{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T03:08:34Z","timestamp":1788577714817,"version":"build-2803163510"},"reference-count":74,"publisher":"American Society for Clinical Investigation","issue":"14","funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["HL145397,HL142905,HL122578"],"award-info":[{"award-number":["HL145397,HL142905,HL122578"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,15]]},"DOI":"10.1172\/jci142341","type":"journal-article","created":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T18:01:02Z","timestamp":1626285662000},"source":"Crossref","is-referenced-by-count":55,"title":["Foxo1 deletion promotes the growth of new lymphatic valves"],"prefix":"10.1172","volume":"131","author":[{"given":"Joshua P.","family":"Scallan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luz A.","family":"Knauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huayan","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge A.","family":"Castorena-Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7992-9300","authenticated-orcid":false,"given":"Michael J.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3469-7681","authenticated-orcid":false,"given":"Ying","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2021,7,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI71609"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.089565"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.01.045"},{"issue":"1","key":"B4","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/cphy.c180015","article-title":"Lymphatic vessel network structure and physiology","volume":"9","author":"Breslin","year":"2018","journal-title":"Compr Physiol"},{"issue":"pt 8","key":"B5","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1113\/jphysiol.2012.250662","article-title":"Genetic removal of basal nitric oxide enhances contractile activity in isolated murine collecting lymphatic vessels","volume":"591","author":"Scallan","year":"2013","journal-title":"J Physiol"},{"issue":"pt 2","key":"B6","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1113\/jphysiol.2012.237909","article-title":"Constriction of isolated collecting lymphatic vessels in response to acute increases in downstream pressure","volume":"591","author":"Scallan","year":"2013","journal-title":"J Physiol"},{"issue":"2","key":"B7","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1177\/1358836X9800300209","article-title":"Lymphedema: classification, diagnosis and therapy","volume":"3","author":"Szuba","year":"1998","journal-title":"Vasc Med"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1002\/jso.24337"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1177\/145749690309200409"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/nm1094"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1172\/JCI89607"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2009.06.017"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2130"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/ng.923"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1172\/JCI78888"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1172\/JCI85794"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1086\/316915"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.39.7.478"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg123"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.modgep.2004.07.004"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1222722110"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2010.04.010"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2011.04.004"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12158"},{"key":"B25","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms9329","article-title":"Impaired PIEZO1 function in patients with a novel autosomal recessive congenital lymphatic dysplasia","volume":"6","author":"Lukacs","year":"2015","journal-title":"Nat Commun"},{"key":"B26","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms9085","article-title":"Novel mutations in PIEZO1 cause an autosomal recessive generalized lymphatic dysplasia with non-immune hydrops fetalis","volume":"6","author":"Fotiou","year":"2015","journal-title":"Nat Commun"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2009.01.009"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1042\/CS20050277"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060164"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1096\/fj.12-222695"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00378.2010"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00284.2011"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0052021"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3182450b2d"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3182450b47"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.07.072"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80595-4"},{"issue":"11","key":"B38","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/j.bbamcr.2011.03.013","article-title":"Interplay between FOXO, TOR, and Akt","volume":"1813","author":"Hay","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209086"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M314214200"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0400093101"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1038\/nature16498"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1172\/JCI23126"},{"issue":"2","key":"B44","doi-asserted-by":"crossref","DOI":"10.1242\/dev.181545","article-title":"FOXO1 regulates developmental lymphangiogenesis by upregulating CXCR4 in the mouse-tail dermis","volume":"147","author":"Niimi","year":"2020","journal-title":"Development"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2011.12.020"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-8712-2_7"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1172\/JCI58050"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.12.029"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-07-298562"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200901104"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1172\/JCI80454"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M600272200"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.modgep.2005.07.003"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1172\/JCI16857"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00400-3"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1038\/nature09002"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1101\/gad.16974811"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1172\/JCI79386"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1101\/gad.282400.116"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00872-13"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1038\/nri1258"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00499.2017"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.112.269316"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.112.269399"},{"issue":"Pt 8","key":"B65","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1242\/jcs.144550","article-title":"Non-muscle Mlck is required for beta-catenin- and FoxO1-dependent downregulation of Cldn5 in IL-1beta-mediated barrier dysfunction in brain endothelial cells","volume":"127","author":"Beard","year":"2014","journal-title":"J Cell Sci"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1752"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2015.10.022"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1113\/JP279472"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-12-472142"},{"key":"B70","article-title":"EphB4 forward signalling regulates lymphatic valve development","volume":"6","author":"Zhang","year":"2015","journal-title":"Nat Commun"},{"issue":"pt 1","key":"B71","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1042\/bst0310292","article-title":"Regulation of cell survival and proliferation by the FOXO (Forkhead box, class O) subfamily of Forkhead transcription factors","volume":"31","author":"Birkenkamp","year":"2003","journal-title":"Biochem Soc Trans"},{"issue":"11","key":"B72","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1016\/j.bbamcr.2011.03.010","article-title":"Akt, FoxO, and regulation of apoptosis","volume":"1813","author":"Zhang","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1126\/science.1086336"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-8712-2_15"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/142341\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T04:31:50Z","timestamp":1725424310000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/142341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,15]]},"references-count":74,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2021,7,15]]},"published-print":{"date-parts":[[2021,7,15]]}},"alternative-id":["10.1172\/JCI142341"],"URL":"https:\/\/doi.org\/10.1172\/jci142341","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,15]]},"article-number":"e142341"}}