{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:33:57Z","timestamp":1792787637909,"version":"4.5.0"},"reference-count":59,"publisher":"American Society for Clinical Investigation","issue":"11","funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"crossref","award":["HHSN261200800001E,75N91019D00024,l3XS110"],"award-info":[{"award-number":["HHSN261200800001E,75N91019D00024,l3XS110"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"crossref","award":["Howard Hughes Medical Research Fellows Program"],"award-info":[{"award-number":["Howard Hughes Medical Research Fellows Program"]}],"id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"crossref","award":["OPP1115715"],"award-info":[{"award-number":["OPP1115715"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000048","name":"The American Cancer Society","doi-asserted-by":"crossref","award":["Unknown"],"award-info":[{"award-number":["Unknown"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006084","name":"Office of AIDS Research","doi-asserted-by":"crossref","award":["Unknown"],"award-info":[{"award-number":["Unknown"]}],"id":[{"id":"10.13039\/100006084","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000060","name":"NIAID","doi-asserted-by":"crossref","award":["UM1AI126603"],"award-info":[{"award-number":["UM1AI126603"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100011124","name":"University of Rochester Center for AIDS Research","doi-asserted-by":"crossref","award":["P30AI078498"],"award-info":[{"award-number":["P30AI078498"]}],"id":[{"id":"10.13039\/100011124","id-type":"DOI","asserted-by":"crossref"}]},{"name":"University of Rochester HIV\/AIDS Clinical Trials Unit","award":["UM1 AI069511-08"],"award-info":[{"award-number":["UM1 AI069511-08"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,5]]},"DOI":"10.1172\/jci138099","type":"journal-article","created":{"date-parts":[[2020,10,4]],"date-time":"2020-10-04T18:00:51Z","timestamp":1601834451000},"page":"5847-5857","source":"Crossref","is-referenced-by-count":156,"title":["HIV-1 viremia not suppressible by antiretroviral therapy can originate from large T cell clones producing infectious virus"],"prefix":"10.1172","volume":"130","author":[{"given":"Elias K.","family":"Halvas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin W.","family":"Joseph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah D.","family":"Brandt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele D.","family":"Sobolewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana L.","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8547-8107","authenticated-orcid":false,"given":"Camille","family":"Tumiotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John K.","family":"Bui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3601-4837","authenticated-orcid":false,"given":"Joshua C.","family":"Cyktor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2381-1151","authenticated-orcid":false,"given":"Brandon F.","family":"Keele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gene D.","family":"Morse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6899-1459","authenticated-orcid":false,"given":"Michael J.","family":"Bale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary F.","family":"Kearney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3856-762X","authenticated-orcid":false,"given":"John M.","family":"Coffin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8377-425X","authenticated-orcid":false,"given":"Jason W.","family":"Rausch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6432-1300","authenticated-orcid":false,"given":"Xiaolin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen H.","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Mellors","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2020,10,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199803263381301"},{"issue":"14","key":"B2","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1126\/science.278.5341.1295","article-title":"Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy","volume":"278","author":"Finzi","year":"1997","journal-title":"Science"},{"issue":"14","key":"B3","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1126\/science.278.5341.1291","article-title":"Recovery of replication-competent HIV despite prolonged suppression of plasma viremia","volume":"278","author":"Wong","year":"1997","journal-title":"Science"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/nm880"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.09.020"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4156"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1617789113"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006230"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20170193"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1522675113"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1172\/JCI124291"},{"issue":"3","key":"B12","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1128\/JVI.02139-15","article-title":"Origin of rebound plasma HIV includes cells with identical proviruses that are transcriptionally active before stopping of antiretroviral therapy","volume":"90","author":"Kearney","year":"2015","journal-title":"J Virol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1617961114"},{"key":"B14","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2019.02204","article-title":"HIV infected T cells can proliferate in vivo without inducing expression of the integrated provirus","volume":"10","author":"Musick","year":"2019","journal-title":"Front Microbiol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1172\/JCI126714"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.10.4531-4536.2003"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02060-14"},{"issue":"3","key":"B18","doi-asserted-by":"crossref","DOI":"10.1128\/JCM.01714-18","article-title":"A simpler and more sensitive single-copy HIV-1 RNA assay for quantification of persistent HIV-1 viremia in individuals on suppressive antiretroviral therapy","volume":"57","author":"Tosiano","year":"2019","journal-title":"J Clin Microbiol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0903107106"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1086\/650749"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000321"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02904-15"},{"key":"B23","first-page":"3","article-title":"Enhanced