{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:58:35Z","timestamp":1791435515388,"version":"4.3.3"},"reference-count":79,"publisher":"American Society for Clinical Investigation","issue":"10","funder":[{"name":"European Research Council","award":["TRAIN-OLD nr. 833247"],"award-info":[{"award-number":["TRAIN-OLD nr. 833247"]}]},{"DOI":"10.13039\/501100001732","name":"Danish National Research Foundation","doi-asserted-by":"crossref","award":["DNRF108"],"award-info":[{"award-number":["DNRF108"]}],"id":[{"id":"10.13039\/501100001732","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Netherlands Organization for Scientific Research","award":["Spinoza"],"award-info":[{"award-number":["Spinoza"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,21]]},"DOI":"10.1172\/jci133934","type":"journal-article","created":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T12:02:46Z","timestamp":1595332966000},"page":"5603-5617","source":"Crossref","is-referenced-by-count":149,"title":["Circadian rhythm influences induction of trained immunity by BCG vaccination"],"prefix":"10.1172","volume":"130","author":[{"given":"L. Charlotte J.","family":"de Bree","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera P.","family":"Mourits","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5783-9013","authenticated-orcid":false,"given":"Valerie A.C.M.","family":"Koeken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone J.C.F.M.","family":"Moorlag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robine","family":"Janssen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5811-8875","authenticated-orcid":false,"given":"Lukas","family":"Folkman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3373-9939","authenticated-orcid":false,"given":"Daniele","family":"Barreca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1374-0329","authenticated-orcid":false,"given":"Thomas","family":"Krausgruber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0052-5731","authenticated-orcid":false,"given":"Victoria","family":"Fife-Gernedl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Novakovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6649-7190","authenticated-orcid":false,"given":"Rob J.W.","family":"Arts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7015-3916","authenticated-orcid":false,"given":"Helga","family":"Dijkstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4185-1955","authenticated-orcid":false,"given":"Heidi","family":"Lemmers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6091-3088","authenticated-orcid":false,"given":"Christoph","family":"Bock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6166-9830","authenticated-orcid":false,"given":"Leo A.B.","family":"Joosten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinout","family":"van Crevel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6102-3810","authenticated-orcid":false,"given":"Christine S.","family":"Benn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihai G.","family":"Netea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2020,9,21]]},"reference":[{"key":"B1","unstructured":"WHO. BCG immunization coverage estimates by WHO region. 2018. Global Health Observatory data repository. https:\/\/apps.who.int\/gho\/data\/view.main.81500?lang=en Updated August 26, 2019. Accessed August 4, 2020"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68507-3"},{"issue":"9","key":"B3","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1001\/jama.1994.03510330076038","article-title":"Efficacy of BCG vaccine in the prevention of tuberculosis. Meta-analysis of the published literature","volume":"271","author":"Colditz","year":"1994","journal-title":"JAMA"},{"key":"B4","doi-asserted-by":"crossref","first-page":"S64","DOI":"10.1086\/314072","article-title":"Preventing tuberculosis with bacillus Calmette-Gu\u00e9rin vaccine: a meta-analysis of the literature","volume":"31 suppl 3","author":"Brewer","year":"2000","journal-title":"Clin Infect Dis"},{"key":"B5","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.13588.1","article-title":"Progress and challenges in TB vaccine development","volume":"7","author":"Voss","year":"2018","journal-title":"F1000Res"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1093\/trstmh\/tru168"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir240"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3182458289"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix525"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix612"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2013.04.004"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2018.06.002"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiy544"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3178"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2014.10.005"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1202870109"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.11.011"},{"issue":"1\u20132","key":"B18","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.cell.2017.12.031","article-title":"BCG educates hematopoietic stem cells to generate protective innate immunity against tuberculosis","volume":"172","author":"Kaufmann","year":"2018","journal-title":"Cell"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2020.05.014"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2017.12.010"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1126\/science.1250684"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00349-16"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-08659-3"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-03-0779"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.01.002"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0906361106"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.02.002"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/nri3386"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1177\/0748730415577723"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2016.04.032"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8986.2008.00662.x"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2017.05.074"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.149252"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-019-0025-4"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0135652"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-017-3097-2"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2016.10.006"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1126\/science.aah4966"},{"issue":"4","key":"B39","first-page":"203","article-title":"Nycthemeral variations on LPS- and BCG-induced PMN migration in normal mice","volume":"13","author":"Bureau","year":"1991","journal-title":"Int J Tissue React"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3109\/07420528609083156"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1007\/s000110050717"},{"issue":"3","key":"B42","first-page":"187","article-title":"Circadian influence on the immunization of mice with live bacillus Calmette-Gu\u00e9rin (BCG) and subsequent challenge with Ehrlich ascites carcinoma","volume":"6","author":"Tsai","year":"1979","journal-title":"Chronobiologia"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-11297-8"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.08.004"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2017.07.007"},{"issue":"3","key":"B46","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1002\/gcc.20739","article-title":"The transcription factor SP1 regulates centriole function and chromosomal stability through a functional interaction with the mammalian target of rapamycin\/raptor complex","volume":"49","author":"Astrinidis","year":"2010","journal-title":"Genes Chromosomes Cancer"},{"key":"B47","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2014.00023","article-title":"In silico discovery of novel transcription factors regulated by mTOR-pathway activities","volume":"2","author":"Jablonska","year":"2014","journal-title":"Front Cell Dev Biol"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1000718"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01734.x"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-019-0704-0"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1601895113"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1177\/1753425916681075"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-03-1281"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.07.015"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1038\/nature06685"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-08-867648"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.04.008"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-12-380113"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1800431115"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2010.04.005"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1714021"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2688"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3646"},{"key":"B64","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2105-15-182","article-title":"Skewer: a fast and accurate adapter trimmer for next-generation sequencing paired-end reads","volume":"15","author":"Jiang","year":"2014","journal-title":"BMC Bioinformatics"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1923"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv098"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2008-9-9-r137"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1038\/nature11247"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky955"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-02464-y"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2014-15-2-r29"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2010-11-3-r25"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv612"},{"issue":"Database issue","key":"B74","doi-asserted-by":"crossref","first-page":"D1117","DOI":"10.1093\/nar\/gku895","article-title":"CODEX: a next-generation sequencing experiment database for the haematopoietic and embryonic stem cell communities","volume":"43","author":"S\u00e1nchez-Castillo","year":"2015","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"B75","first-page":"D87","article-title":"JASPAR 2020: update of the open-access database of transcription factor binding profiles","volume":"48","author":"Fornes","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw377"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw1092"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.10.018"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4139"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/133934\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T09:33:42Z","timestamp":1723282422000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/133934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,21]]},"references-count":79,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2020,10,1]]},"published-print":{"date-parts":[[2020,10,1]]}},"alternative-id":["10.1172\/JCI133934"],"URL":"https:\/\/doi.org\/10.1172\/jci133934","relation":{},"ISSN":["0021-9738","1558-8238"],"issn-type":[{"value":"0021-9738","type":"print"},{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,21]]}}}