{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:35:21Z","timestamp":1793054121853,"version":"4.5.0"},"reference-count":62,"publisher":"American Society for Clinical Investigation","issue":"12","funder":[{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["R37 HD34860 (SMM)"],"award-info":[{"award-number":["R37 HD34860 (SMM)"]}],"id":[{"id":"https:\/\/ror.org\/04byxyr05","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Institute of Health Research, United Kingdom","award":["NIHR-RP-2014-05-001"],"award-info":[{"award-number":["NIHR-RP-2014-05-001"]}],"id":[{"id":"https:\/\/ror.org\/0187kwz08","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Institute of Health Research (NIHR) Clinician Scientist Award","award":["CS-2018-18-ST2-002"],"award-info":[{"award-number":["CS-2018-18-ST2-002"]}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"crossref","award":["EP\/N014391\/1"],"award-info":[{"award-number":["EP\/N014391\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Institute of Health, United States","award":["R37 HD34860 (SMM)"],"award-info":[{"award-number":["R37 HD34860 (SMM)"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,11,16]]},"DOI":"10.1172\/jci139681","type":"journal-article","created":{"date-parts":[[2020,11,15]],"date-time":"2020-11-15T18:00:57Z","timestamp":1605463257000},"page":"6739-6753","source":"Crossref","is-referenced-by-count":94,"title":["Kisspeptin receptor agonist has therapeutic potential for female reproductive disorders"],"prefix":"10.1172","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2795-5256","authenticated-orcid":false,"given":"Ali","family":"Abbara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei Chia","family":"Eng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Phylactou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5426-2941","authenticated-orcid":false,"given":"Sophie A.","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5487-0528","authenticated-orcid":false,"given":"Charlene M.","family":"Sykes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6601-7150","authenticated-orcid":false,"given":"Chayarndorn","family":"Phumsatitpong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edouard","family":"Mills","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Modi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7599-0166","authenticated-orcid":false,"given":"Chioma","family":"Izzi-Engbeaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debbie","family":"Papadopoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0296-647X","authenticated-orcid":false,"given":"Kate","family":"Purugganan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Channa N.","family":"Jayasena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Webber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehan","family":"Salim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryn","family":"Owen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Bech","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7104-2297","authenticated-orcid":false,"given":"Alexander N.","family":"Comninos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4836-5351","authenticated-orcid":false,"given":"Craig A.","family":"McArdle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6488-7198","authenticated-orcid":false,"given":"Margaritis","family":"Voliotis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6294-7051","authenticated-orcid":false,"given":"Krasimira","family":"Tsaneva-Atanasova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Moenter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aylin","family":"Hanyaloglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waljit S.","family":"Dhillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2020,11,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1834399100"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035322"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005-0337"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3328-05.2005"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1802053115"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1210\/en.2006-1435"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/35079135"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-1468"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-1116"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1282"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-3400240"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1172\/JCI75730"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-2332"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1569"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-0406"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2010.204"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M104847200"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0089"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dev143"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b00379"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1159\/000357809"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1021\/jm0609824"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-4236"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dey256"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-00131"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2018-205579"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2018.01.005"},{"issue":"pt 8","key":"B28","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1242\/jcs.00971","article-title":"Kisspeptin-10, a KiSS-1\/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts","volume":"117","author":"Bilban","year":"2004","journal-title":"J Cell Sci"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-007-9030-8"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-1365"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.111.093492"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1159\/000083140"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-57-4-792"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dex253"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1775-08.2008"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005-0195"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1210\/er.2017-00236"},{"issue":"7","key":"B38","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1515\/CCLM.2006.160","article-title":"Establishment of detailed reference values for luteinizing hormone, follicle stimulating hormone, estradiol, and progesterone during different phases of the menstrual cycle on the Abbott ARCHITECT analyzer","volume":"44","author":"Stricker","year":"2006","journal-title":"Clin Chem Lab Med"},{"issue":"4","key":"B39","first-page":"1401","article-title":"Measurement of dimeric inhibin B throughout the human menstrual cycle","volume":"81","author":"Groome","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2015.10.014"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1159\/000299767"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1159\/000488452"},{"issue":"4","key":"B43","first-page":"311","article-title":"Kisspeptin offers a novel therapeutic target in reproduction","volume":"10","author":"Jayasena","year":"2009","journal-title":"Curr Opin Investig Drugs"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-6199-9_4"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1069"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1210\/me.2013-1165"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0041-15.2015"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1210\/en.2014-1304"},{"key":"B49","doi-asserted-by":"crossref","DOI":"10.1038\/srep26908","article-title":"A synthetic kisspeptin analog that triggers ovulation and advances puberty","volume":"6","author":"Decourt","year":"2016","journal-title":"Sci Rep"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0214424"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-0554"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1210\/en.2014-1458"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-0321"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1172\/JCI89519"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0176821"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1159\/000107770"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2009.01826.x"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-020294"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-020369"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a136283"},{"key":"B61","doi-asserted-by":"crossref","unstructured":"Ahmed TA. Pharmacokinetics of Drugs Following IV Bolus, IV Infusion, and Oral Administration. IntechOpen. https:\/\/www.intechopen.com\/books\/basic-pharmacokinetic-concepts-and-some-clinical-applications\/pharmacokinetics-of-drugs-following-iv-bolus-iv-infusion-and-oral-administration Published November 18, 2015. Accessed September 28, 2020","DOI":"10.5772\/61573"},{"key":"B62"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/139681\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T13:36:07Z","timestamp":1691069767000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/139681"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,16]]},"references-count":62,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2020,12,1]]},"published-print":{"date-parts":[[2020,12,1]]}},"alternative-id":["10.1172\/JCI139681"],"URL":"https:\/\/doi.org\/10.1172\/jci139681","relation":{},"ISSN":["0021-9738","1558-8238"],"issn-type":[{"value":"0021-9738","type":"print"},{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,16]]}}}