated-orcid":false,"given":"Jakob","family":"von Moltke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2180-3844","authenticated-orcid":false,"given":"Robert J.","family":"Coffey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken S.","family":"Lau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2018,5,1]]},"reference":[{"issue":"1","key":"B1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/BF00238045","article-title":"A new morphological aspect of the brush cells of the mouse gallbladder epithelium","volume":"201","author":"Luciano","year":"1979","journal-title":"Cell Tissue Res"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00309889"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0029(19970915)38:6<598::AID-JEMT4>3.0.CO;2-B"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1177\/002215540305100207"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001840407"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1177\/42.10.7523487"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/BF00297540"},{"issue":"pt 3","key":"B8","first-page":"541","article-title":"Undifferentiated cells in gastric mucosa","volume":"102","author":"Johnson","year":"1968","journal-title":"J Anat"},{"issue":"1","key":"B9","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0022-5320(68)80032-2","article-title":"The alveolar brush cell in rat lung \u2014 a third pneumonocyte","volume":"23","author":"Meyrick","year":"1968","journal-title":"J Ultrastruct Res"},{"issue":"2","key":"B10","first-page":"149","article-title":"[Type III pneumocyte. The alveolar brush-border cell in rat lung. Study by transmission electron microscopy (author\u2019s transl)]","volume":"36","author":"Foliguet","year":"1980","journal-title":"Poumon Coeur"},{"issue":"4","key":"B11","first-page":"321","article-title":"Ultrastructural study of the alveolar brush cell","volume":"26","author":"Hijiya","year":"1977","journal-title":"J Electron Microsc (Tokyo)"},{"issue":"3","key":"B12","first-page":"223","article-title":"Electron microscope study of the alveolar brush cell","volume":"27","author":"Hijiya","year":"1978","journal-title":"J Electron Microsc (Tokyo)"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950040312"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092190112"},{"issue":"suppl","key":"B15","first-page":"115","article-title":"Electron microscope observations on a special cell type in the gastro-intestinal epithelium of some laboratory animals","volume":"154","author":"Isomaki","year":"1962","journal-title":"Acta Pathol Microbiol Scand A"},{"issue":"suppl","key":"B16","first-page":"1","article-title":"A new cell type (tuft cell) in the gastrointestinal mucosa of the rat","volume":"240","author":"Isom\u00e4ki","year":"1973","journal-title":"Acta Pathol Microbiol Scand A"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(76)80099-8"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.22.3.701"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1007\/s00795-008-0412-0"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2016.04.016"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-073X.2007.00188.x"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-012-0984-7"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2016.68"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00073.2017"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1007\/BF00271037"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201010127"},{"issue":"5","key":"B27","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s004180000148","article-title":"The apical membrane of intestinal brush cells possesses a specialised, but species-specific, composition of glycoconjugates \u2014 on-section and in vivo lectin labelling in rats, guinea-pigs and mice","volume":"113","author":"Gebert","year":"2000","journal-title":"Histochem Cell Biol"},{"issue":"5","key":"B28","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S0022-5320(66)80015-1","article-title":"The fine structure of multivesicular cells with large microvilli in the epithelium of the mouse colon","volume":"16","author":"Silva","year":"1966","journal-title":"J Ultrastruct Res"},{"issue":"11","key":"B29","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.93487","article-title":"Optimized multiplex immunofluorescence single-cell analysis reveals tuft cell heterogeneity","volume":"2","author":"McKinley","year":"2017","journal-title":"JCI Insight"},{"issue":"6","key":"B30","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1053\/j.gastro.2009.06.072","article-title":"DCAMKL-1 expression identifies Tuft cells rather than stem cells in the adult mouse intestinal epithelium","volume":"137","author":"Gerbe","year":"2009","journal-title":"Gastroenterology"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007-0621"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1002\/stem.193"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.90446.2008"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001400203"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2007.00738.x"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-01520-x"},{"issue":"suppl","key":"B37","first-page":"115","article-title":"Electron microscope observations on a special cell type in the gastro-intestinal epithelium of some laboratory animals","volume":"154","author":"Isom\u00e4ki","year":"1962","journal-title":"Acta Pathol Microbiol Scand A"},{"key":"B38","first-page":"1","article-title":"A new cell type (tuft cell) in the gastrointestinal mucosa of the rat. A transmission and scanning electron microscopic study","volume":"suppl 240","author":"Isom\u00e4ki","year":"1973","journal-title":"Acta Pathol Microbiol Scand A"},{"issue":"4","key":"B39","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1076\/ejom.40.4.235.16690","article-title":"Three-dimensional structure of apical vesicles of tuft cells in the main excretory duct of the rat submandibular gland","volume":"40","author":"Sato","year":"2002","journal-title":"Eur J Morphol"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0185(199707)248:3<325::AID-AR4>3.0.CO;2-O"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1159\/000144796"},{"issue":"4","key":"B42","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1076\/0924-3860(200010)38:4;1-O;FT227","article-title":"Tuft cells