{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:31:37Z","timestamp":1791595897238,"version":"4.3.4"},"reference-count":81,"publisher":"American Society for Clinical Investigation","issue":"5","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["AI31798,AI147845,1UM1AI26617,AI117970"],"award-info":[{"award-number":["AI31798,AI147845,1UM1AI26617,AI117970"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,13]]},"DOI":"10.1172\/jci132374","type":"journal-article","created":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T12:03:20Z","timestamp":1580990600000},"page":"2542-2559","source":"Crossref","is-referenced-by-count":125,"title":["BCL-2 antagonism sensitizes cytotoxic T cell\u2013resistant HIV reservoirs to elimination ex vivo"],"prefix":"10.1172","volume":"130","author":[{"given":"Yanqin","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szu Han","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4782-9540","authenticated-orcid":false,"given":"Shabnum","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4097-9861","authenticated-orcid":false,"given":"Winiffer D. Conce","family":"Alberto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean","family":"Magat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dughan","family":"Ahimovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda B.","family":"Macedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Durga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dora","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Zale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talia M.","family":"Mota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Truong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Rohwetter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9178-2110","authenticated-orcid":false,"given":"Chase D.","family":"McCann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin M.","family":"Kovacs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Benko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6124-5162","authenticated-orcid":false,"given":"Avery","family":"Wimpelberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Cannon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. David","family":"Hardy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8800-2160","authenticated-orcid":false,"given":"Alberto","family":"Bosque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5140-9090","authenticated-orcid":false,"given":"Catherine M.","family":"Bollard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Brad","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2020,4,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00865-13"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.10.6130"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-12-4818"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0030403"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01754-06"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.08.018"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1172\/JCI80566"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.71.4.3120-3128.1997"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.10.010"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/nm1295-1284"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5341.1295"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5341.1291"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.01.014"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/487439a"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005142"},{"issue":"1","key":"B16","doi-asserted-by":"crossref","DOI":"10.1093\/ofid\/ofv037","article-title":"Activation of latent human immunodeficiency virus by the histone deacetylase inhibitor panobinostat: a pilot study to assess effects on the central nervous system","volume":"2","author":"Rasmussen","year":"2015","journal-title":"Open Forum Infect Dis"},{"issue":"1","key":"B17","doi-asserted-by":"crossref","DOI":"10.1016\/S2352-3018(14)70014-1","article-title":"Panobinostat, a histone deacetylase inhibitor, for latent-virus reactivation in HIV-infected patients on suppressive antiretroviral therapy: a phase 1\/2, single group, clinical trial","volume":"1","author":"Rasmussen","year":"2014","journal-title":"Lancet HIV"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005237"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1023\/A:1011091300321"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1086\/338123"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1172\/JCI97555"},{"key":"B22","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.01842","article-title":"Have cells harboring the HIV reservoir been immunoedited?","volume":"10","author":"Huang","year":"2019","journal-title":"Front Immunol"},{"issue":"18","key":"B23","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.122795","article-title":"Long-term remission despite clonal expansion of replication-competent HIV-1 isolates","volume":"3","author":"Veenhuis","year":"2018","journal-title":"JCI Insight"},{"issue":"2","key":"B24","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/cyto.a.20363","article-title":"Differential susceptibility of leukocyte subsets to cytotoxic T cell killing: implications for HIV immunopathogenesis","volume":"71","author":"Liu","year":"2007","journal-title":"Cytometry A"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3182a1bc81"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20011836"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-07-441832"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0085-3"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.201398198"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2017.04.002"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genet.33.1.29"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1126\/science.7533326"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2308"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5381.1322"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81683-9"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-2006"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.2.529"},{"issue":"12","key":"B38","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19123950","article-title":"Bcl-2 inhibition to overcome resistance to chemo- and immunotherapy","volume":"19","author":"Garc\u00eda-Aranda","year":"2018","journal-title":"Int J Mol Sci"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3048"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.34.7898"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1972"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1038\/44385"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2010.10.002"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007619"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-0898-8"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.03179-15"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.09.020"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-07-168393"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2015.0106"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2014.207"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2015.12.007"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1038\/nature05115"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20081398"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061496"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1038\/nm1482"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0b013e3283454c39"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1604958"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1038\/nature23477"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2297"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2007.07.001"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1172\/JCI28281"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.18.11671"},{"issue":"13","key":"B63","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00037-18","article-title":"HIV protease-generated Casp8p41, when bound and inactivated by Bcl2, is degraded by the proteasome","volume":"92","author":"Natesampillai","year":"2018","journal-title":"J Virol"},{"issue":"11","key":"B64","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00012-17","article-title":"Maintenance of the HIV reservoir is antagonized by selective BCL2 inhibition","volume":"91","author":"Cummins","year":"2017","journal-title":"J Virol"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000026"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1126\/science.271.5255.1582"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1720665115"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.04.004"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2017.03.008"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1609057113"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-05-785683"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1713976"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-99-113134"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-08541-2"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts635"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2450"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1621"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt703"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0055943"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003398"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/132374\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T13:32:53Z","timestamp":1691069573000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/132374"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,13]]},"references-count":81,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2020,3,23]]},"published-print":{"date-parts":[[2020,3,23]]}},"alternative-id":["10.1172\/JCI132374"],"URL":"https:\/\/doi.org\/10.1172\/jci132374","relation":{},"ISSN":["0021-9738","1558-8238"],"issn-type":[{"value":"0021-9738","type":"print"},{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,13]]}}}