{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T19:52:17Z","timestamp":1793735537675,"version":"4.6.1"},"reference-count":99,"publisher":"American Society for Clinical Investigation","issue":"1","funder":[{"name":"National Institutes of Health (NIH) Clinical and Translational Science Award (CTSA) program","award":["UL1TR001866"],"award-info":[{"award-number":["UL1TR001866"]}]},{"name":"NIH","award":["R01NS072381,R01AI088364"],"award-info":[{"award-number":["R01NS072381,R01AI088364"]}]},{"DOI":"10.13039\/501100001665","name":"French National Research Agency","doi-asserted-by":"crossref","award":["ANR-10-IAHU-01"],"award-info":[{"award-number":["ANR-10-IAHU-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Integrative Biology of Emerging Infectious Diseases Laboratoire d\u2019Excellence","award":["ANR-10-LABX-62-IBEID,ANR-14-CE14-0008-01,ANR-18-CE15-0020-02"],"award-info":[{"award-number":["ANR-10-LABX-62-IBEID,ANR-14-CE14-0008-01,ANR-18-CE15-0020-02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,4]]},"DOI":"10.1172\/jci134529","type":"journal-article","created":{"date-parts":[[2021,1,3]],"date-time":"2021-01-03T14:02:30Z","timestamp":1609682550000},"source":"Crossref","is-referenced-by-count":110,"title":["TLR3 controls constitutive IFN-\u03b2 antiviral immunity in human fibroblasts and cortical neurons"],"prefix":"10.1172","volume":"131","author":[{"given":"Daxing","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4623-852X","authenticated-orcid":false,"given":"Michael J.","family":"Ciancanelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6129-567X","authenticated-orcid":false,"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6496-881X","authenticated-orcid":false,"given":"Oliver","family":"Harschnitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6534-0984","authenticated-orcid":false,"given":"Vincent","family":"Bondet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Hasek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5847-4888","authenticated-orcid":false,"given":"Jie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1022-1259","authenticated-orcid":false,"given":"Xin","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuval","family":"Itan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7209-6257","authenticated-orcid":false,"given":"Aur\u00e9lie","family":"Cobat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3519-0727","authenticated-orcid":false,"given":"Vanessa","family":"Sancho-Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetta","family":"Bigio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6648-8684","authenticated-orcid":false,"given":"Lazaro","family":"Lorenzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Ciceri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"McAlpine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4530-7239","authenticated-orcid":false,"given":"Esperanza","family":"Anguiano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Jouanguy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Chaussabel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Meyts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8791-3165","authenticated-orcid":false,"given":"Michael S.","family":"Diamond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7016-6493","authenticated-orcid":false,"given":"Laurent","family":"Abel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun","family":"Hur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9644-8472","authenticated-orcid":false,"given":"Gregory A.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Notarangelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8875-2308","authenticated-orcid":false,"given":"Darragh","family":"Duffy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0741-7987","authenticated-orcid":false,"given":"Lorenz","family":"Studer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7782-4169","authenticated-orcid":false,"given":"Jean-Laurent","family":"Casanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen-Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2021,1,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/35099560"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-07-019307"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1863"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.08.007"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2007.07.007"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e3282f151d2"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2012.11.001"},{"key":"B8","unstructured":"Grinde B. Herpesviruses: latency and reactivation - viral strategies and host response. J Oral Microbiol. [Published online Oct 25, 2013]"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1126\/science.1128346"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1126\/science.1139522"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.04.059"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/ng1097"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20101568"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20111316"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.08.014"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1172\/JCI59259"},{"key":"B17","doi-asserted-by":"crossref","unstructured":"Bastard P, et al. Herpes simplex encephalitis in a patient with a distinctive form of inherited IFNAR1 deficiency [published ahead of print September 22, 2020]. J Clin Invest. https:\/\/doi.org\/10.1172\/JCI139980","DOI":"10.1172\/JCI139980"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200612056"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/nature06726"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/ni1297"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.04.011"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2015.46"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2009.0068"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000999"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/nature11583"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1809853115"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-092412-155654"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20080091"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.80.10.5059-5064.2006"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1126\/science.1244040"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/nature04734"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/35013114"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.04.010"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1038\/ni1243"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/nature04193"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.08.012"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2005.08.014"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(85)90349-6"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)00120-9"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.10.033"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.8.5078"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0603082103"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2010.07.018"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.211"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-3653"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)00064-9"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)00053-4"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1126\/science.288.5475.2357"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1126\/science.1231143"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20161451"},{"key":"B51"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(98)01514-2"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2004.01.033"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.9.6301"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0020053"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.1.483"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0400525101"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.3.1937"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0810372105"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004127"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1038\/nature12862"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20161759"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1704259114"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M310175200"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20081370"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2861"},{"issue":"12","key":"B67","first-page":"6929","article-title":"The microtubule regulator stathmin is an endogenous protein agonist for TLR3","volume":"184","author":"Amor","year":"2018","journal-title":"J Immunol"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1005807107"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-050715-104506"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20181621"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.04.025"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix166"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.05.016"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1126\/science.abd4570"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1126\/science.abd4585"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20180628"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa1578"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aac4227"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20182295"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2018.06.004"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.2.602"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.61.5.567"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2004.11.023"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-1702(01)00251-9"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.71.1.371-377.1997"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00935-08"},{"key":"B87"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-012-1870-y"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw354"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-018-0785-7"},{"issue":"1","key":"B91","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2012","journal-title":"Bioinformatics"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts356"},{"issue":"7","key":"B93","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2013","journal-title":"Bioinformatics"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1101\/gr.135350.111"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"issue":"1","key":"B96","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2009","journal-title":"Bioinformatics"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw313"},{"issue":"4","key":"B98","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1093\/bioinformatics\/btt703","article-title":"Causal analysis approaches in Ingenuity Pathway Analysis","volume":"30","author":"Kr\u00e4mer","year":"2013","journal-title":"Bioinformatics"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1038\/nature17664"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/134529\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T13:34:03Z","timestamp":1691069643000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/134529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,4]]},"references-count":99,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,1,4]]},"published-print":{"date-parts":[[2021,1,4]]}},"alternative-id":["10.1172\/JCI134529"],"URL":"https:\/\/doi.org\/10.1172\/jci134529","relation":{},"ISSN":["0021-9738","1558-8238"],"issn-type":[{"value":"0021-9738","type":"print"},{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,4]]},"article-number":"e134529"}}