{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:44:24Z","timestamp":1790318664285,"version":"4.1.0"},"reference-count":32,"publisher":"American Society for Clinical Investigation","issue":"2","funder":[{"name":"National Center for Advancing Translational Sciences of the National Institutes of Health","award":["KL2 TR000458"],"award-info":[{"award-number":["KL2 TR000458"]}]},{"name":"National Center for Advancing Translational Sciences of the National Institutes of Health","award":["UL1-TR00457"],"award-info":[{"award-number":["UL1-TR00457"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,13]]},"DOI":"10.1172\/jci130860","type":"journal-article","created":{"date-parts":[[2020,1,12]],"date-time":"2020-01-12T18:01:06Z","timestamp":1578852066000},"page":"921-926","source":"Crossref","is-referenced-by-count":71,"title":["Decreased sphingolipid synthesis in children with 17q21 asthma\u2013risk genotypes"],"prefix":"10.1172","volume":"130","author":[{"given":"Jennie G.","family":"Ono","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin I.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yize","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Christos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3997-5839","authenticated-orcid":false,"given":"Yohannes","family":"Tesfaigzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tilla S.","family":"Worgall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Worgall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2020,1,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06014"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu479"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2009.08.007"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.12.974"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.03.015"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201507-1493OC"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1211592"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbior.2018.08.002"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/nature08787"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.007291"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2329"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1303047"},{"issue":"186","key":"B13","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3005765","article-title":"Impaired sphingolipid synthesis in the respiratory tract induces airway hyperreactivity","volume":"5","author":"Worgall","year":"2013","journal-title":"Sci Transl Med"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.08.053"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201609-1884LE"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2019.11.3.330"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.02.031"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.06.017"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/nature13475"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ai.2017.06.001"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003029"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1126\/science.1262110"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1111\/all.12683"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.03.014"},{"key":"B25","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms13426","article-title":"17q21 asthma-risk variants switch CTCF binding and regulate IL-2 production by T cells","volume":"7","author":"Schmiedel","year":"2016","journal-title":"Nat Commun"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200711-1644OC"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201600639R"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.07.033"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201803-0438OC"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2012.01.027"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.D078535"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2014.03.012"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/130860\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T13:31:57Z","timestamp":1691069517000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/130860"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,13]]},"references-count":32,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,12,17]]},"published-print":{"date-parts":[[2019,12,17]]}},"alternative-id":["10.1172\/JCI130860"],"URL":"https:\/\/doi.org\/10.1172\/jci130860","relation":{},"ISSN":["0021-9738","1558-8238"],"issn-type":[{"value":"0021-9738","type":"print"},{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,13]]}}}