{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T19:10:45Z","timestamp":1778699445555,"version":"3.51.4"},"reference-count":86,"publisher":"American Society for Clinical Investigation","issue":"4","funder":[{"DOI":"10.13039\/501100004089","name":"Krembil Foundation","doi-asserted-by":"crossref","award":["N\/a"],"award-info":[{"award-number":["N\/a"]}],"id":[{"id":"10.13039\/501100004089","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Foundation Fighting Blindness","award":["Operating"],"award-info":[{"award-number":["Operating"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["EY027750"],"award-info":[{"award-number":["EY027750"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"crossref","award":["p30EY025585"],"award-info":[{"award-number":["p30EY025585"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100009408","name":"Fondation Brain Canada","doi-asserted-by":"crossref","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/100009408","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,16]]},"DOI":"10.1172\/jci125898","type":"journal-article","created":{"date-parts":[[2020,3,15]],"date-time":"2020-03-15T22:01:07Z","timestamp":1584309667000},"page":"2054-2068","source":"Crossref","is-referenced-by-count":15,"title":["Neogenin neutralization prevents photoreceptor loss in inherited retinal degeneration"],"prefix":"10.1172","volume":"130","author":[{"given":"Jason","family":"Charish","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza P.","family":"Shabanzadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Mehlen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6199-1221","authenticated-orcid":false,"given":"Santhosh","family":"Sethuramanujam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidekiyo","family":"Harada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera L.","family":"Bonilha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gautam","family":"Awatramani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9184-7212","authenticated-orcid":false,"given":"Rod","family":"Bremner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6221-4130","authenticated-orcid":false,"given":"Philippe P.","family":"Monnier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"232","published-online":{"date-parts":[[2020,3,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2717"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.visres.2012.09.012"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12203"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-8410"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.017913"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.201210811"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.09.030186.000511"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-008-8045-9"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523800002753"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.24.12093"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-06-02063.2002"},{"issue":"5 pt 2","key":"B12","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.1523\/JNEUROSCI.14-05-03083.1994","article-title":"Photomechanical movements of cultured embryonic photoreceptors: regulation by exogenous neuromodulators and by a regulable source of endogenous dopamine","volume":"14","author":"Stenkamp","year":"1994","journal-title":"J Neurosci"},{"key":"B13","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2013.12","article-title":"Retinitis pigmentosa: rapid neurodegeneration is governed by slow cell death mechanisms","volume":"4","author":"Sahaboglu","year":"2013","journal-title":"Cell Death Dis"},{"issue":"5","key":"B14","first-page":"1655","article-title":"Retinal cAMP levels during the progression of retinal degeneration in rhodopsin P23H and S334ter transgenic rats","volume":"43","author":"Traverso","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1995.2686"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1977.tb03940.x"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032472"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2008.05822.x"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4934-03.2004"},{"issue":"10","key":"B20","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1001\/archneur.62.10.1561","article-title":"Central nervous system injury-induced repulsive guidance molecule expression in the adult human brain","volume":"62","author":"Schwab","year":"2005","journal-title":"Arch Neurol"},{"issue":"157","key":"B21","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2001521","article-title":"Dependence receptors: from basic research to drug development","volume":"4","author":"Mehlen","year":"2011","journal-title":"Sci Signal"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.06.014"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.9.4016"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0112142"},{"key":"B25","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2015.109","article-title":"Uncoupling Neogenin association with lipid rafts promotes neuronal survival and functional recovery after stroke","volume":"6","author":"Shabanzadeh","year":"2015","journal-title":"Cell Death Dis"},{"key":"B26","first-page":"2579","article-title":"Review: the history and role of naturally occurring mouse models with Pde6b mutations","volume":"19","author":"Han","year":"2013","journal-title":"Mol Vis"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.19.8322"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.3.974"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057163"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.209759"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.06.042"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21144"},{"key":"B33","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2013.12","article-title":"Retinitis pigmentosa: rapid