{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:13:38Z","timestamp":1791389618793,"version":"4.3.3"},"reference-count":151,"publisher":"American Society for Clinical Investigation","issue":"19","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,1]]},"DOI":"10.1172\/jci148288","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T14:20:22Z","timestamp":1633011622000},"source":"Crossref","is-referenced-by-count":97,"title":["Defining circadian disruption in neurodegenerative disorders"],"prefix":"10.1172","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1059-184X","authenticated-orcid":false,"given":"Christopher S.","family":"Colwell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2021,10,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0235-9"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-020-0333-7"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2016.04.011"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.06.019"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-0586-x"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav2642"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb8739"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1126\/science.aah4968"},{"key":"B9","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2020.105029","article-title":"Circadian alterations in patients with neurodegenerative diseases: neuropathological basis of underlying network mechanisms","volume":"144","author":"Fifel","year":"2020","journal-title":"Neurobiol Dis"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.14255"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1126\/science.1158822"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5423.2177"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1081\/CBI-100101049"},{"issue":"2","key":"B14","doi-asserted-by":"crossref","DOI":"10.3390\/clockssleep2020013","article-title":"Psychological screening for exceptional environments: laboratory circadian rhythm and sleep research","volume":"2","author":"Amira","year":"2020","journal-title":"Clocks Sleep"},{"key":"B15","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2015.00095","article-title":"Human peripheral clocks: applications for studying circadian phenotypes in physiology and pathophysiology","volume":"6","author":"Saini","year":"2015","journal-title":"Front Neurol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1177\/0748730410395732"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1508249112"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1619320114"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1800314115"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1172\/JCI120874"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-25950-0_13"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1177\/0748730403018003005"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2011.07.001"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2024500118"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2012.12.029"},{"issue":"7","key":"B26","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nrn3743","article-title":"Light as a central modulator of circadian rhythms, sleep and affect","volume":"15","author":"LeGates","year":"2014","journal-title":"Nat Rev Neurosci"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-0640-8"},{"key":"B28","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2017.00162","article-title":"Retinal ganglion cells and circadian rhythms in Alzheimer\u2019s disease, Parkinson\u2019s disease, and beyond","volume":"8","author":"La Morgia","year":"2017","journal-title":"Front Neurol"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-018-0596-z"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-26078-0"},{"key":"B31","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2019.00360","article-title":"Light-induced pupillary responses in Alzheimer\u2019s disease","volume":"10","author":"Chougule","year":"2019","journal-title":"Front Neurol"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0226197"},{"key":"B33","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2020.00780","article-title":"Chromatic pupillometry findings in Alzheimer\u2019s disease","volume":"14","author":"Romagnoli","year":"2020","journal-title":"Front Neurosci"},{"issue":"24","key":"B34","first-page":"5418","article-title":"Attenuated pupillary light responses and downregulation of opsin expression parallel decline in circadian disruption in two different mouse m-odels of Huntington\u2019s disease","volume":"25","author":"Ouk","year":"2016","journal-title":"Hum Mol Genet"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0571-18.2018"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2010.12.011"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069993"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2011.08.003"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.05.013"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1038\/srep36335"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2006.11.044"},{"issue":"1","key":"B42","first-page":"117","article-title":"Suprachiasmatic nucleus neuropeptide expression in patients with Huntington\u2019s Disease","volume":"36","author":"van Wamelen","year":"2013","journal-title":"Sleep"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.0640"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(85)91350-2"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(95)00043-E"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199901000-00004"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1177\/1533317514556876"},{"issue":"pt 6","key":"B48","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1093\/brain\/awn049","article-title":"Dorsomedial SCN neuronal subpopulations subserve different functions in human dementia","volume":"131","author":"Harper","year":"2008","journal-title":"Brain"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24432"},{"issue":"2","key":"B50","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1385\/JMN\/31:02:139","article-title":"Decreased VIP and VPAC2 receptor expression in the biological clock of the R6\/2 Huntington\u2019s disease mouse","volume":"31","author":"Fahrenkrug","year":"2007","journal-title":"J Mol Neurosci"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0147583"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2017.04.015"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.15286"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2018.03.007"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30461-7"},{"issue":"1","key":"B56","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/ejn.14358","article-title":"Interacting influences of aging and Alzheimer\u2019s disease on circadian rhythms","volume":"51","author":"Duncan","year":"2020","journal-title":"Eur J Neurosci"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-53491-0.00015-8"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80350-5"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2014.78"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2019.05.001"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-2543"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26003"},{"key":"B63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nbscr.2018.07.001","article-title":"Investigating the relationships between hypothalamic volume and measures of circadian rhythm and habitual sleep in premanifest Huntington\u2019s disease","volume":"6","author":"Bartlett","year":"2018","journal-title":"Neurobiol Sleep Circadian Rhythms"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1097\/00002826-200303000-00005"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.6239"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2013.10.016"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2020.07.043"},{"issue":"1","key":"B68","first-page":"323","article-title":"Decreased melatonin levels in postmortem cerebrospinal fluid in relation to aging, Alzheimer\u2019s disease, and apolipoprotein E-epsilon4\/4 genotype","volume":"84","author":"Liu","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(97)00510-6"},{"issue":"1\u20132","key":"B70","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0531-5565(02)00198-5","article-title":"Melatonin rhythmicity: effect of age and Alzheimer\u2019s disease","volume":"38","author":"Skene","year":"2003","journal-title":"Exp Gerontol"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2019.04.018"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6773(77)90397-2"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-01-00357.2002"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.12.012"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-13-04864.2001"},{"key":"B76","doi-asserted-by":"crossref","DOI":"10.1016\/j.autneu.2021.102775","article-title":"Autonomic