{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:14:39Z","timestamp":1793304879428,"version":"4.5.0"},"reference-count":43,"publisher":"American Society for Clinical Investigation","issue":"12","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81270441"],"award-info":[{"award-number":["81270441"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81200266"],"award-info":[{"award-number":["81200266"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Key Research and Development Project","award":["2016YFE0203900"],"award-info":[{"award-number":["2016YFE0203900"]}]},{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzhen","doi-asserted-by":"crossref","award":["SZSM201812055"],"award-info":[{"award-number":["SZSM201812055"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,11,3]]},"DOI":"10.1172\/jci126584","type":"journal-article","created":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T16:53:13Z","timestamp":1597769593000},"page":"6443-6456","source":"Crossref","is-referenced-by-count":59,"title":["Intestinal proinflammatory macrophages induce a phenotypic switch in interstitial cells of Cajal"],"prefix":"10.1172","volume":"130","author":[{"given":"Xuyong","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyao","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenzhao","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid Mohamoud","family":"Abdullahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jixin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlei","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail E.","family":"Besner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiexiong","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2020,11,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e328360c2a0"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-013-3353-1"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.183433"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-5895-1_1"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(95)90051-9"},{"issue":"8","key":"B6","doi-asserted-by":"crossref","first-page":"928","DOI":"10.5858\/2002-126-0928-ADOICO","article-title":"Altered distribution of interstitial cells of Cajal in Hirschsprung disease","volume":"126","author":"Rolle","year":"2002","journal-title":"Arch Pathol Lab Med"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-013-3364-y"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(98)90152-X"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.68.040504.094718"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-008-2207-4"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-013-1775-7"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201141714"},{"issue":"6","key":"B13","first-page":"1297","article-title":"Monocyte and M1 macrophage-induced barrier defect contributes to chronic intestinal inflammation in IBD","volume":"21","author":"Lissner","year":"2015","journal-title":"Inflamm Bowel Dis"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2015.03.023"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.07.030"},{"issue":"4","key":"B16","doi-asserted-by":"crossref","DOI":"10.1111\/nmo.12984","article-title":"Tumor necrosis factor alpha derived from classically activated \u201cM1\u201d macrophages reduces interstitial cell of Cajal numbers","volume":"29","author":"Eisenman","year":"2017","journal-title":"Neurogastroenterol Motil"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(95)90334-8"},{"issue":"7","key":"B18","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/0092-8674(94)90017-5","article-title":"Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice","volume":"79","author":"Hosoda","year":"1994","journal-title":"Cell"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2009.10.035"},{"issue":"7","key":"B20","first-page":"3159","article-title":"Calretinin, S100 and protein gene product 9.5 immunostaining of rectal suction biopsies in the diagnosis of Hirschsprung\u2019 disease","volume":"8","author":"Jiang","year":"2016","journal-title":"Am J Transl Res"},{"issue":"3","key":"B21","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1097\/00129039-200209000-00005","article-title":"Detection of ganglion cells in the colonic plexuses by immunostaining for neuron-specific marker NeuN: an aid for the diagnosis of Hirschsprung disease","volume":"10","author":"Yang","year":"2002","journal-title":"Appl Immunohistochem Mol Morphol"},{"issue":"2","key":"B22","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1111\/jcmm.13375","article-title":"Development of interstitial cells of Cajal in the human digestive tract as the result of reciprocal induction of mesenchymal and neural crest cells","volume":"22","author":"Radenkovic","year":"2018","journal-title":"J Cell Mol Med"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00074.2009"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002701"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.07.009"},{"issue":"66","key":"B26","doi-asserted-by":"crossref","DOI":"10.3791\/4105","article-title":"Depletion and reconstitution of macrophages in mice","author":"Weisser","year":"2012","journal-title":"J Vis Exp"},{"key":"B27","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms2626","article-title":"Interstitial cells of Cajal integrate excitatory and inhibitory neurotransmission with intestinal slow-wave activity","volume":"4","author":"Klein","year":"2013","journal-title":"Nat Commun"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2011.01089.x"},{"issue":"1","key":"B29","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s00418-006-0223-0","article-title":"Possible involvement of muscularis resident macrophages in impairment of interstitial cells of Cajal and myenteric nerve systems in rat models of TNBS-induced colitis","volume":"127","author":"Kinoshita","year":"2007","journal-title":"Histochem Cell Biol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12418"},{"issue":"11","key":"B31","first-page":"4099","article-title":"Decreased SCF\/c-kit signaling pathway contributes to loss of interstitial cells of Cajal in gallstone disease","volume":"7","author":"Tan","year":"2014","journal-title":"Int J Clin Exp Med"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1186\/scrt387"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2017.68"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1002\/bies.10039"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1071128"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-017-4182-4"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-0166"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2011.11.008"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506216102"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1136\/gut.33.6.801"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2010.01025.x"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2009.06.009"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.08.026"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/126584\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T22:55:47Z","timestamp":1696546547000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/126584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,3]]},"references-count":43,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2020,12,1]]},"published-print":{"date-parts":[[2020,12,1]]}},"alternative-id":["10.1172\/JCI126584"],"URL":"https:\/\/doi.org\/10.1172\/jci126584","relation":{},"ISSN":["0021-9738","1558-8238"],"issn-type":[{"value":"0021-9738","type":"print"},{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,3]]}}}