{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:07:11Z","timestamp":1791558431090,"version":"4.3.4"},"reference-count":69,"publisher":"American Society for Clinical Investigation","issue":"10","license":[{"start":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T00:00:00Z","timestamp":1652659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Neil and Leanne Petroff","award":["NA"],"award-info":[{"award-number":["NA"]}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","award":["143325"],"award-info":[{"award-number":["143325"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,16]]},"DOI":"10.1172\/jci156125","type":"journal-article","created":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T16:00:28Z","timestamp":1647964828000},"source":"Crossref","is-referenced-by-count":50,"title":["Aerobic exercise elicits clinical adaptations in myotonic dystrophy type 1 patients independently of pathophysiological changes"],"prefix":"10.1172","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8977-2055","authenticated-orcid":false,"given":"Andrew I.","family":"Mikhail","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7461-8415","authenticated-orcid":false,"given":"Peter L.","family":"Nagy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Manta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Rouse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Manta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean Y.","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael F.","family":"Nagy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0940-4314","authenticated-orcid":false,"given":"Paul","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1945-5569","authenticated-orcid":false,"given":"Jian-Qiang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua P.","family":"Nederveen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4592-4093","authenticated-orcid":false,"given":"Vladimir","family":"Ljubicic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0312-3746","authenticated-orcid":false,"given":"Mark A.","family":"Tarnopolsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2022,5,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.24240"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2014.04.011"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/355545a0"},{"issue":"7","key":"B4","doi-asserted-by":"crossref","first-page":"e1045","DOI":"10.1212\/WNL.0000000000011425","article-title":"Population-Based Prevalence of Myotonic Dystrophy Type 1 Using Genetic Analysis of Statewide Blood Screening Program","volume":"96","author":"Johnson","year":"2021","journal-title":"Neurology"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.128.6.995"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/10.19.2165"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.17.4439"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1126\/science.280.5364.737"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2007.07.027"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1101\/gr.184390.114"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-019-0019-2"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2018.02.010"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1113\/JP277123"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddy245"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awy231"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-020518-114310"},{"issue":"18","key":"B17","doi-asserted-by":"crossref","first-page":"4757","DOI":"10.1113\/JP278454","article-title":"Mechanisms of exercise-induced survival motor neuron expression in the skeletal muscle of spinal muscular atrophy-like mice","volume":"587","author":"Ng","year":"2019","journal-title":"J Physiol"},{"issue":"3\u20134","key":"B18","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1080\/21678421.2017.1404108","article-title":"A randomized controlled trial of resistance and endurance exercise in amyotrophic lateral sclerosis","volume":"19","author":"Clawson","year":"2018","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0000000000000088"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2018-0229"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-019-2458-7"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9993(96)90222-1"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.2340\/16501977-0833"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20460"},{"issue":"pt8","key":"B25","first-page":"1557","article-title":"Age and causes of death in adult-onset myotonic dystrophy","volume":"121","author":"Thijs","year":"1998","journal-title":"Brain"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200208-954OC"},{"issue":"6","key":"B27","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.18203\/2320-6012.ijrms20161760","article-title":"Effects of aerobic exercise on pulmonary function tests in healthy adults","volume":"4","author":"Angane","year":"2016","journal-title":"Int J Res Med Sci"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198507043130106"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(05)80189-9"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1556\/APhysiol.102.2015.1.1"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1172\/JCI64081"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.03.008"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13869-w"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.95"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2019.06.003"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-020-09970-6"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2021.03.024"},{"issue":"2","key":"B38","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1212\/WNL.0000000000011002","article-title":"Mexiletine in myotonic dystrophy type 1: a randomized, double-blind, placebo-controlled trial","volume":"96","author":"Heatwole","year":"2021","journal-title":"Neurology"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2020.08.001"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2018.12.002"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2020.02.015"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2020.03.004"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1038\/ng704"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.705822"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)00031-9"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2014.03.023"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gki698"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0083777"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.3109\/01658108909007466"},{"issue":"2\u20133","key":"B50","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0022-510X(86)90110-3","article-title":"\u201cRagged-red\u201d fibres in myotonic dystrophy","volume":"74","author":"Ono","year":"1986","journal-title":"J Neurol Sci"},{"issue":"1\u20132","key":"B51","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1159\/000213303","article-title":"Increased mitochondrial DNA deletions in the skeleal muscle of myotonic dystrophy","volume":"38","author":"Sahashi","year":"1992","journal-title":"Gerontology"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2017.10.007"},{"issue":"7","key":"B53","doi-asserted-by":"crossref","first-page":"6260","DOI":"10.18632\/aging.103022","article-title":"Myotonic Dystrophy type 1 cells display impaired metabolism and mitochondrial dysfunction that are reversed by metformin","volume":"12","author":"Garc\u00eda-puga","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtm.2021.09.007"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00605"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01136"},{"issue":"8","key":"B57","first-page":"783","article-title":"The six-minute walk test","volume":"48","author":"Enright","year":"2003","journal-title":"Respir Care"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/85.10.1034"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1991.tb01616.x"},{"issue":"5","key":"B60","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1002\/mus.21945","article-title":"Suction-modified Bergstr\u00f6m muscle biopsy technique: experience with 13,500 procedures","volume":"43","author":"Tarnopolsky","year":"2011","journal-title":"Muscle Nerve"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.3390\/nu12082391"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2019-0263"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-5-513"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-019-0201-4"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-019-1910-1"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu638"},{"issue":"12","key":"B67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-018-2486-6"},{"issue":"51","key":"B69","doi-asserted-by":"crossref","first-page":"E5593","DOI":"10.1073\/pnas.1419161111","article-title":"rMATS: robust and flexible detection of differential alternative splicing from replicate RNA-Seq data","volume":"111","author":"Shen","year":"2014","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/156125\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T04:32:33Z","timestamp":1700368353000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/156125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,16]]},"references-count":69,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,5,16]]},"published-print":{"date-parts":[[2022,5,16]]}},"alternative-id":["10.1172\/JCI156125"],"URL":"https:\/\/doi.org\/10.1172\/jci156125","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,16]]},"article-number":"e156125"}}