{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:22:06Z","timestamp":1792077726478,"version":"4.4.0"},"reference-count":156,"publisher":"American Society for Clinical Investigation","issue":"8","license":[{"start":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T00:00:00Z","timestamp":1649980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,15]]},"DOI":"10.1172\/jci154943","type":"journal-article","created":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T14:00:55Z","timestamp":1649944855000},"source":"Crossref","is-referenced-by-count":233,"title":["Targeting mutations in cancer"],"prefix":"10.1172","volume":"132","author":[{"given":"Michael R.","family":"Waarts","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0602-1158","authenticated-orcid":false,"given":"Aaron J.","family":"Stonestrom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1018-4400","authenticated-orcid":false,"given":"Young C.","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross L.","family":"Levine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2022,4,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI83871"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genom-083115-022413"},{"issue":"1a","key":"B3","first-page":"A68","article-title":"The Cancer Genome Atlas (TCGA): an immeasurable source of knowledge","volume":"19","author":"Tomczak","year":"2015","journal-title":"Contemp Oncol (Pozn)"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2014.12.006"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1111\/cas.13837"},{"issue":"3","key":"B6","first-page":"256","article-title":"Cancer biomarker discovery and validation","volume":"4","author":"Goossens","year":"2015","journal-title":"Transl Cancer Res"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1186\/s40364-019-0178-7"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2015.10.021"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2559"},{"key":"B10","article-title":"Monoclonal antibodies in cancer therapy","volume":"12","author":"Scott","year":"2012","journal-title":"Cancer Immun"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/nri2744"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198810133191506"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1126\/science.2406902"},{"issue":"2 suppl 2","key":"B14","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1053\/shem.2003.50034","article-title":"Molecular mechanisms of transformation by the BCR-ABL oncogene","volume":"40","author":"Sattler","year":"2003","journal-title":"Semin Hematol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011573"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1609324"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(03)00979-3"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07679-1"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1126\/science.1062538"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V100.3.1014"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0912614"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1002315"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.38.7522"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1205127"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020009984"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b01040"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2019.08.004"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-03-011239"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210477"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-019-0069-2"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.16.2149"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.07.3585"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.44.2806"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30608-3"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1713137"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1913662"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1612674"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-17-2310"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0910383"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-005-0058-x"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1113216"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2020.7932"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-061516-121357"},{"issue":"5","key":"B44","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20051115","article-title":"HER2 directed antibody-drug-conjugates beyond T-DM1 in breast cancer","volume":"20","author":"Rinnerthaler","year":"2019","journal-title":"Int J Mol Sci"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.00662"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djk134"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2004.06.022"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.14.8957"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-0636"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2014-0465"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-2329"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1817323"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2020-0299"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30109-1"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-3060"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2015.426"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11101618"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0900780106"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.15.7636"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603291"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103782"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60868-X"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30142-6"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1038\/nature08833"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1105358"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2012-0333"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1412690"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1408868"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1908075"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6694"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-17-1452"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(83)90390-2"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1126\/science.1736363"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.22.14459"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204146"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.02903"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-15-0203"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b01153"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1917239"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1038\/nature12796"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-19-1167"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13010151"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.02.006"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2003.07.007"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1315226"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx289"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-05-850461"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30082-2"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1813904"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-0954-x"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30817-4"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-019-0754-1"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.60.1971"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-4152"},{"issue":"1","key":"B95","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nrc3181","article-title":"BRCA1 and BRCA2: different roles in a common pathway of genome protection","volume":"12","author":"Roy","year":"2011","journal-title":"Nat Rev Cancer"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt384"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1706450"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1611310"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32440-6"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1802905"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1909707"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-2753"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-13-0803"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-018-0274-8"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3934"},{"issue":"12","key":"B106","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20123100","article-title":"Identification of novel biomarkers of homologous recombination defect in DNA repair to predict sensitivity of prostate cancer cells to PARP-inhibitors","volume":"20","author":"Criscuolo","year":"2019","journal-title":"Int J Mol Sci"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1080\/14737159.2020.1701438"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-021-01295-z"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-021-00532-x"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03917-2"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1038\/nature18325"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.03.012"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210302"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5449.2507"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205362"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1038\/nm0302-282"},{"issue":"5","key":"B117","first-page":"411","article-title":"PRIMA-1MET inhibits growth of mouse tumors carrying mutant p53","volume":"30","author":"Zache","year":"2008","journal-title":"Cell Oncol"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.02341"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-3168"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2017.109"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-019-0095-0"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1038\/nature08617"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1126\/science.1170944"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2010.11.015"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-009-0561-9"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2010.12.014"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.7b00421"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-16-1034"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1126\/science.1234769"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1716984"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2017-0392"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0251-7"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-18-0877"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-16-0141"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.9b00509"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2010.311"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2013.04.011"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-11-321208"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1303800110"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-13-0773"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30441-1"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2020.04.004"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1516192"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201507978"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-018-0055-y"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-021-00346-0"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djz245"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201404913"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22625-y"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-021-01001-x"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr407"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1136\/esmoopen-2016-000094"},{"issue":"283","key":"B153","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaa7161","article-title":"Personalized genomic analyses for cancer mutation discovery and interpretation","volume":"7","author":"Jones","year":"2015","journal-title":"Sci Transl Med"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-39796-w"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0461-z"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2021.03.003"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/154943\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T13:43:07Z","timestamp":1691070187000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/154943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,15]]},"references-count":156,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2022,4,15]]},"published-print":{"date-parts":[[2022,4,15]]}},"alternative-id":["10.1172\/JCI154943"],"URL":"https:\/\/doi.org\/10.1172\/jci154943","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.742003133.793592985","asserted-by":"object"}]},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,15]]},"article-number":"e154943"}}