in the main excretory duct of the rat submandibular gland","volume":"38","author":"Sato","year":"2000","journal-title":"Eur J Morphol"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0089881"},{"key":"B44","article-title":"Chemical coding and chemosensory properties of cholinergic brush cells in the mouse gastrointestinal and biliary tract","volume":"6","author":"Sch\u00fctz","year":"2015","journal-title":"Front Physiol"},{"key":"B45","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2202-8-49","article-title":"TRPM5, a taste-signaling transient receptor potential ion-channel, is a ubiquitous signaling component in chemosensory cells","volume":"8","author":"Kaske","year":"2007","journal-title":"BMC Neurosci"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2005.03.001"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1007\/BF01463662"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/bjl034"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21768"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001560403"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2017.06.014"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.05.034"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2011.12.009"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2006.07.040"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1201652109"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.03.047"},{"issue":"3","key":"B57","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1053\/j.gastro.2010.05.081","article-title":"Atonal homolog 1 is required for growth and differentiation effects of notch\/gamma-secretase inhibitors on normal and cancerous intestinal epithelial cells","volume":"139","author":"Kazanjian","year":"2010","journal-title":"Gastroenterology"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0126085"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1242\/dev.070763"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1172\/JCI73434"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2017.10.012"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2820"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0189340"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1038\/nature16527"},{"issue":"9","key":"B65","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.bbalip.2006.07.005","article-title":"Arachidonic acid can function as a signaling modulator by activating the TRPM5 cation channel in taste receptor cells","volume":"1761","author":"Oike","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00066.2008"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf1648"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.13.6631"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1007\/s004180050292"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0706890104"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.05.020"},{"issue":"1","key":"B72","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/ncb2384","article-title":"Single-molecule transcript counting of stem-cell markers in the mouse intestine","volume":"14","author":"Itzkovitz","year":"2011","journal-title":"Nat Cell Biol"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1038\/nature16161"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1038\/nature24489"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2014.06.003"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf3229"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1566"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1118857109"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1097\/HP.0b013e318266ee13"},{"issue":"pt 11","key":"B80","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1242\/jcs.115.11.2381","article-title":"Intestinal stem cells protect their genome by selective segregation of template DNA strands","volume":"115","author":"Potten","year":"2002","journal-title":"J Cell Sci"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.10.040"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1038\/nn1704"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1677\/ERC-09-0301"},{"issue":"31","key":"B84","doi-asserted-by":"crossref","first-page":"30876","DOI":"10.18632\/oncotarget.5129","article-title":"Dclk1+ small intestinal epithelial tuft cells display the hallmarks of quiescence and self-renewal","volume":"6","author":"Chandrakesan","year":"2015","journal-title":"Oncotarget"},{"issue":"10","key":"B85","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1038\/ncb3025","article-title":"Mammary stem cells have myoepithelial cell properties","volume":"16","author":"Prater","year":"2014","journal-title":"Nat Cell Biol"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1038\/nature10573"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2481"},{"key":"B88","doi-asserted-by":"crossref","DOI":"10.1038\/srep37667","article-title":"Intestinal tuft cells regulate the ATM mediated DNA Damage response via Dclk1 dependent mechanism for crypt restitution following radiation injury","volume":"6","author":"Chandrakesan","year":"2016","journal-title":"Sci Rep"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201694660"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119296"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.03.017"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-06070-w"},{"key":"B93","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.588","article-title":"TSC2\/mTORC1 signaling controls Paneth and goblet cell differentiation in the intestinal epithelium","volume":"6","author":"Zhou","year":"2015","journal-title":"Cell Death Dis"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1038\/nature03659"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/120330\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T13:24:29Z","timestamp":1691069069000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/120330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,1]]},"references-count":94,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2018,5,1]]},"published-print":{"date-parts":[[2018,5,1]]}},"alternative-id":["10.1172\/JCI120330"],"URL":"https:\/\/doi.org\/10.1172\/jci120330","relation":{},"ISSN":["0021-9738","1558-8238"],"issn-type":[{"value":"0021-9738","type":"print"},{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,1]]}}}