{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:52:08Z","timestamp":1791445928566,"version":"4.3.3"},"reference-count":42,"publisher":"American Society for Clinical Investigation","issue":"4","funder":[{"name":"NIH","award":["R01AG054559"],"award-info":[{"award-number":["R01AG054559"]}]},{"DOI":"10.13039\/100006312","name":"BrightFocus Foundation","doi-asserted-by":"crossref","award":["A2015504S"],"award-info":[{"award-number":["A2015504S"]}],"id":[{"id":"10.13039\/100006312","id-type":"DOI","asserted-by":"crossref"}]},{"name":"CurePSP & CBD","award":["520-14"],"award-info":[{"award-number":["520-14"]}]},{"DOI":"10.13039\/100006827","name":"Florida Department of Health","doi-asserted-by":"crossref","award":["5AZ11"],"award-info":[{"award-number":["5AZ11"]}],"id":[{"id":"10.13039\/100006827","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer\u2019s Association","doi-asserted-by":"crossref","award":["MNIRGD-12-242665"],"award-info":[{"award-number":["MNIRGD-12-242665"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,15]]},"DOI":"10.1172\/jci126299","type":"journal-article","created":{"date-parts":[[2021,2,14]],"date-time":"2021-02-14T19:01:17Z","timestamp":1613329277000},"source":"Crossref","is-referenced-by-count":48,"title":["Aberrant AZIN2 and polyamine metabolism precipitates tau neuropathology"],"prefix":"10.1172","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2463-7957","authenticated-orcid":false,"given":"Leslie A.","family":"Sandusky-Beltran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3105-1295","authenticated-orcid":false,"given":"Andrii","family":"Kovalenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devon S.","family":"Placides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Ratnasamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6970-5613","authenticated-orcid":false,"given":"Chao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Jerry B.","family":"Hunt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Ivan T.","family":"Calahatian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Michalski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6815-0529","authenticated-orcid":false,"given":"Margaret","family":"Fahnestock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4981-5564","authenticated-orcid":false,"given":"Laura J.","family":"Blair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"April L.","family":"Darling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy D.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah N.","family":"Fontaine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad A.","family":"Dickey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua J.","family":"Gamsby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8607-1832","authenticated-orcid":false,"given":"Kevin R.","family":"Nash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Abner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maj-Linda B.","family":"Selenica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel C.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2021,2,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70090-5"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2014.03.013"},{"key":"B3","doi-asserted-by":"crossref","DOI":"10.1038\/srep02364","article-title":"Metabolic profiling of Alzheimer\u2019s disease brains","volume":"3","author":"Inoue","year":"2013","journal-title":"Sci Rep"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.4161\/auto.26918"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2014.02.035"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3512"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2012.07778.x"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R500031200"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1080\/15216540500307031"},{"issue":"4\u20135","key":"B10","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1023\/A:1025036532672","article-title":"Overview of the brain polyamine-stress-response: regulation, development, and modulation by lithium and role in cell survival","volume":"23","author":"Gilad","year":"2003","journal-title":"Cell Mol Neurobiol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.4062\/biomolther.2012.097"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.53.070184.003533"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2009.1097"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-034-8_1"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2015.11.014"},{"issue":"pt 1","key":"B16","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1042\/bj3550045","article-title":"Characterization of the interaction between the transcription factors human polyamine modulated factor (PMF-1) and NF-E2-related factor 2 (Nrf-2) in the transcriptional regulation of the spermidine\/spermine N1-acetyltransferase (SSAT) gene","volume":"355","author":"Wang","year":"2001","journal-title":"Biochem J"},{"key":"B17","doi-asserted-by":"crossref","DOI":"10.1038\/srep06836","article-title":"Identification of a mammalian vesicular polyamine transporter","volume":"4","author":"Hiasa","year":"2014","journal-title":"Sci Rep"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvj003"},{"issue":"2\u20133","key":"B19","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1159\/000112681","article-title":"Polyamines in the developing mouse brain","volume":"5","author":"Jasper","year":"1982","journal-title":"Dev Neurosci"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2009.00334.x"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119452"},{"issue":"3","key":"B22","first-page":"211","article-title":"L-arginine and Alzheimer\u2019s disease","volume":"2","author":"Yi","year":"2009","journal-title":"Int J Clin Exp Pathol"},{"issue":"1","key":"B23","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1046\/j.1471-4159.1998.71010288.x","article-title":"Ornithine decarboxylase in human brain: influence of aging, regional distribution, and Alzheimer\u2019s disease","volume":"71","author":"Morrison","year":"1998","journal-title":"J Neurochem"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-019-0507-y"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.03.023"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.04.010"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2010.17"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145709991167"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015146"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021050"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.09.022"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2642-12.2013"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-018-02687-x"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.144089"},{"issue":"11","key":"B35","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/nrn960","article-title":"Calcium dyshomeostasis and intracellular signalling in Alzheimer\u2019s disease","volume":"3","author":"LaFerla","year":"2002","journal-title":"Nat Rev Neurosci"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2015.08.022"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.01.010"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2010.10.010"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059626"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3959-14.2015"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv135"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.637595"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/126299\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T06:00:13Z","timestamp":1697868013000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/126299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,15]]},"references-count":42,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,2,15]]},"published-print":{"date-parts":[[2021,2,15]]}},"alternative-id":["10.1172\/JCI126299"],"URL":"https:\/\/doi.org\/10.1172\/jci126299","relation":{},"ISSN":["0021-9738","1558-8238"],"issn-type":[{"value":"0021-9738","type":"print"},{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,15]]},"article-number":"e126299"}}