{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T22:23:45Z","timestamp":1772749425054,"version":"3.50.1"},"reference-count":77,"publisher":"American Society for Clinical Investigation","issue":"3","funder":[{"name":"National Institutes of Health (NIH) \/ Eunice Kennedy Shriver National Institute of Child Health & Human Development","award":["R03HD064749"],"award-info":[{"award-number":["R03HD064749"]}]},{"name":"Saint Louis University Department of Pediatrics in association with the Fleur de Lis Organization and the Cardinal Glennon Foundation","award":["AMM"],"award-info":[{"award-number":["AMM"]}]},{"name":"Pontificia Universidad Javeriana Grant","award":["PS3887"],"award-info":[{"award-number":["PS3887"]}]},{"name":"Convocatoria Doctorados Nacionales - Departamento Administrativo para la Ciencia y la Educacion \u2013 COLCIENCIAS","award":["ACS"],"award-info":[{"award-number":["ACS"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,27]]},"DOI":"10.1172\/jci125607","type":"journal-article","created":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T17:01:25Z","timestamp":1574182885000},"page":"1288-1300","source":"Crossref","is-referenced-by-count":7,"title":["Oral immunotherapy tolerizes mice to enzyme replacement therapy for Morquio A syndrome"],"prefix":"10.1172","volume":"130","author":[{"given":"Angela C.","family":"Sosa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Kariuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Gan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan P.","family":"Knutsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clifford J.","family":"Bellone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel A.","family":"Guzm\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis A.","family":"Barrera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunji","family":"Tomatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anil K.","family":"Chauhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Armbrecht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana M.","family":"Monta\u00f1o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"232","published-online":{"date-parts":[[2020,1,27]]},"reference":[{"key":"B1"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.9.1283"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-007-0529-7"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.2174\/138920111795542615"},{"issue":"11","key":"B5","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1002\/humu.22635","article-title":"Morquio A syndrome-associated mutations: a review of alterations in the GALNS gene and a new locus-specific database","volume":"35","author":"Morrone","year":"2014","journal-title":"Hum Mutat"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2003.018010"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2016.11.002"},{"issue":"11","key":"B8","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1002\/ajmg.a.36735","article-title":"GALNS mutations in Indian patients with mucopolysaccharidosis IVA","volume":"164A","author":"Bidchol","year":"2014","journal-title":"Am J Med Genet A"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-013-9587-1"},{"key":"B10","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.2147\/DDDT.S68562","article-title":"Impact of enzyme replacement therapy and hematopoietic stem cell transplantation in patients with Morquio A syndrome","volume":"9","author":"Tomatsu","year":"2015","journal-title":"Drug Des Devel Ther"},{"key":"B11"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-014-0210-z"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-009-0062-x"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.02.047"},{"key":"B15","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.1007\/s10545-009-1057-4","article-title":"Postmortem studies on a patient with mucopolysaccharidosis type I: histopathological findings after one year of enzyme replacement therapy","volume":"32 Suppl 1","author":"Yano","year":"2009","journal-title":"J Inherit Metab Dis"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-2047"},{"key":"B17","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1080\/21678707.2017.1366900","article-title":"Enzyme replacement therapy for mucopolysaccharidosis IVA (Morquio A syndrome): Milestones and challenges","volume":"5","author":"Puckett","year":"2017","journal-title":"Expert Opin Orphan Drugs"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1172\/JCI36521"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2003.08.004"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1484"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-008-0309-3"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.38014"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2015.169"},{"issue":"10","key":"B24","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1002\/ajmg.a.37172","article-title":"Safety and physiological effects of two different doses of elosulfase alfa in patients with morquio a syndrome: A randomized, double-blind, pilot study","volume":"167A","author":"Burton","year":"2015","journal-title":"Am J Med Genet A"},{"issue":"1\u20132","key":"B25","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.ymgme.2016.05.018","article-title":"Long-term endurance and safety of elosulfase alfa enzyme replacement therapy in patients with Morquio A syndrome","volume":"119","author":"Hendriksz","year":"2016","journal-title":"Mol Genet Metab"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-014-9715-6"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2003-0988-L"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31319"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2009.08.003"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2012.01.019"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2011.4"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2015.11.001"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1002\/msj.21302"},{"issue":"1\u20132","key":"B34","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0165-2478(91)90206-P","article-title":"A