{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:55:19Z","timestamp":1790816119578,"version":"4.1.0"},"reference-count":89,"publisher":"American Society for Clinical Investigation","issue":"1","funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"crossref","award":["DK043140"],"award-info":[{"award-number":["DK043140"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Institute of Health","award":["GM008322"],"award-info":[{"award-number":["GM008322"]}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"crossref","award":["16PRE29620010"],"award-info":[{"award-number":["16PRE29620010"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,11,18]]},"DOI":"10.1172\/jci127429","type":"journal-article","created":{"date-parts":[[2019,11,17]],"date-time":"2019-11-17T18:00:52Z","timestamp":1574013652000},"page":"83-93","source":"Crossref","is-referenced-by-count":24,"title":["Chemogenetic activation of adrenocortical Gq signaling causes hyperaldosteronism and disrupts functional zonation"],"prefix":"10.1172","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4385-0681","authenticated-orcid":false,"given":"Matthew J.","family":"Taylor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Ullenbruch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily C.","family":"Frucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2593-5008","authenticated-orcid":false,"given":"Juilee","family":"Rege","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S.","family":"Ansorge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9882-2082","authenticated-orcid":false,"given":"Celso E.","family":"Gomez-Sanchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salma","family":"Begum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Laufer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David T.","family":"Breault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William E.","family":"Rainey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2019,11,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2013.07.016"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0081865"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0451fje"},{"issue":"5","key":"B4","first-page":"585","article-title":"Variegated expression of a mouse steroid 21-hydroxylase\/beta- galactosidase transgene suggests centripetal migration of adrenocortical cells","volume":"10","author":"Morley","year":"1996","journal-title":"Mol Endocrinol"},{"issue":"5","key":"B5","first-page":"519","article-title":"A study of cell migration in the adrenal cortex of the rat using bromodeoxyuridine","volume":"20","author":"McNicol","year":"1987","journal-title":"Cell Tissue Kinet"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1110477"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.0870001"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2016.09.003"},{"issue":"Pt 2","key":"B9","first-page":"375","article-title":"Cell proliferation and renewal of mouse adrenal cortex","volume":"188","author":"Kataoka","year":"1996","journal-title":"J Anat"},{"issue":"6 Pt 2","key":"B10","first-page":"F751","article-title":"Ca2+\/calmodulin-dependent protein kinase II activation and regulation of adrenal glomerulosa Ca2+ signaling","volume":"269","author":"Fern","year":"1995","journal-title":"Am J Physiol"},{"issue":"4","key":"B11","first-page":"417","article-title":"Role of calcium and other mediators in aldosterone secretion from the adrenal glomerulosa cells","volume":"46","author":"Ganguly","year":"1994","journal-title":"Pharmacol Rev"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1210\/endo.133.4.8404594"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1210\/endo-128-1-231"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1210\/endo-126-2-1001"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-10-4-496"},{"issue":"23","key":"B16","doi-asserted-by":"crossref","first-page":"14448","DOI":"10.1016\/S0021-9258(17)42620-2","article-title":"The temporal integration of the aldosterone secretory response to angiotensin occurs via two intracellular pathways","volume":"259","author":"Kojima","year":"1984","journal-title":"J Biol Chem"},{"issue":"21","key":"B17","doi-asserted-by":"crossref","first-page":"11093","DOI":"10.1016\/S0021-9258(19)68560-1","article-title":"Effects of angiotensin-II and potassium on phospholipid metabolism in the adrenal zona glomerulosa","volume":"256","author":"Farese","year":"1981","journal-title":"J Biol Chem"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1210\/me.2003-0005"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1080\/07435809609043718"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.01.052"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1295438"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.07.059"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1001554"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000040261.30455.B6"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1001013"},{"issue":"5","key":"B26","first-page":"1863","article-title":"Primary hyperaldosteronism in essential hypertensives: prevalence, biochemical profile, and molecular biology","volume":"85","author":"Fardella","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.01060"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-2805"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2007.33"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.01.015"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-008-0616-0"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.31.363"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000121426.43044.2B"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000080521.15238.E5"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.2000.1129"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1210\/en.2017-00637"},{"key":"B37","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1146\/annurev-pharmtox-010814-124803","article-title":"DREADDs (designer receptors exclusively activated by designer drugs): chemogenetic tools with therapeutic utility","volume":"55","author":"Urban","year":"2015","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0700293104"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.03.065"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2013.261289"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1210\/en.2012-2127"},{"issue":"191","key":"B42","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2002221","article-title":"A synthetic biology approach reveals a CXCR4-G13-Rho signaling axis driving transendothelial migration of metastatic breast cancer cells","volume":"4","author":"Yagi","year":"2011","journal-title":"Sci Signal"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.10.018"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1172\/JCI74664"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0906593106"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1172\/JCI66432"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.10.061"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.06.014"},{"issue":"2","key":"B49","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.98394","article-title":"PKA signaling drives reticularis differentiation and sexually dimorphic adrenal cortex renewal","volume":"3","author":"Dumontet","year":"2018","journal-title":"JCI Insight"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1210\/en.2018-00769"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1210\/en.2006-1509"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1210\/me.2014-1060"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq029"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1242\/dev.021493"},{"key":"B55","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12751","article-title":"PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development","volume":"7","author":"Drelon","year":"2016","journal-title":"Nat Commun"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1210\/en.2017-03061"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt484"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1101\/gad.317412.118"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1210\/endo.132.6.8389287"},{"issue":"23","key":"B60","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.97128","article-title":"The E3 ubiquitin ligase Siah1 regulates adrenal gland organization and aldosterone secretion","volume":"2","author":"Scortegagna","year":"2017","journal-title":"JCI Insight"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-00746"},{"key":"B62","article-title":"The prevalence of CTNNB1 mutations in primary aldosteronism and consequences for clinical outcomes","volume":"7","author":"Wu","year":"2017","journal-title":"Sci Rep"},{"key":"B63","doi-asserted-by":"crossref","DOI":"10.1038\/srep19546","article-title":"Activating mutations in CTNNB1 in aldosterone producing adenomas","volume":"6","author":"\u00c5kerstr\u00f6m","year":"2016","journal-title":"Sci Rep"},{"issue":"2","key":"B64","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1111\/j.1365-2265.2007.03033.x","article-title":"Frequent mutations of beta-catenin gene in sporadic secreting adrenocortical adenomas","volume":"68","author":"Tadjine","year":"2008","journal-title":"Clin Endocrinol (Oxf)"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-0593"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1243601"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601934"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0712000105"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds333"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1210\/en.2012-1527"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.189662"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0904635106"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000156448.74296.FE"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2061"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010-1081"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.098897"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-00461-9"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-0814"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00458.2005"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2018.01.003"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-1298"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1340"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-08-0711"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1504869"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2019.04.012"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1349881"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.02504"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2010.11.010"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01089.2003"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/127429\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T22:42:23Z","timestamp":1722033743000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/127429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,18]]},"references-count":89,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,1,2]]},"published-print":{"date-parts":[[2020,1,2]]}},"alternative-id":["10.1172\/JCI127429"],"URL":"https:\/\/doi.org\/10.1172\/jci127429","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.736931179.793568180","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.736931179.793578066","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.736931179.793569097","asserted-by":"object"}]},"ISSN":["0021-9738","1558-8238"],"issn-type":[{"value":"0021-9738","type":"print"},{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,18]]}}}