{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T11:11:29Z","timestamp":1792667489224,"version":"4.5.0"},"reference-count":200,"publisher":"American Society for Clinical Investigation","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,2]]},"DOI":"10.1172\/jci127201","type":"journal-article","created":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T18:00:51Z","timestamp":1562004051000},"page":"3006-3017","source":"Crossref","is-referenced-by-count":475,"title":["Adipocyte and lipid metabolism in cancer drug resistance"],"prefix":"10.1172","volume":"129","author":[{"given":"Yihai","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2019,7,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1160809"},{"key":"B2","doi-asserted-by":"crossref","DOI":"10.1038\/oncsis.2015.49","article-title":"Lipid metabolic reprogramming in cancer cells","volume":"5","author":"Beloribi-Djefaflia","year":"2016","journal-title":"Oncogenesis"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.05.005"},{"issue":"2","key":"B4","first-page":"369","article-title":"Dominant uptake of fatty acid over glucose by prostate cells: a potential new diagnostic and therapeutic approach","volume":"30","author":"Liu","year":"2010","journal-title":"Anticancer Res"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2012.08.014"},{"key":"B6","article-title":"Direct visualization of de novo lipogenesis in single living cells","volume":"4","author":"Li","year":"2014","journal-title":"Sci Rep"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/nature20791"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.01.019"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-12-0485"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-010-0990-0"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-2636"},{"key":"B12","doi-asserted-by":"crossref","DOI":"10.1186\/s40170-016-0163-7","article-title":"Adipocyte lipolysis links obesity to breast cancer growth: adipocyte-derived fatty acids drive breast cancer cell proliferation and migration","volume":"5","author":"Balaban","year":"2017","journal-title":"Cancer Metab"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.06.101"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-3323"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-13-0530"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ando.2013.02.007"},{"issue":"1","key":"B17","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41574-018-0123-0","article-title":"Inter-tissue communication in cancer cachexia","volume":"15","author":"Argil\u00e9s","year":"2018","journal-title":"Nat Rev Endocrinol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbo.2016.03.006"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aag0945"},{"issue":"10","key":"B20","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1016\/j.bbalip.2013.02.010","article-title":"Adipose tissue and adipocytes support tumorigenesis and metastasis","volume":"1831","author":"Nieman","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.2174\/138955751513150923094709"},{"key":"B22","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms10230","article-title":"Periprostatic adipocytes act as a driving force for prostate cancer progression in obesity","volume":"7","author":"Laurent","year":"2016","journal-title":"Nat Commun"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3829"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.06.011"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2492"},{"key":"B26","article-title":"Adipocytes promote malignant growth of breast tumours with monocarboxylate transporter 2 expression via \u03b2-hydroxybutyrate","volume":"8","author":"Huang","year":"2017","journal-title":"Nat Commun"},{"issue":"1","key":"B27","article-title":"Hematopoietic stem cell-derived adipocytes promote tumor growth and cancer cell migration","volume":"3","author":"Xiong","year":"2017","journal-title":"Int J Cancer Res Mol Mech"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-018-0221-6"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-17-1371"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2017.11.002"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2017.357"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-018-0477-8"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S199597"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1042\/CS20181023"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3818"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-1603"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2628"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/nature10138"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1038\/362841a0"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1042\/BST20160069"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1889"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3215"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3603"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.03.015"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2016.12.002"},{"issue":"8","key":"B46","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1515\/BC.2008.110","article-title":"Cancer cells, adipocytes and matrix metalloproteinase 11: a vicious tumor progression cycle","volume":"389","author":"Motrescu","year":"2008","journal-title":"Biol Chem"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1172\/JCI32239"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.10.002"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v8.i9.422"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2013.434"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1256"},{"key":"B52","article-title":"The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages","volume":"7","author":"Yang","year":"2016","journal-title":"Nat Commun"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2009.06.006"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3038"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1126\/science.123.3191.309"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2006.05.012"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23081941"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.07.010"},{"key":"B59","doi-asserted-by":"crossref","DOI":"10.1186\/1476-4598-10-70","article-title":"The metabolic advantage of tumor cells","volume":"10","author":"Isra\u00ebl","year":"2011","journal-title":"Mol Cancer"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2222"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-4112"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-4673"},{"issue":"9","key":"B63","doi-asserted-by":"crossref","first-page":"7348","DOI":"10.18632\/oncotarget.3130","article-title":"ColoLipidGene: signature of lipid metabolism-related genes to predict prognosis in stage-II colon cancer patients","volume":"6","author":"Vargas","year":"2015","journal-title":"Oncotarget"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1038\/nature03253"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.06.049"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-017-0093-z"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1987211"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-3281"},{"issue":"12","key":"B69","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/j.bbamcr.2006.08.034","article-title":"Peroxisomal beta-oxidation\u2014a metabolic pathway with multiple