dysregulation as an early pathologic feature of Huntington disease","volume":"231","author":"Schultz","year":"2021","journal-title":"Auton Neurosci"},{"issue":"5","key":"B77","doi-asserted-by":"crossref","DOI":"10.1111\/jsr.12939","article-title":"Assessing the role of nocturnal core body temperature dysregulation as a biomarker of neurodegeneration","volume":"29","author":"Raupach","year":"2020","journal-title":"J Sleep Res"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072661"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1002\/mds.1039"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(95)00059-N"},{"issue":"5","key":"B81","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1176\/appi.ajp.158.5.704","article-title":"Sundowning and circadian rhythms in Alzheimer\u2019s disease","volume":"158","author":"Volicer","year":"2001","journal-title":"Am J Psychiatry"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1097\/00019442-200505000-00004"},{"issue":"Pt 7","key":"B83","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1093\/brain\/awt132","article-title":"Longitudinal analysis of the electroencephalogram and sleep phenotype in the R6\/2 mouse model of Huntington\u2019s disease","volume":"136","author":"Fisher","year":"2013","journal-title":"Brain"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.5448"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13289"},{"issue":"1","key":"B86","first-page":"160","article-title":"Age-related changes in core body temperature and activity in triple-transgenic Alzheimer\u2019s disease (3xTgAD) mice","volume":"6","author":"Knight","year":"2013","journal-title":"Dis Model Mech"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1210\/er.2015-1080"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2010.08.006"},{"issue":"4","key":"B89","first-page":"539","article-title":"Circadian rhythms of melatonin and cortisol in manifest Huntington\u2019s disease and in acute cortical ischemic stroke","volume":"68","author":"Adamczak-Ratajczak","year":"2017","journal-title":"J Physiol Pharmacol"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(91)90007-9"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004962"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(97)80309-0"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.65"},{"issue":"Pt 5","key":"B94","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1093\/brain\/awh129","article-title":"Disrupted daily activity\/rest cycles in relation to daily cortisol rhythms of home-dwelling patients with early Alzheimer\u2019s dementia","volume":"127","author":"Hatfield","year":"2004","journal-title":"Brain"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2018.09.025"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2972"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1530\/JME-19-0153"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05-4446fje"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.10.003"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-200634"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3842-04.2005"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1694-10.2010"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1177\/0748730418790401"},{"key":"B104","doi-asserted-by":"crossref","DOI":"10.1186\/s13024-015-0007-x","article-title":"A\u03b2-induced degradation of BMAL1 and CBP leads to circadian rhythm disruption in Alzheimer\u2019s disease","volume":"10","author":"Song","year":"2015","journal-title":"Mol Neurodegener"},{"issue":"8","key":"B105","doi-asserted-by":"crossref","first-page":"850","DOI":"10.2174\/1567205014666170317113159","article-title":"Abnormal clock gene expression and locomotor activity rhythms in two month-old female APPSwe\/PS1dE9 mice","volume":"14","author":"Oyegbami","year":"2017","journal-title":"Curr Alzheimer Res"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2012.10.014"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2014.206"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.09.042"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2011.322"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2016.02.037"},{"key":"B111","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.100744","article-title":"The PDB and protein homeostasis: from chaperones to degradation and disaggregase machines","volume":"296","author":"Saibil","year":"2021","journal-title":"J Biol Chem"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1101\/gad.453808"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-12897-0"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.03.015"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1126\/science.1241224"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav2546"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aav5447"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1126\/science.1180962"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2014.02.011"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25117"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20172347"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18115-2"},{"issue":"6462","key":"B123","doi-asserted-by":"crossref","DOI":"10.1126\/science.aav3617","article-title":"Sleep-wake cycles drive daily dynamics of synaptic phosphorylation","volume":"11;366","author":"Br\u00fcning","year":"2019","journal-title":"Science"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1126\/science.aah4966"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13166"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1912109117"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2019.12.044"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30450-2"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(00)00124-X"},{"key":"B130","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2020.104832","article-title":"The wrinkling of time: aging, inflammation, oxidative stress, and the circadian clock in neurodegeneration","volume":"139","author":"Lananna","year":"2020","journal-title":"Neurobiol Dis"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4133-04.2005"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1172\/JCI70317"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3639-16.2017"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.09.015"},{"key":"B135","doi-asserted-by":"crossref","DOI":"10.1038\/srep02744","article-title":"The intrinsic microglial molecular clock controls synaptic strength via the circadian expression of cathepsin S","volume":"3","author":"Hayashi","year":"2013","journal-title":"Sci Rep"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2014.11.009"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1812405116"},{"key":"B138","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.58765","article-title":"REV-ERB\u03b1 mediates complement expression and diurnal regulation of microglial synaptic phagocytosis","volume":"9","author":"Griffin","year":"2020","journal-title":"Elife"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2013.09.002"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2019.01.002"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-021-01031-8"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsaa281"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.8078"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1802337"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-819975-6.00023-6"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-00109-w"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1002\/prp2.344"},{"key":"B148","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2017.00100","article-title":"Clock-enhancing small molecules and potential applications in chronic diseases and aging","volume":"8","author":"Gloston","year":"2017","journal-title":"Front Neurol"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20143380"},{"key":"B150","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms6759","article-title":"Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behaviour","volume":"5","author":"Banerjee","year":"2014","journal-title":"Nat Commun"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.03.039"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/148288\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T13:40:13Z","timestamp":1691070013000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/148288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,1]]},"references-count":151,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2021,10,1]]},"published-print":{"date-parts":[[2021,10,1]]}},"alternative-id":["10.1172\/JCI148288"],"URL":"https:\/\/doi.org\/10.1172\/jci148288","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,1]]},"article-number":"e148288"}}