{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T20:42:54Z","timestamp":1789677774372,"version":"4.0.1"},"reference-count":52,"publisher":"American Society for Clinical Investigation","issue":"6","license":[{"start":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T00:00:00Z","timestamp":1647302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH intramural research grant","award":["1ZIADE000695"],"award-info":[{"award-number":["1ZIADE000695"]}]},{"name":"S\u00e3o Paulo Research Foundation FAPESP","award":["2014\/23211-0,2014\/22451-7"],"award-info":[{"award-number":["2014\/23211-0,2014\/22451-7"]}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","award":["302355\/2017-0"],"award-info":[{"award-number":["302355\/2017-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Research Core of Ocular Physiopathology and Therapeutics of the University of S\u00e3o Paulo","award":["12.1.25431.01.7"],"award-info":[{"award-number":["12.1.25431.01.7"]}]},{"name":"NIH intramural research grant","award":["1ZIADE000704"],"award-info":[{"award-number":["1ZIADE000704"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,15]]},"DOI":"10.1172\/jci152780","type":"journal-article","created":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T17:00:59Z","timestamp":1643907659000},"source":"Crossref","is-referenced-by-count":29,"title":["Lysosomal exocytosis of HSP70 stimulates monocytic BMP6 expression in Sj\u00f6gren\u2019s syndrome"],"prefix":"10.1172","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9617-8927","authenticated-orcid":false,"given":"Ying-Qian","family":"Mo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9729-4006","authenticated-orcid":false,"given":"Tsutomu","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Odani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngmi","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin N.","family":"French","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5763-1036","authenticated-orcid":false,"given":"Thomas J.F.","family":"Pranzatelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drew G.","family":"Michael","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongen","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan S.","family":"Chow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Khalaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra A.","family":"Afione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyu","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiola Reis","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3887-9239","authenticated-orcid":false,"given":"Ana Carolina F.","family":"Motta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Ribeiro-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9888-7313","authenticated-orcid":false,"given":"Eduardo M.","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5633-4075","authenticated-orcid":false,"given":"Cuong Q.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Noguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5657-962X","authenticated-orcid":false,"given":"Tatsuya","family":"Atsumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4961-018X","authenticated-orcid":false,"given":"Blake M.","family":"Warner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4919-4056","authenticated-orcid":false,"given":"John A.","family":"Chiorini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2022,3,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1080\/14397595.2018.1546268"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2017.03.007"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/art.38181"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-03-143354"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/art.38123"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-59443-z"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1601992113"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1242\/dev.031534"},{"issue":"4","key":"B9","article-title":"TLR4 signaling pathway modulators as potential therapeutics in inflammation and sepsis","volume":"5","author":"Kuzmich","year":"2017","journal-title":"Vaccines (Basel)"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.4110\/in.2018.18.e27"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2009.01531.x"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1002\/art.21969"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu405"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2008.01465.x"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1002\/art.22954"},{"issue":"6","key":"B16","first-page":"1306","article-title":"Presence of antibodies against Helicobacter pylori and its heat-shock protein 60 in the serum of patients with Sj\u00f6gren\u2019s syndrome","volume":"26","author":"Aragona","year":"1999","journal-title":"J Rheumatol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1177\/1753425916633236"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3109\/03009742.2011.633099"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23420"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.10.7184"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2017.05.027"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.04.019"},{"key":"B23","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.02035","article-title":"Human monocyte subsets and phenotypes in major chronic inflammatory diseases","volume":"10","author":"Kapellos","year":"2019","journal-title":"Front Immunol"},{"key":"B24","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.01726","article-title":"Monocyte subsets: phenotypes and function in tuberculosis infection","volume":"9","author":"Sampath","year":"2018","journal-title":"Front Immunol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-219649"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-71669-5"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3109\/02656736.2013.807439"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21072576"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-6934-0_13"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.7400243"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA119.011864"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2015.08.003"},{"issue":"1","key":"B33","first-page":"110","article-title":"Oral microbial flora in Sj\u00f6gren\u2019s syndrome","volume":"26","author":"Almstahl","year":"1999","journal-title":"J Rheumatol"},{"issue":"5","key":"B34","first-page":"1007","article-title":"Microflora in oral ecosystems in primary Sj\u00f6gren\u2019s syndrome","volume":"28","author":"Almstahl","year":"2001","journal-title":"J Rheumatol"},{"issue":"6","key":"B35","first-page":"4895","article-title":"Oral microbial flora of patients with Sicca syndrome","volume":"18","author":"Zhou","year":"2018","journal-title":"Mol Med Rep"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13032"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.20411\/pai.v1i1.72"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199812)41:12<2175::AID-ART12>3.0.CO;2-I"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2011.01852.x"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.2174\/1389203715666140331113057"},{"key":"B41","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/9837035","article-title":"Bone morphogenetic protein 6 inhibits the immunomodulatory property of BMMSCs via Id1 in Sj\u00f6gren\u2019s syndrome","volume":"2018","author":"Su","year":"2018","journal-title":"Stem Cells Int"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2017.0161"},{"key":"B43","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.01406","article-title":"Monocyte-derived dendritic cell differentiation in inflammatory arthritis is regulated by the JAK\/STAT axis via NADPH oxidase regulation","volume":"11","author":"Marzaioli","year":"2020","journal-title":"Front Immunol"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1186\/ar4682"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1186\/ar3780"},{"key":"B46","article-title":"Activation of Myd88-dependent TLRs mediates local and systemic inflammation in a mouse model of primary Sj\u00f6gren\u2019s syndrome","volume":"10","author":"Kiripolsky","year":"2019","journal-title":"Front Immunol"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003093"},{"issue":"1","key":"B48","first-page":"24","article-title":"Immortalization of normal human salivary gland cells with duct-, myoepithelial-, acinar-, or squamous phenotype by transfection with SV40 ori- mutant deoxyribonucleic acid","volume":"69","author":"Azuma","year":"1993","journal-title":"Lab Invest"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt703"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-41695-z"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-019-1663-x"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3971"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/152780\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T17:42:15Z","timestamp":1691084535000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/152780"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,15]]},"references-count":52,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,3,15]]},"published-print":{"date-parts":[[2022,3,15]]}},"alternative-id":["10.1172\/JCI152780"],"URL":"https:\/\/doi.org\/10.1172\/jci152780","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,15]]},"article-number":"e152780"}}