{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T21:17:00Z","timestamp":1788297420361,"version":"build-2803163510"},"reference-count":54,"publisher":"American Society for Clinical Investigation","funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"crossref","award":["PG\/15\/44\/315,4"],"award-info":[{"award-number":["PG\/15\/44\/315,4"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000361","name":"Diabetes UK","doi-asserted-by":"crossref","award":["12\/0004458"],"award-info":[{"award-number":["12\/0004458"]}],"id":[{"id":"10.13039\/501100000361","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Medical Research Council","award":["MR\/K003291\/1"],"award-info":[{"award-number":["MR\/K003291\/1"]}]},{"name":"Diabetes Research & Wellness Foundation","award":["DRWF PP\/201"],"award-info":[{"award-number":["DRWF PP\/201"]}]},{"DOI":"10.13039\/501100010767","name":"Innovative Medicines Initiative","doi-asserted-by":"crossref","award":["IMI-2008\/115006"],"award-info":[{"award-number":["IMI-2008\/115006"]}],"id":[{"id":"10.13039\/501100010767","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Mark Kearney University of Leeds","award":["RG\/15\/7\/31521"],"award-info":[{"award-number":["RG\/15\/7\/31521"]}]},{"name":"Wellcome Trust","award":["072960\/Z\/03\/Z"],"award-info":[{"award-number":["072960\/Z\/03\/Z"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,29]]},"DOI":"10.1172\/jci122237","type":"journal-article","created":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T16:29:07Z","timestamp":1589473747000},"source":"Crossref","is-referenced-by-count":22,"title":["Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction"],"prefix":"10.1172","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8553-3863","authenticated-orcid":false,"given":"Paul J.","family":"Meakin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bethany M.","family":"Coull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zofia","family":"Tuharska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"McCaffery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4674-0210","authenticated-orcid":false,"given":"Ioannis","family":"Akoumianakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6983-5423","authenticated-orcid":false,"given":"Charalambos","family":"Antoniades","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn J.","family":"Griffin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Platt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3312-0925","authenticated-orcid":false,"given":"Claire H.","family":"Ozber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6213-6358","authenticated-orcid":false,"given":"Nadira Y.","family":"Yuldasheva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natallia","family":"Makava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Skromna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Prescott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4869-178X","authenticated-orcid":false,"given":"Alison D.","family":"McNeilly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moneeza","family":"Siddiqui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin N.A.","family":"Palmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9889-0229","authenticated-orcid":false,"given":"Faisel","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L.J.","family":"Ashford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2020,6,29]]},"reference":[{"key":"B1","doi-asserted-by":"crossref","DOI":"10.1186\/s12916-014-0130-5","article-title":"Cardiovascular risk factors and future risk of Alzheimer\u2019s disease","volume":"12","author":"de Bruijn","year":"2014","journal-title":"BMC Med"},{"key":"B2","doi-asserted-by":"crossref","DOI":"10.1186\/s12916-014-0206-2","article-title":"The overlap between vascular disease and Alzheimer\u2019s disease--lessons from pathology","volume":"12","author":"Attems","year":"2014","journal-title":"BMC Med"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2013.159"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000403"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-004-0822-6"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1387"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/nm0905-923"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-1069"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jash.2010.02.004"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199807233390404"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.835223"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2006.01223.x"},{"issue":"23 suppl 1","key":"B13","first-page":"III27","article-title":"Role of endothelial dysfunction in atherosclerosis","volume":"109","author":"Davignon","year":"2004","journal-title":"Circulation"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00994-X"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/380168a0"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.2174\/187152906776092695"},{"issue":"1","key":"B17","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.atherosclerosis.2009.10.040","article-title":"Increased atherosclerosis and vascular inflammation in APP transgenic mice with apolipoprotein E deficiency","volume":"210","author":"Tibolla","year":"2017","journal-title":"Atherosclerosis"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.01.032"},{"key":"B19","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-015-0304-x","article-title":"Amyloid \u03b2 peptide-induced inhibition of endothelial nitric oxide production involves oxidative stress-mediated constitutive eNOS\/HSP90 interaction and disruption of agonist-mediated Akt activation","volume":"12","author":"Lamoke","year":"2015","journal-title":"J Neuroinflammation"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M407358200"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2008.10.004"},{"key":"B22","doi-asserted-by":"crossref","DOI":"10.1038\/srep26801","article-title":"Plasma \u03b2-amyloid in Alzheimer\u2019s disease and vascular disease","volume":"6","author":"Janelidze","year":"2016","journal-title":"Sci Rep"},{"issue":"1","key":"B23","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3233\/JAD-2012-121351","article-title":"Supplementation of nitric oxide attenuates A\u03b2PP and BACE1 protein in cerebral microcirculation of eNOS-deficient mice","volume":"33","author":"Austin","year":"2013","journal-title":"J Alzheimers Dis"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1172\/JCI79742"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1006\/nbdi.2000.0304"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20110512"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-016-3960-1"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.03.016"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/6.9.1535"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-18388-6"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.24.13287"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2003.02444.x"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.2337\/db09-1772"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(00)00043-6"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2006.10.011"},{"key":"B36","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/9780470942390.mo100149","article-title":"Arterial pressure monitoring in mice","volume":"1","author":"Zhao","year":"2011","journal-title":"Curr Protoc Mouse Biol"},{"issue":"3","key":"B37","first-page":"e21","article-title":"Effects of isoflurane anesthesia on the cardiovascular function of the C57BL\/6 mouse","volume":"52","author":"Constantinides","year":"2011","journal-title":"ILAR J"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2009.09.004"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(02)00135-5"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e08-07-0777"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2014.04.007"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.49.7.1239"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084170"},{"issue":"1\u20133","key":"B44","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0165-1838(00)00126-0","article-title":"Say NO to ET","volume":"81","author":"Vanhoutte","year":"2000","journal-title":"J Auton Nerv Syst"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1006\/nbdi.2002.0492"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015686"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(03)00007-1"},{"issue":"4","key":"B48","first-page":"461","article-title":"Secretion of Alzheimer\u2019s disease Abeta amyloid peptide by activated human platelets","volume":"78","author":"Li","year":"1998","journal-title":"Lab Invest"},{"issue":"9\u201310","key":"B49","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1002\/prca.201200135","article-title":"Soluble amyloid precursor protein 770 is a novel biomarker candidate for acute coronary syndrome","volume":"7","author":"Kitazume","year":"2013","journal-title":"Proteomics Clin Appl"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2007.01.009"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyx140"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12359"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2012.10.008"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1021\/jm049379g"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/122237\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T02:58:47Z","timestamp":1696129127000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/122237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,29]]},"references-count":54,"alternative-id":["10.1172\/JCI122237"],"URL":"https:\/\/doi.org\/10.1172\/jci122237","relation":{},"ISSN":["0021-9738","1558-8238"],"issn-type":[{"value":"0021-9738","type":"print"},{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,29]]},"article-number":"10.1172\/JCI122237"}}