{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T01:15:17Z","timestamp":1789953317221,"version":"4.0.1"},"reference-count":48,"publisher":"American Society for Clinical Investigation","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Invest."],"published-print":{"date-parts":[[2001,8,15]]},"DOI":"10.1172\/jci200113077","type":"journal-article","created":{"date-parts":[[2002,7,28]],"date-time":"2002-07-28T23:19:50Z","timestamp":1027898390000},"page":"537-546","source":"Crossref","is-referenced-by-count":108,"title":["Endothelium-specific loss of murine thrombomodulin disrupts the protein C anticoagulant pathway and causes juvenile-onset thrombosis"],"prefix":"10.1172","volume":"108","author":[{"given":"Berend","family":"Isermann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara B.","family":"Hendrickson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Zogg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Wing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjorie","family":"Cummiskey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaz Y.","family":"Kisanuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Yanagisawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hartmut","family":"Weiler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3029867"},{"key":"B2","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0167-4838(99)00266-6","volume":"1477","author":"Esmon","year":"2000","journal-title":"Biochim Biophys Acta"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.28.16603"},{"key":"B4","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1056\/NEJM200103083441001","volume":"334","author":"Bernard","year":"2001","journal-title":"N Engl J Med"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112902"},{"key":"B6","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1182\/blood.V78.2.357.357","volume":"78","author":"Taylor","year":"1991","journal-title":"Blood"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/s001340050519"},{"key":"B8","first-page":"363","volume":"84","author":"Esmon","year":"1999","journal-title":"Haematologica"},{"key":"B9","doi-asserted-by":"crossref","first-page":"3531","DOI":"10.1182\/blood.V87.9.3531.bloodjournal8793531","volume":"87","author":"Stefano","year":"1996","journal-title":"Blood"},{"key":"B10","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1182\/blood.V65.1.15.15","volume":"65","author":"Marciniak","year":"1985","journal-title":"Blood"},{"key":"B11","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1055\/s-2007-1002683","volume":"16","author":"Marlar","year":"1990","journal-title":"Semin Thromb Hemost"},{"key":"B12","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1182\/blood.V95.2.569","volume":"95","author":"Kunz","year":"2000","journal-title":"Blood"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)09057-6"},{"key":"B14","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1055\/s-0038-1657559","volume":"78","author":"Ohlin","year":"1997","journal-title":"Thromb Haemost"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.3.850"},{"key":"B16","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1242\/dev.128.6.827","volume":"128","author":"Isermann","year":"2001","journal-title":"Development"},{"key":"B17","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1161\/01.RES.78.2.180","volume":"78","author":"Weiler-Guettler","year":"1996","journal-title":"Circ Res"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2000.0106"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.6.1685"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051142"},{"key":"B21","doi-asserted-by":"crossref","first-page":"E685","DOI":"10.1152\/ajpendo.2001.280.5.E685","volume":"280","author":"Wautier","year":"2001","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1172\/JCI2006"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1097\/00001721-199507000-00012"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(97)00015-7"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041220124"},{"key":"B26","doi-asserted-by":"crossref","first-page":"4222","DOI":"10.1182\/blood.V96.13.4222","volume":"96","author":"Cui","year":"2000","journal-title":"Blood"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1172\/JCI3011"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1172\/JCI9095"},{"key":"B29","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0002-9440(10)63989-2","volume":"158","author":"Chan","year":"2001","journal-title":"Am J Pathol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0177(2000)9999:9999<::aid-dvdy1080>3.0.CO;2-N<\/::aid-dvdy1080>"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/6.1.81"},{"key":"B32","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1016\/S0002-9440(10)65089-4","volume":"156","author":"Dunk","year":"2000","journal-title":"Am J Pathol"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119388"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.15.6861"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)90003-Y"},{"key":"B36","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1182\/blood.V95.6.1935","volume":"95","author":"Makris","year":"2000","journal-title":"Blood"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1989.tb07686.x"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2257.1997.tb00010.x"},{"key":"B39","first-page":"2364","volume":"96","author":"Janssen","year":"2000","journal-title":"Blood"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.66.6.460"},{"key":"B41","first-page":"18","volume":"98","author":"Truhlar","year":"1998","journal-title":"Kans Med"},{"key":"B42","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1182\/blood.V80.8.1998.1998","volume":"80","author":"Andrew","year":"1992","journal-title":"Blood"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/S0531-5565(98)00047-3"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.1222936.x"},{"key":"B45","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1161\/01.ATV.16.9.1170","volume":"16","author":"Scarabin","year":"1996","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B46","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1182\/blood.V75.2.329.329","volume":"75","author":"Dittman","year":"1990","journal-title":"Blood"},{"key":"B47","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1182\/blood.V90.3.944","volume":"90","author":"Huang","year":"1997","journal-title":"Blood"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1172\/JCI10489"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.jci.org\/articles\/view\/13077\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T16:41:25Z","timestamp":1691080885000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jci.org\/articles\/view\/13077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,8,15]]},"references-count":48,"aliases":["10.1172\/jci13077"],"journal-issue":{"issue":"4","published-print":{"date-parts":[[2001,8,15]]}},"URL":"https:\/\/doi.org\/10.1172\/jci200113077","relation":{},"ISSN":["0021-9738"],"issn-type":[{"value":"0021-9738","type":"print"}],"subject":[],"published":{"date-parts":[[2001,8,15]]}}}