functions","volume":"1763","author":"Poirier","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3483"},{"issue":"5","key":"B71","doi-asserted-by":"crossref","DOI":"10.1038\/nrd.2016.76","article-title":"Breast cancer: inhibiting fatty acid oxidation blocks tumour growth","volume":"15","author":"Crunkhorn","year":"2016","journal-title":"Nat Rev Drug Discov"},{"key":"B72","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/291546","article-title":"Obesity as a major risk factor for cancer","volume":"2013","author":"De Pergola","year":"2013","journal-title":"J Obes"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-nutr-071811-150713"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.01021.x"},{"key":"B75","doi-asserted-by":"crossref","DOI":"10.1186\/s12967-016-0772-5","article-title":"Obesity and colorectal cancer: molecular features of adipose tissue","volume":"14","author":"Martinez-Useros","year":"2016","journal-title":"J Transl Med"},{"issue":"20","key":"B76","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.122375","article-title":"Molecular mechanisms of IL-33-mediated stromal interactions in cancer metastasis","volume":"3","author":"Andersson","year":"2018","journal-title":"JCI Insight"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-17-0101"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-5616"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.2174\/138161208784246153"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i18.5177"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1172\/JCI92035"},{"issue":"34","key":"B82","doi-asserted-by":"crossref","first-page":"57622","DOI":"10.18632\/oncotarget.18038","article-title":"The fat and the bad: mature adipocytes, key actors in tumor progression and resistance","volume":"8","author":"Duong","year":"2017","journal-title":"Oncotarget"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1038\/369414a0"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1172\/JCI80046"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2014.10.008"},{"issue":"4","key":"B86","doi-asserted-by":"crossref","DOI":"10.1002\/dmrr.2868","article-title":"Diabetes mellitus and long-term mortality of ovarian cancer patients. A systematic review and meta-analysis of 12 cohort studies","volume":"33","author":"Zhang","year":"2017","journal-title":"Diabetes Metab Res Rev"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000132745.76882.70"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1415825111"},{"issue":"25","key":"B89","doi-asserted-by":"crossref","first-page":"38282","DOI":"10.18632\/oncotarget.9436","article-title":"Co-option of pre-existing vascular beds in adipose tissue controls tumor growth rates and angiogenesis","volume":"7","author":"Lim","year":"2016","journal-title":"Oncotarget"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04987-y"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-17-2465"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.07.006"},{"issue":"13","key":"B93","first-page":"1262","article-title":"Osimertinib in EGFR mutation\u2013positive advanced NSCLC","volume":"378","author":"Choi","year":"2018","journal-title":"N Engl J Med"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200409163511221"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0910383"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2817"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20120162"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b00168"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.13.151"},{"issue":"114","key":"B100","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3003149","article-title":"Forty-year journey of angiogenesis translational research","volume":"3","author":"Cao","year":"2011","journal-title":"Sci Transl Med"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197111182852108"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032691"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa072113"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-17-0874"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1800913"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1704610"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1200694"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe1205943"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1412082"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc0800250"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1159\/000365306"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-017-0257-y"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604057"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.047563"},{"issue":"3","key":"B115","article-title":"Megestrol acetate for treatment of anorexia-cachexia syndrome","author":"Ruiz Garcia","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0102436"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2017-000458"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24230"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1408"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2009.0009"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1159\/000148914"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1210\/en.2006-0311"},{"key":"B123","doi-asserted-by":"crossref","first-page":"105","DOI":"10.4137\/CMO.S32812","article-title":"Obesity correlation with metastases development and response to first-line metastatic chemotherapy in breast cancer","volume":"9","author":"Osman","year":"2015","journal-title":"Clin Med Insights Oncol"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-48382-5_25"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2008.11.009"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.49.5.797"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-48382-5_13"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1038\/375577a0"},{"key":"B129","doi-asserted-by":"crossref","first-page":"3962","DOI":"10.2741\/3504","article-title":"Tumor angiogenesis and molecular targets for therapy","volume":"14","author":"Cao","year":"2009","journal-title":"Front Biosci (Landmark Ed)"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1126\/science.1104819"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.05.014"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.08.008"},{"key":"B133","doi-asserted-by":"crossref","DOI":"10.1186\/s13058-015-0569-0","article-title":"Adipose cells promote resistance of breast cancer cells to trastuzumab-mediated antibody-dependent cellular cytotoxicity","volume":"17","author":"Duong","year":"2015","journal-title":"Breast Cancer Res"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2010.01.007"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2011.104"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.2174\/138920011794520035"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.2165\/11318100-000000000-00000"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2011.11.023"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.12581"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.5507\/bp.2015.025"},{"key":"B141","doi-asserted-by":"crossref","DOI":"10.1186\/1476-4598-12-152","article-title":"Tumor glycolysis as a target for cancer therapy: progress and prospects","volume":"12","author":"Ganapathy-Kanniappan","year":"2013","journal-title":"Mol Cancer"},{"issue":"26","key":"B142","doi-asserted-by":"crossref","first-page":"18239","DOI":"10.18632\/oncotarget.24435","article-title":"Leptin-Notch axis impairs 5-fluorouracil effects