neurodegeneration is governed by slow cell death mechanisms","volume":"4","author":"Sahaboglu","year":"2013","journal-title":"Cell Death Dis"},{"key":"B34","doi-asserted-by":"crossref","DOI":"10.1186\/1750-1172-1-40","article-title":"Retinitis pigmentosa","volume":"1","author":"Hamel","year":"2006","journal-title":"Orphanet J Rare Dis"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-011-1791-9"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.04.079"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2235688100"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1157"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1076\/ceyr.16.7.663.5061"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1177\/0897190016647232"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.12.004"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.16-19415"},{"key":"B43","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.30577","article-title":"Small molecule Photoregulin3 prevents retinal degeneration in the RhoP23H mouse model of retinitis pigmentosa","volume":"6","author":"Nakamura","year":"2017","journal-title":"Elife"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-74904-4_4"},{"issue":"3","key":"B45","first-page":"592","article-title":"Protection of mouse photoreceptors by survival factors in retinal degenerations","volume":"39","author":"LaVail","year":"1998","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3301929"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1006\/mthe.2001.0473"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1303604110"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00144.2007"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00704.2010"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.02.014"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.02.035"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.visres.2006.11.020"},{"key":"B54","doi-asserted-by":"crossref","DOI":"10.1038\/srep07601","article-title":"Retinal structure and function preservation by polysaccharides of wolfberry in a mouse model of retinal degeneration","volume":"4","author":"Wang","year":"2014","journal-title":"Sci Rep"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523805225166"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04-0541"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4835(84)90163-5"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1006\/exer.2001.1037"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1172\/JCI69076"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-19-05986.1996"},{"key":"B61"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-008-8045-9"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.2011.02273.x"},{"issue":"32","key":"B64","doi-asserted-by":"crossref","first-page":"24138","DOI":"10.1016\/S0021-9258(20)80502-X","article-title":"Cyclic AMP selectively increases renin mRNA stability in cultured juxtaglomerular granular cells","volume":"268","author":"Chen","year":"1993","journal-title":"J Biol Chem"},{"issue":"16","key":"B65","doi-asserted-by":"crossref","first-page":"7747","DOI":"10.1016\/S0021-9258(18)68562-X","article-title":"Cyclic AMP stabilizes the mRNA for phosphoenolpyruvate carboxykinase (GTP) against degradation","volume":"263","author":"Hod","year":"1988","journal-title":"J Biol Chem"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E16-06-0379"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(93)90072-Y"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1159\/000063659"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.3109\/13816819609057889"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-12-04778.1999"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0606276103"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2008.92"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M105133200"},{"key":"B74","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2016.00046","article-title":"Death associated protein kinase 1 (DAPK1): a regulator of apoptosis and autophagy","volume":"9","author":"Singh","year":"2016","journal-title":"Front Mol Neurosci"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2008.121"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-0512"},{"key":"B77","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2015.00277","article-title":"Origins of spontaneous activity in the degenerating retina","volume":"9","author":"Trenholm","year":"2015","journal-title":"Front Cell Neurosci"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.225060"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2399-13.2013"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1412965"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1126\/science.1166226"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1089\/hum.1997.8.4-423"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2016.07.013"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.11.023"},{"key":"B85","article-title":"Establishment of a cone photoreceptor transplantation platform based on a novel cone-GFP reporter mouse line","volume":"6","author":"Smiley","year":"2016","journal-title":"Sci Rep"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-20-08799.1999"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/125898\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T17:31:22Z","timestamp":1695922282000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/125898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,16]]},"references-count":86,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,4,1]]},"published-print":{"date-parts":[[2020,4,1]]}},"alternative-id":["10.1172\/JCI125898"],"URL":"https:\/\/doi.org\/10.1172\/jci125898","relation":{},"ISSN":["0021-9738","1558-8238"],"issn-type":[{"value":"0021-9738","type":"print"},{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,16]]}}}