{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:46:18Z","timestamp":1791812778333,"version":"4.3.4"},"reference-count":97,"publisher":"American Society for Clinical Investigation","issue":"23","funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche, France","doi-asserted-by":"crossref","award":["ANR-14-CE12-0007-01-DevMiCar"],"award-info":[{"award-number":["ANR-14-CE12-0007-01-DevMiCar"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"crossref","award":["academic"],"award-info":[{"award-number":["academic"]}],"id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"crossref","award":["academic"],"award-info":[{"award-number":["academic"]}],"id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007475","name":"Clermont Universit\u00e9","doi-asserted-by":"crossref","award":["academic"],"award-info":[{"award-number":["academic"]}],"id":[{"id":"10.13039\/501100007475","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the French government IDEX-ISITE initiative","award":["16-IDEX-0001 (CAP 20-25)"],"award-info":[{"award-number":["16-IDEX-0001 (CAP 20-25)"]}]},{"DOI":"10.13039\/501100004097","name":"Fondation ARC pour la Recherche sur le Cancer","doi-asserted-by":"crossref","award":["doctoral salary"],"award-info":[{"award-number":["doctoral salary"]}],"id":[{"id":"10.13039\/501100004097","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,1]]},"DOI":"10.1172\/jci146910","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T19:05:21Z","timestamp":1638299121000},"source":"Crossref","is-referenced-by-count":8,"title":["Protein kinase A drives paracrine crisis and WNT4-dependent testis tumor in Carney complex"],"prefix":"10.1172","volume":"131","author":[{"given":"Cyril","family":"Djari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Sahut-Barnola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amandine","family":"Septier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Plotton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathana\u00eblle","family":"Montanier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1220-1745","authenticated-orcid":false,"given":"Damien","family":"Dufour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9933-3478","authenticated-orcid":false,"given":"Adrien","family":"Levasseur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9127-4511","authenticated-orcid":false,"suffix":"Jr.","given":"James","family":"Wilmouth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Christophe","family":"Pointud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7959-9842","authenticated-orcid":false,"given":"Fabio R.","family":"Faucz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3872-0447","authenticated-orcid":false,"given":"Crystal","family":"Kamilaris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3479-8693","authenticated-orcid":false,"given":"Antoine-Guy","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Guillou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Swain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seppo J.","family":"Vainio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Tauveron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7648-5567","authenticated-orcid":false,"given":"Pierre","family":"Val","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Lefebvre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantine A.","family":"Stratakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Marie","family":"Lefran\u00e7ois-Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2021,12,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-2333"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.9.7903"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0b013e32801195eb"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-15-0209"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3180309e33"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e328355a279"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198507000-00007"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199711000-00002"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-0580"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb04328.x"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2016.11.004"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1111\/his.13115"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2017.04.009"},{"issue":"1","key":"B14","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1699-0463.1998.tb01325.x","article-title":"Inhibin gene expression in a large cell calcifying Sertoli cell tumour and serum inhibin and activin levels","volume":"106","author":"Toppari","year":"1998","journal-title":"APMIS"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2005.01838.x"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1210\/er.2018-00010"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/S0188-4409(99)00076-4"},{"issue":"1\u20132","key":"B18","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.mce.2006.03.026","article-title":"Genetically modified mouse models in studies of luteinising hormone action","volume":"252","author":"Huhtaniemi","year":"2006","journal-title":"Mol Cell Endocrinol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-011-9192-2"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1210\/en.2012-2179"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.20231"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1002\/gene.10100"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1242\/dev.087247"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1210\/er.2014-1101"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.4879"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1677\/joe.1.06619"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.109.078048"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.10.2125"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M105143200"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1211845109"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1007\/s12079-017-0399-1"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2010.35"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1210\/endo.140.3.6590"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.103.019471"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1210\/me.2014-1060"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1210\/me.2002-0362"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2012.01.014"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.15372"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201490434"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1038\/17068"},{"issue":"3","key":"B41","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1093\/hmg\/ddn362","article-title":"Sex-specific roles of beta-catenin in mouse gonadal development","volume":"18","author":"Liu","year":"2009","journal-title":"Hum Mol Genet"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029764"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2006.06.038"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2017.04.010"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1038\/oncsis.2017.69"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1210\/me.2012-1258"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1210\/endo.143.6.8838"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-07-2554"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12444"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.115.138016"},{"key":"B51","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/B978-0-12-407704-1.00006-3","article-title":"Regulation of blood-testis barrier (BTB) dynamics during spermatogenesis via the \u201cYin\u201d and \u201cYang\u201d effects of mammalian target of rapamycin complex 1 (mTORC1) and mTORC2","volume":"301","author":"Mok","year":"2013","journal-title":"Int Rev Cell Mol Biol"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds272"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)65285-8"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-3620"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1210\/me.2006-0060"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0272.2007.00784.x"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1210\/mend.13.6.0297"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1210\/me.2002-0032"},{"issue":"5","key":"B59","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1530\/eje.0.1380473","article-title":"Mutations of follicle-stimulating hormone and its receptor: effects on gonadal function","volume":"138","author":"Huhtaniemi","year":"1998","journal-title":"Eur J Endocrinol"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1177\/1933719112461184"},{"issue":"4","key":"B61","first-page":"1367","article-title":"An activating mutation of the follicle-stimulating hormone receptor autonomously sustains spermatogenesis in a hypophysectomized man","volume":"81","author":"Gromoll","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00763"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1210\/endo.131.6.1446630"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1993.1007"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(02)00004-7"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del158"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00293.2012"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1242\/dev.191189"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.06.055"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.105.045930"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1242\/dev.032631"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1126\/science.aas9408"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014168"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.109.079335"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025585"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a021881"},{"issue":"1\u20132","key":"B77","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.mce.2014.01.008","article-title":"Ligand-dependent stabilization of androgen receptor in a novel mouse ST38c Sertoli cell line","volume":"384","author":"Vija","year":"2014","journal-title":"Mol Cell Endocrinol"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.3390\/cells8080861"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00224"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-19-0550"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0603006103"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-0771"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1096\/fj.09-145789"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.20.9063-9072.2005"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.109.077446"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31829cdbc6"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21124272"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2016.02.011"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1734"},{"issue":"2","key":"B90","first-page":"85","article-title":"Roles for growth factors in cancer progression","volume":"25","author":"Witsch","year":"2010","journal-title":"Physiology (Bethesda)"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07858-8"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037366"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000980"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu265"},{"issue":"1","key":"B95","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms12751","article-title":"PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development","volume":"7","author":"Drelon","year":"2016","journal-title":"Nat Commun"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.20566"},{"issue":"3","key":"B97","first-page":"630","article-title":"Mutation of the Calpha subunit of PKA leads to growth retardation and sperm dysfunction","volume":"16","author":"Sk\u00e5lhegg","year":"2002","journal-title":"Mol Endocrinol"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/146910\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T17:39:41Z","timestamp":1691084381000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/146910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,1]]},"references-count":97,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2021,12,1]]},"published-print":{"date-parts":[[2021,12,1]]}},"alternative-id":["10.1172\/JCI146910"],"URL":"https:\/\/doi.org\/10.1172\/jci146910","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,1]]},"article-number":"e146910"}}