on pancreatic cancer","volume":"9","author":"Harbuzariu","year":"2018","journal-title":"Oncotarget"},{"issue":"11","key":"B143","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19113331","article-title":"Pancreatic cancer and obesity: molecular mechanisms of cell transformation and chemoresistance","volume":"19","author":"Cascetta","year":"2018","journal-title":"Int J Mol Sci"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.07.008"},{"key":"B145","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12680","article-title":"Discontinuation of anti-VEGF cancer therapy promotes metastasis through a liver revascularization mechanism","volume":"7","author":"Yang","year":"2016","journal-title":"Nat Commun"},{"issue":"11","key":"B146","doi-asserted-by":"crossref","first-page":"18280","DOI":"10.18632\/oncotarget.15430","article-title":"Extra-pancreatic invasion induces lipolytic and fibrotic changes in the adipose microenvironment, with released fatty acids enhancing the invasiveness of pancreatic cancer cells","volume":"8","author":"Okumura","year":"2017","journal-title":"Oncotarget"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.23623"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.2174\/0929867321666131129114742"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.45"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1677\/ERC-10-0083"},{"key":"B151","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11150","article-title":"Exosomal transfer of stroma-derived miR21 confers paclitaxel resistance in ovarian cancer cells through targeting APAF1","volume":"7","author":"Au Yeung","year":"2016","journal-title":"Nat Commun"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-0800"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2012.12.013"},{"issue":"45","key":"B154","doi-asserted-by":"crossref","first-page":"73147","DOI":"10.18632\/oncotarget.12246","article-title":"Adipocytes cause leukemia cell resistance to daunorubicin via oxidative stress response","volume":"7","author":"Sheng","year":"2016","journal-title":"Oncotarget"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-4402"},{"key":"B156","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2014.00053","article-title":"The role of adipose tissue and obesity in causing treatment resistance of acute lymphoblastic leukemia","volume":"2","author":"Sheng","year":"2014","journal-title":"Front Pediatr"},{"issue":"33","key":"B157","doi-asserted-by":"crossref","first-page":"34329","DOI":"10.18632\/oncotarget.6020","article-title":"Mature adipocytes in bone marrow protect myeloma cells against chemotherapy through autophagy activation","volume":"6","author":"Liu","year":"2015","journal-title":"Oncotarget"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.07.7792"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2015.1076815"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.115.124586"},{"issue":"15","key":"B161","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3000399","article-title":"Optimizing the delivery of cancer drugs that block angiogenesis","volume":"2","author":"Cao","year":"2010","journal-title":"Sci Transl Med"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1303989"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra040958"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2442"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2009.05.001"},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1209310110"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1016220108"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1126\/science.1193494"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2017.11.002"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.02.004"},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.188946"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2010-0227"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.1007\/s11523-014-0334-9"},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2011-0213"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2008.12.004"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2005.09.005"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3333"},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0042224"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2012.04.033"},{"issue":"1\u20133","key":"B180","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0300-483X(00)00279-1","article-title":"Oxidative damage to mitochondria in normal and cancer tissues, and its modulation","volume":"155","author":"Kamat","year":"2000","journal-title":"Toxicology"},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2009.264"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.1089\/met.2015.0095"},{"key":"B183","doi-asserted-by":"publisher","DOI":"10.1172\/JCI21625"},{"key":"B184","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-48382-5_9"},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2017.02.022"},{"issue":"1","key":"B186","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41574-018-0096-z","article-title":"The role of hypoxia-inducible factors in metabolic diseases","volume":"15","author":"Gonzalez","year":"2018","journal-title":"Nat Rev Endocrinol"},{"key":"B187","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/5350267","article-title":"Hypoxia in obesity and diabetes: potential therapeutic effects of hyperoxia and nitrate","volume":"2017","author":"Norouzirad","year":"2017","journal-title":"Oxid Med Cell Longev"},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.7150\/jca.16884"},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.1113\/JP273312"},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.1667\/RR14551.1"},{"key":"B191","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2011.01383.x"},{"issue":"1","key":"B192","first-page":"22","article-title":"Esophageal cancer","volume":"95","author":"Short","year":"2017","journal-title":"Am Fam Physician"},{"key":"B193","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2016.344"},{"key":"B194","doi-asserted-by":"publisher","DOI":"10.1177\/107327481302000203"},{"issue":"23","key":"B195","doi-asserted-by":"crossref","first-page":"10115","DOI":"10.7314\/APJCP.2014.15.23.10115","article-title":"IGF-1 from adipose-derived mesenchymal stem cells promotes radioresistance of breast cancer cells","volume":"15","author":"Yang","year":"2014","journal-title":"Asian Pac J Cancer Prev"},{"key":"B196","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-016-3923-8"},{"key":"B197","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2016.05.013"},{"key":"B198","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-014-2977-8"},{"key":"B199","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0191571"},{"key":"B200","doi-asserted-by":"publisher","DOI":"10.2174\/1875692111311010006"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/127201\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T13:29:10Z","timestamp":1691069350000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/127201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,2]]},"references-count":200,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2019,8,1]]},"published-print":{"date-parts":[[2019,8,1]]}},"alternative-id":["10.1172\/JCI127201"],"URL":"https:\/\/doi.org\/10.1172\/jci127201","relation":{},"ISSN":["0021-9738","1558-8238"],"issn-type":[{"value":"0021-9738","type":"print"},{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,2]]}}}