culture assay for detection and quantitation of latently infected, resting CD4+ T-cells carrying replication-competent virus in HIV-1-infected individuals","volume":"304","author":"Siliciano","year":"2005","journal-title":"Methods Mol Biol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofv123"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1046\/j.0902-4441.2003.00199.x"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0225512"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12345"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1RU0814-382"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01420-14"},{"key":"B30","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/S0015-0282(03)00778-7","article-title":"Fraction of the peripheral blood concentration of CD56+\/CD16-\/CD3- cells in total natural killer cells as an indication of fertility and infertility","volume":"80 Suppl 2","author":"Michou","year":"2003","journal-title":"Fertil Steril"},{"issue":"6","key":"B31","first-page":"1285","article-title":"CD69 expression on peripheral CD4+ T cells parallels disease activity and is reduced by mycophenolate mofetil therapy in uveitis","volume":"42","author":"Kilmartin","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"B32","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.01800","article-title":"Changes in the NK cell repertoire related to initiation of TB treatment and onset of immune reconstitution inflammatory syndrome in TB\/HIV co-infected patients in Rio de Janeiro, Brazil-ANRS 12274","volume":"10","author":"Giacoia-Gripp","year":"2019","journal-title":"Front Immunol"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006285"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1126\/science.1254194"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.1.406-413.2005"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20090378"},{"key":"B37","unstructured":"Joseph KW, et al. High-throughput sequencing of integrated HIV-1 reveals novel proviral structures. Abstract presented at: 9th International Workshop on HIV Persistence during Therapy; December 10\u201313, 2019; Miami, Florida, USA. https:\/\/www.hiv-persistence.com\/wp-content\/uploads\/2019\/12\/Programme-final-A5-WORKSHOP-Miami-2019-USA-10-12-1.pdf Accessed August 24, 2020"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1086\/503914"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1007\/s40268-017-0205-9"},{"key":"B40","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jchromb.2013.11.054","article-title":"A sensitive HPLC-MS\/MS method for the determination of dolutegravir in human plasma","volume":"945\u2013946","author":"Bennetto-Hood","year":"2014","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1371"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1126\/science.1256304"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0808028105"},{"issue":"6","key":"B44","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1101\/gr.229102","article-title":"The human genome browser at UCSC","volume":"12","author":"Kent","year":"2002","journal-title":"Genome Res"},{"issue":"4","key":"B45","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1101\/gr.229202","article-title":"BLAT--the BLAST-like alignment tool","volume":"12","author":"Kent","year":"2002","journal-title":"Genome Res"},{"key":"B46"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.15.9625-9634.2005"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00591-06"},{"key":"B49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/604261","article-title":"Protease-mediated maturation of HIV: inhibitors of protease and the maturation process","volume":"604261","author":"Adamson","year":"2012","journal-title":"Mol Biol Int"},{"issue":"157","key":"B50","first-page":"1","article-title":"Prolonged persistence of a novel replication-defective HIV-1 variant in plasma of a patient on suppressive therapy","volume":"13","author":"Rassler","year":"2016","journal-title":"Virol J"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00864-4"},{"issue":"3","key":"B52","doi-asserted-by":"crossref","first-page":"16725","DOI":"10.1073\/pnas.0804192105","article-title":"HIV rebounds from latently infected cells, rather than from continuing low-level replication","volume":"105","author":"Joos","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2019.08.003"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20180936"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0531-2"},{"issue":"1","key":"B56","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1128\/JVI.01231-06","article-title":"Rapid reversion of sequence polymorphisms dominates early human immunodeficiency virus type 1 evolution","volume":"81","author":"Li","year":"2006","journal-title":"J Virol"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/mst197"},{"issue":"5","key":"B58","doi-asserted-by":"crossref","first-page":"e02035","DOI":"10.1128\/JVI.02035-18","article-title":"Contrasting roles of the PD-1 signaling pathway in dendritic cell-mediated induction and regulation of HIV-1-specific effector T cell functions","volume":"93","author":"Garcia-Bates","year":"2019","journal-title":"J Virol"},{"issue":"1","key":"B59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/aid.2019.0214","article-title":"HIV Proviral Sequence Database: a new public database for near full-length HIV proviral sequences and their meta-analyses","volume":"00","author":"Shao","year":"2019","journal-title":"AIDS Res Hum Retroviruses"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/138099\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T13:35:31Z","timestamp":1691069731000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/138099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,5]]},"references-count":59,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020,11,2]]},"published-print":{"date-parts":[[2020,11,2]]}},"alternative-id":["10.1172\/JCI138099"],"URL":"https:\/\/doi.org\/10.1172\/jci138099","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.01.30.924159","asserted-by":"object"}]},"ISSN":["0021-9738","1558-8238"],"issn-type":[{"value":"0021-9738","type":"print"},{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,5]]}}}