{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:54:24Z","timestamp":1790632464635,"version":"4.1.0"},"reference-count":39,"publisher":"American Society for Clinical Investigation","issue":"12","funder":[{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"crossref","award":["P01HL053749"],"award-info":[{"award-number":["P01HL053749"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000098","name":"NIH Clinical Center","doi-asserted-by":"crossref","award":["F31HL147482,R01GM115911"],"award-info":[{"award-number":["F31HL147482,R01GM115911"]}],"id":[{"id":"10.13039\/100000098","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,11,9]]},"DOI":"10.1172\/jci140189","type":"journal-article","created":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T12:01:29Z","timestamp":1599566489000},"page":"6677-6687","source":"Crossref","is-referenced-by-count":70,"title":["BCL11A enhancer\u2013edited hematopoietic stem cells persist in rhesus monkeys without toxicity"],"prefix":"10.1172","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6174-1609","authenticated-orcid":false,"given":"Selami","family":"Demirci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6322-8991","authenticated-orcid":false,"given":"Naoya","family":"Uchida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4092-369X","authenticated-orcid":false,"given":"Anne H.","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo","family":"Pellin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackson","family":"Gamer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan","family":"Yapundich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Drysdale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmine","family":"Bonanno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aylin C.","family":"Bonifacino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen E.","family":"Krouse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel S.","family":"Linde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"Engels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4021-3986","authenticated-orcid":false,"given":"Robert E.","family":"Donahue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6679-7812","authenticated-orcid":false,"given":"Juan J.","family":"Haro-Mora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4317-3879","authenticated-orcid":false,"given":"Alexis","family":"Leonard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Nassehi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9727-1960","authenticated-orcid":false,"given":"Kevin","family":"Luk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaina N.","family":"Porter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cicera R.","family":"Lazzarotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengdar Q.","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell J.","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3793-585X","authenticated-orcid":false,"given":"Shondra M.","family":"Pruett-Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7042-201X","authenticated-orcid":false,"given":"Scot A.","family":"Wolfe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5076-7945","authenticated-orcid":false,"given":"Daniel E.","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8535-9439","authenticated-orcid":false,"given":"John F.","family":"Tisdale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2020,11,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(19)30045-6"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-02-765891"},{"issue":"suppl 1","key":"B3","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1016\/S0268-960X(12)70011-5","article-title":"The emerging role of fetal hemoglobin induction in non-transfusion-dependent thalassemia","volume":"26","author":"Thein","year":"2012","journal-title":"Blood Rev"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/ng2108"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0711566105"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1126\/science.1165409"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/nature08243"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1126\/science.1242088"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/nature15521"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-08-736249"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3554"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0401-y"},{"key":"B13","doi-asserted-by":"crossref","DOI":"10.1038\/mtm.2014.55","article-title":"Pigtailed macaques as a model to study long-term safety of lentivirus vector-mediated gene therapy for hemoglobinopathies","volume":"1","author":"Kiem","year":"2014","journal-title":"Mol Ther Methods Clin Dev"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.05.013"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12456-3"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1002\/1097-010X(20001215)288:4<318::AID-JEZ4>3.0.CO;2-0"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1089\/104303401300057289"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-07-728691"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-02-075382"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3015"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaw3768"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-09-672337"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1980.tb08707.x"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1995.tb05199.x"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.6.2937"},{"issue":"10","key":"B26","first-page":"1156","article-title":"Hydroxyurea-induced HbF production in anemic primates: augmentation by erythropoietin, hematopoietic growth factors, and sodium butyrate","volume":"20","author":"McDonagh","year":"1992","journal-title":"Exp Hematol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2019.05.005"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2013.256"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2019.05.022"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1038\/ni925"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.08.064"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1172\/JCI87885"},{"issue":"4","key":"B33","first-page":"306","article-title":"The mathematical theory of communication. 1963","volume":"14","author":"Shannon","year":"1997","journal-title":"MD Comput"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019002350"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4278"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2008-0583"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2007.05.009"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.4192"},{"key":"B39","unstructured":"R Core Team. R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria.https:\/\/www.R-project.org\/. Accessed September 26, 2020"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/140189\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T13:36:19Z","timestamp":1691069779000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/140189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,9]]},"references-count":39,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2020,12,1]]},"published-print":{"date-parts":[[2020,12,1]]}},"alternative-id":["10.1172\/JCI140189"],"URL":"https:\/\/doi.org\/10.1172\/jci140189","relation":{},"ISSN":["0021-9738","1558-8238"],"issn-type":[{"value":"0021-9738","type":"print"},{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,9]]}}}