critical review of immunosuppressive therapy","volume":"29","author":"Briggs","year":"1991","journal-title":"Immunol Lett"},{"issue":"5","key":"B35","first-page":"521","article-title":"Neurological complications in kidney transplant recipients","volume":"18","author":"Ponticelli","year":"2005","journal-title":"J Nephrol"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/nri2869"},{"issue":"Web Server issue","key":"B37","doi-asserted-by":"crossref","first-page":"W513","DOI":"10.1093\/nar\/gkn254","article-title":"Immune epitope database analysis resource (IEDB-AR)","volume":"36","author":"Zhang","year":"2008","journal-title":"Nucleic Acids Res"},{"issue":"6","key":"B38","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s00251-004-0709-7","article-title":"Enhancement to the RANKPEP resource for the prediction of peptide binding to MHC molecules using profiles","volume":"56","author":"Reche","year":"2004","journal-title":"Immunogenetics"},{"issue":"1\u20132","key":"B39","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ymgme.2006.05.012","article-title":"Determinant factors of spectrum of missense variants in mucopolysaccharidosis IVA gene","volume":"89","author":"Tomatsu","year":"2006","journal-title":"Mol Genet Metab"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2012.08.020"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2009.03.010"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-03-0727"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20052016"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2005.00280.x"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2012.10.013"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1006\/mgme.1999.2894"},{"key":"B47","doi-asserted-by":"crossref","DOI":"10.1038\/mtm.2015.53","article-title":"Targeted approaches to induce immune tolerance for Pompe disease therapy","volume":"3","author":"Doerfler","year":"2016","journal-title":"Mol Ther Methods Clin Dev"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.07.029"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2011.0065"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12209"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-010-9209-0"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e3182174703"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.21.120601.141110"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.2174\/138920007780362536"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1172\/JCI28801"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050419"},{"issue":"4","key":"B57","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1111\/j.1365-2222.2009.03442.x","article-title":"Multiple T cell epitope peptides suppress allergic responses in an egg allergy mouse model by the elicitation of forkhead box transcription factor 3- and transforming growth factor-beta-associated mechanisms","volume":"40","author":"Yang","year":"2010","journal-title":"Clin Exp Allergy"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2007.10.008"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2007.06538.x"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0909235107"},{"key":"B61","first-page":"156","article-title":"The transcriptional regulator NFIL3 controls IgE production","volume":"121","author":"Rothman","year":"2010","journal-title":"Trans Am Clin Climatol Assoc"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003484"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1038\/ni1180"},{"issue":"4","key":"B64","doi-asserted-by":"crossref","first-page":"645","DOI":"10.2217\/imt.09.21","article-title":"Targeting the immunoregulatory indoleamine 2,3 dioxygenase pathway in immunotherapy","volume":"1","author":"Johnson","year":"2009","journal-title":"Immunotherapy"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1038\/nri1457"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.3109\/08830180903349669"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200204)32:4<1109::AID-IMMU1109>3.0.CO;2-K"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2012.4"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2017.9.2.107"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.1.146"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2007.01.004"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(90)90339-T"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg366"},{"issue":"6","key":"B74","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1093\/hmg\/ddm353","article-title":"Enzyme replacement therapy in a murine model of Morquio A syndrome","volume":"17","author":"Tomatsu","year":"2008","journal-title":"Hum Mol Genet"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02242-09"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi364"},{"issue":"1","key":"B77","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J R Stat Soc Series B Stat Methodol"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/125607\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T10:14:00Z","timestamp":1722075240000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/125607"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,27]]},"references-count":77,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,3,2]]},"published-print":{"date-parts":[[2020,3,2]]}},"alternative-id":["10.1172\/JCI125607"],"URL":"https:\/\/doi.org\/10.1172\/jci125607","relation":{},"ISSN":["0021-9738","1558-8238"],"issn-type":[{"value":"0021-9738","type":"print"},{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,27]]}}}