{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:27:50Z","timestamp":1791476870885,"version":"4.3.4"},"reference-count":47,"publisher":"American Society for Clinical Investigation","issue":"2","funder":[{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"crossref","award":["U19 Al109646-04"],"award-info":[{"award-number":["U19 Al109646-04"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Martin Delaney Collaboration HIV Cure Research","award":["2528109374"],"award-info":[{"award-number":["2528109374"]}]},{"DOI":"10.13039\/100001340","name":"WW Smith Charitable Trust","doi-asserted-by":"crossref","award":["6743101374"],"award-info":[{"award-number":["6743101374"]}],"id":[{"id":"10.13039\/100001340","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,6]]},"DOI":"10.1172\/jci132779","type":"journal-article","created":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T17:59:47Z","timestamp":1573149587000},"page":"827-837","source":"Crossref","is-referenced-by-count":44,"title":["In vivo delivery of synthetic DNA\u2013encoded antibodies induces broad HIV-1\u2013neutralizing activity"],"prefix":"10.1172","volume":"130","author":[{"given":"Megan C.","family":"Wise","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7690-7029","authenticated-orcid":false,"given":"Ziyang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar","family":"Tello-Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Beck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aspen","family":"Trautz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2104-9984","authenticated-orcid":false,"given":"Ami","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah T.C.","family":"Elliott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7165-4544","authenticated-orcid":false,"given":"Neethu","family":"Chokkalingam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4388-8498","authenticated-orcid":false,"given":"Melissa G.","family":"Kerkau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6807-2065","authenticated-orcid":false,"given":"Kar","family":"Muthumani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul D.","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5326-4937","authenticated-orcid":false,"given":"Stephany J.","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor R.F.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janess","family":"Mendoza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate E.","family":"Broderick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0856-6319","authenticated-orcid":false,"given":"David C.","family":"Montefiori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7747-3349","authenticated-orcid":false,"given":"Guido","family":"Ferrari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0527-3804","authenticated-orcid":false,"given":"Daniel W.","family":"Kulp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent M.","family":"Humeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Weiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2020,1,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60164-1"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12484"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12511"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0001-2"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0186-4"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0531-2"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0000000000000475"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1608243"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/nature18929"},{"key":"B10","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/8724549","article-title":"Antibody-mediated therapy against HIV\/AIDS: Where are we standing now?","volume":"2018","author":"Awi","year":"2018","journal-title":"J Pathog"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1967"},{"issue":"7379","key":"B12","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nature10660","article-title":"Antibody-based protection against HIV infection by vectored immunoprophylaxis","volume":"481","author":"Balazs","year":"2011","journal-title":"Nature"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00908-15"},{"key":"B14","doi-asserted-by":"crossref","DOI":"10.1038\/mtm.2016.68","article-title":"Promise and problems associated with the use of recombinant AAV for the delivery of anti-HIV antibodies","volume":"3","author":"Fuchs","year":"2016","journal-title":"Mol Ther Methods Clin Dev"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(19)30003-7"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.10.062"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00576-7"},{"issue":"18","key":"B18","first-page":"s41541-017-0020-x","article-title":"DmAb inoculation of synthetic cross reactive antibodies protects against lethal influenza A and B infections","volume":"2","author":"Elliott","year":"2017","journal-title":"NPJ Vaccines"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiw111"},{"key":"B20","doi-asserted-by":"crossref","DOI":"10.1038\/srep12616","article-title":"Protection against dengue disease by synthetic nucleic acid antibody prophylaxis\/immunotherapy","volume":"5","author":"Flingai","year":"2015","journal-title":"Sci Rep"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2019.03.005"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02853-13"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2011.03.008"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.10.027"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1126\/science.1207227"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.3291"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/nature10373"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aal1321"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2019.01.004"},{"key":"B30","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/1298473","article-title":"Immunogenicity of biotherapeutics: causes and association with posttranslational modifications","volume":"2016","author":"Kuriakose","year":"2016","journal-title":"J Immunol Res"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2015.191"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.2174\/1574884712666170809124728"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.16.178061"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007395"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aao4235"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1214785109"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20132494"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/nature12744"},{"key":"B39","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14630","article-title":"Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge","volume":"8","author":"Pardi","year":"2017","journal-title":"Nat Commun"},{"issue":"7","key":"B40","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01925-17","article-title":"Therapeutic efficacy of vectored PGT121 gene delivery in HIV-1-infected humanized mice","volume":"92","author":"Badamchi-Zadeh","year":"2018","journal-title":"J Virol"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2018.10.016"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.2165\/00063030-200923020-00003"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12506"},{"key":"B44","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jim.2013.11.022","article-title":"Optimization and validation of the TZM-bl assay for standardized assessments of neutralizing antibodies against HIV-1","volume":"409","author":"Sarzotti-Kelsoe","year":"2014","journal-title":"J Immunol Methods"},{"issue":"2","key":"B45","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1128\/JVI.59.2.284-291.1986","article-title":"Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone","volume":"59","author":"Adachi","year":"1986","journal-title":"J Virol"},{"issue":"8","key":"B46","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/cyto.a.21084","article-title":"High-throughput quantitative analysis of HIV-1 and SIV-specific ADCC-mediating antibody responses","volume":"79","author":"Pollara","year":"2011","journal-title":"Cytometry A"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00156-14"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/132779\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T17:33:05Z","timestamp":1691083985000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/132779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,6]]},"references-count":47,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,12,17]]},"published-print":{"date-parts":[[2019,12,17]]}},"alternative-id":["10.1172\/JCI132779"],"URL":"https:\/\/doi.org\/10.1172\/jci132779","relation":{},"ISSN":["0021-9738","1558-8238"],"issn-type":[{"value":"0021-9738","type":"print"},{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,6]]}}}