{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:44:15Z","timestamp":1791863055931,"version":"4.3.4"},"reference-count":59,"publisher":"American Society for Clinical Investigation","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,4]]},"DOI":"10.1172\/jci133181","type":"journal-article","created":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T22:01:00Z","timestamp":1596492060000},"page":"4663-4678","source":"Crossref","is-referenced-by-count":34,"title":["MICAL1 constrains cardiac stress responses and protects against disease by oxidizing CaMKII"],"prefix":"10.1172","volume":"130","author":[{"given":"Klitos","family":"Konstantinidis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0825-6580","authenticated-orcid":false,"given":"Vassilios J.","family":"Bezzerides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lo","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly M.","family":"Isbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7927-1636","authenticated-orcid":false,"given":"An-Chi","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuejin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meera C.","family":"Viswanathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian D.","family":"Blum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M.","family":"Granger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Heims-Waldron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7753-089X","authenticated-orcid":false,"given":"Elizabeth D.","family":"Luczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin R.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fujian","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel H.","family":"Gratz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Manta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinchuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex L.","family":"Kolodkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vadim N.","family":"Gladyshev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9957-7306","authenticated-orcid":false,"given":"Thomas J.","family":"Hund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William T.","family":"Pu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark N.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1104-4407","authenticated-orcid":false,"given":"Anthony","family":"Cammarato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9032-7549","authenticated-orcid":false,"given":"Mario A.","family":"Bianchet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeline A.","family":"Shea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7908-7206","authenticated-orcid":false,"given":"Rodney L.","family":"Levine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark E.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2020,8,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0806422106"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.243956"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0813013106"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1172\/JCI38022"},{"issue":"pt 3","key":"B5","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1042\/bj20020228","article-title":"Structure-function of the multifunctional Ca2+\/calmodulin-dependent protein kinase II","volume":"364","author":"Hudmon","year":"2002","journal-title":"Biochem J"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1126\/science.1211956"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/nature08724"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2013.06.019"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2871"},{"key":"B10","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2013.369","article-title":"CaMKII inhibition rectifies arrhythmic phenotype in a patient-specific model of catecholaminergic polymorphic ventricular tachycardia","volume":"4","author":"Di Pasquale","year":"2013","journal-title":"Cell Death Dis"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2010.10.001"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.038514"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.039711"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.02.048"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504838102"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504997102"},{"key":"B17","doi-asserted-by":"crossref","DOI":"10.1038\/srep22176","article-title":"Modulation of MICAL monooxygenase activity by its calponin homology domain: structural and mechanistic insights","volume":"6","author":"Alqassim","year":"2016","journal-title":"Sci Rep"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-17943-5"},{"issue":"1\u20132","key":"B19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.abb.2011.08.004","article-title":"Kinetic and spectroscopic characterization of the putative monooxygenase domain of human MICAL-1","volume":"515","author":"Zucchini","year":"2011","journal-title":"Arch Biochem Biophys"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2017.02.010"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2506"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1002\/prot.22317"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.24.9497"},{"key":"B24","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2014.00005","article-title":"The role of CaMKII regulation of phospholamban activity in heart disease","volume":"5","author":"Mattiazzi","year":"2014","journal-title":"Front Pharmacol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/nm1215"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1172\/JCI65268"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1172\/JCI57833"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2019.02.001"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3390"},{"key":"B30","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14528","article-title":"Oxidation of F-actin controls the terminal steps of cytokinesis","volume":"8","author":"Fr\u00e9mont","year":"2017","journal-title":"Nat Commun"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5348.227"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1021\/bi00440a030"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.110.961771"},{"issue":"2","key":"B34","first-page":"74","article-title":"Modern concepts concerning the origin of the heartbeat","volume":"28","author":"Monfredi","year":"2013","journal-title":"Physiology (Bethesda)"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3680-07.2007"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1101\/gad.237511.114"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1038\/nature20151"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-018-0688-8"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.310230"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.08.070"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.226845"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1126\/science.8235594"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.982298"},{"issue":"3 pt 2","key":"B44","first-page":"H982","article-title":"Ca-dependent facilitation of cardiac Ca current is due to Ca-calmodulin-dependent protein kinase","volume":"267","author":"Yuan","year":"1994","journal-title":"Am J Physiol"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1172\/JCI26620"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1038\/nature06617"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5352.870"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1126\/science.256.5060.1199"},{"issue":"10","key":"B49","doi-asserted-by":"crossref","first-page":"7163","DOI":"10.1016\/S0021-9258(18)53160-4","article-title":"Inactivation of Ca2+\/calmodulin-dependent protein kinase II by basal autophosphorylation","volume":"268","author":"Colbran","year":"1993","journal-title":"J Biol Chem"},{"issue":"24","key":"B50","doi-asserted-by":"crossref","first-page":"17216","DOI":"10.1016\/S0021-9258(18)41915-1","article-title":"Inhibitory autophosphorylation of multifunctional Ca2+\/calmodulin-dependent protein kinase analyzed by site-directed mutagenesis","volume":"267","author":"Hanson","year":"1992","journal-title":"J Biol Chem"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00786-4"},{"issue":"pt B","key":"B52","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.yjmcc.2015.10.014","article-title":"Oxidant stress promotes disease by activating CaMKII","volume":"89","author":"Anderson","year":"2015","journal-title":"J Mol Cell Cardiol"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25167"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2017.06.007"},{"key":"B55","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms5317","article-title":"The intracellular redox protein MICAL-1 regulates the development of hippocampal mossy fibre connections","volume":"5","author":"Van Battum","year":"2014","journal-title":"Nat Commun"},{"key":"B56"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2623"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1101275108"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2016.152"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/133181\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T17:33:15Z","timestamp":1691083995000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/133181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,4]]},"references-count":59,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,7,27]]},"published-print":{"date-parts":[[2020,7,27]]}},"alternative-id":["10.1172\/JCI133181"],"URL":"https:\/\/doi.org\/10.1172\/jci133181","relation":{},"ISSN":["0021-9738","1558-8238"],"issn-type":[{"value":"0021-9738","type":"print"},{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,4]]}}}