{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:18:03Z","timestamp":1790295483005,"version":"4.1.0"},"reference-count":74,"publisher":"American Society for Clinical Investigation","issue":"4","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","award":["T cell trafficking"],"award-info":[{"award-number":["T cell trafficking"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","award":["specificity in ankylosing spondylitis"],"award-info":[{"award-number":["specificity in ankylosing spondylitis"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,9]]},"DOI":"10.1172\/jci126567","type":"journal-article","created":{"date-parts":[[2020,3,8]],"date-time":"2020-03-08T22:02:32Z","timestamp":1583704952000},"page":"1863-1878","source":"Crossref","is-referenced-by-count":71,"title":["TYK2 inhibition reduces type 3 immunity and modifies disease progression in murine spondyloarthritis"],"prefix":"10.1172","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0984-435X","authenticated-orcid":false,"given":"Eric","family":"Gracey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7888-0090","authenticated-orcid":false,"given":"Dominika","family":"Hromadov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1698-0360","authenticated-orcid":false,"given":"Zoya","family":"Qaiyum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archita","family":"Srinath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuriy","family":"Baglaenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Yeremenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Westlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Masse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7879-3552","authenticated-orcid":false,"given":"Mathias","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5716-3212","authenticated-orcid":false,"given":"Birgit","family":"Strobl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyan","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Inman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2020,3,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1406182"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2017.12.008"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2002.004861"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270401"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/art.21972"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30949-8"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-018-0044-2"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.11.001"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2017.56"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/s40744-018-0106-6"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210023"},{"issue":"10","key":"B12","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1002\/art.38070","article-title":"The impact of tumor necrosis factor \u03b1 inhibitors on radiographic progression in ankylosing spondylitis","volume":"65","author":"Haroon","year":"2013","journal-title":"Arthritis Rheum"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209730"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/cti.2017.49"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.5RI0218-084R"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210322"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20140280"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201646519"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxr057"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003244"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0902740"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3528"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aag1974"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2667"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1203118"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-25282-2"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/nature22969"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7046"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0122271"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-34026-1"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1002\/art.34423"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1002\/art.38638"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06933-4"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2017.188"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209454"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/nature02119"},{"issue":"55","key":"B37","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3000448","article-title":"The inducible costimulator (ICOS) is critical for the development of human T(H)17 cells","volume":"2","author":"Paulos","year":"2010","journal-title":"Sci Transl Med"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1994.2902"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2817"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402565"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1002\/art.39732"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-25988-3"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003986"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3504"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039141"},{"issue":"105","key":"B46","article-title":"Interleukin-1 (IL-1) pathway","volume":"3","author":"Weber","year":"2010","journal-title":"Sci Signal"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-03-492157"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E14-12-1645"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1038\/nature13835"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1002\/art.39464"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1002\/art.24568"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.9.5948"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2017.201"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1806382"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaw1736"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400205"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1002\/art.40150"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1002\/art.33507"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3726"},{"issue":"JUN","key":"B60","article-title":"Human \u03b1\u03b2 and \u03b3\u03b4 T cells in skin immunity and disease","volume":"9","author":"Cruz","year":"2018","journal-title":"Front Immunol"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1038\/nature17655"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201142155"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1186\/ar1470"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.9.5652"},{"issue":"3","key":"B65","first-page":"488","article-title":"Interleukin-22 drives the proliferation, migration and osteogenic differentiation of mesenchymal stem cells: A novel cytokine that could contribute to new bone formation in spondyloarthropathies","volume":"56","author":"El-Zayadi","year":"2017","journal-title":"Rheumatol"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30952-8"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204248"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1002\/art.40728"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-213328"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1179\/2046905514Y.0000000119"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-018-0016-z"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2017.07.002"},{"key":"B73","doi-asserted-by":"crossref","DOI":"10.1186\/1741-7015-11-96","article-title":"Phosphodiesterase 4-targeted treatments for autoimmune diseases","volume":"11","author":"Kumar","year":"2013","journal-title":"BMC Med"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200859"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/126567\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T20:18:32Z","timestamp":1722543512000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/126567"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,9]]},"references-count":74,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,4,1]]},"published-print":{"date-parts":[[2020,4,1]]}},"alternative-id":["10.1172\/JCI126567"],"URL":"https:\/\/doi.org\/10.1172\/jci126567","relation":{},"ISSN":["0021-9738","1558-8238"],"issn-type":[{"value":"0021-9738","type":"print"},{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,9]]}}}