{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T02:15:51Z","timestamp":1791512151288,"version":"4.3.4"},"reference-count":42,"publisher":"American Society for Clinical Investigation","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Invest."],"published-print":{"date-parts":[[2002,10,15]]},"DOI":"10.1172\/jci0215693","type":"journal-article","created":{"date-parts":[[2013,3,22]],"date-time":"2013-03-22T15:36:27Z","timestamp":1363966587000},"page":"1093-1103","source":"Crossref","is-referenced-by-count":1225,"title":["Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine\/metabolic dysfunction of human congenital leptin deficiency"],"prefix":"10.1172","volume":"110","author":[{"given":"I. Sadaf","family":"Farooqi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Matarese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham M.","family":"Lord","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia M.","family":"Keogh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Lawrence","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chizo","family":"Agwu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Sanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan A.","family":"Jebb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Perna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Fontana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert I.","family":"Lechler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex M.","family":"DePaoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"O\u2019Rahilly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/372425a0"},{"key":"B2","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1210\/endo-98-6-1359","volume":"98","author":"Swerdloff","year":"1976","journal-title":"Endocrinology"},{"key":"B3","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1055\/s-0028-1095550","volume":"9","author":"Dubuc","year":"1977","journal-title":"Horm Metab Res"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/266060a0"},{"key":"B5","first-page":"110","volume":"233","author":"Ohtake","year":"1977","journal-title":"Am J Physiol"},{"key":"B6","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1152\/physrev.1971.51.3.598","volume":"51","author":"Bray","year":"1971","journal-title":"Physiol Rev"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/29795"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1126\/science.7624778"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1126\/science.7624777"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1126\/science.7624776"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/ng0396-318"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1210\/en.137.7.3144"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/43185"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909163411204"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19970021"},{"key":"B16","journal-title":""},{"key":"B17","first-page":"549","volume":"17","author":"Murgatroyd","year":"1993","journal-title":"Int J Obes Relat Metab Disord"},{"key":"B18","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1093\/ajcn\/35.5.1169","volume":"35","author":"Fomon","year":"1982","journal-title":"Am J Clin Nutr"},{"key":"B19","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1093\/ajcn\/32.3.607","volume":"32","author":"Hamill","year":"1979","journal-title":"Am J Clin Nutr"},{"key":"B20","doi-asserted-by":"crossref","first-page":"5909","DOI":"10.4049\/jimmunol.166.10.5909","volume":"166","author":"Matarese","year":"2001","journal-title":"J Immunol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.16.1568"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.47.4.538"},{"key":"B23","doi-asserted-by":"crossref","first-page":"247S","DOI":"10.1093\/ajcn\/56.1.247S","volume":"56(Suppl.)","author":"Franssila-Kallunki","year":"1992","journal-title":"Am J Clin Nutr"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.4.1550"},{"key":"B25","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1093\/ajcn\/71.5.1138","volume":"71","author":"Weinsier","year":"2000","journal-title":"Am J Clin Nutr"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1210\/en.140.8.3688"},{"key":"B27","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1017\/S0029665100000410","volume":"59","author":"Havel","year":"2000","journal-title":"Proc Nutr Soc"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1172\/JCI10741"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M003549200"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1210\/jc.87.5.2391"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.7.3284"},{"key":"B32","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1055\/s-2007-1009284","volume":"21","author":"Dubuc","year":"1989","journal-title":"Horm Metab Res"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/ng0398-213"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1210\/jc.84.10.3686"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/32911"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1210\/jc.82.4.1066"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1210\/en.138.2.855"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/382250a0"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012437"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(02)02188-9"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1172\/JCI6762"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1006\/cimm.1999.1594"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.jci.org\/articles\/view\/15693\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T12:46:40Z","timestamp":1691066800000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jci.org\/articles\/view\/15693"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,10,15]]},"references-count":42,"aliases":["10.1172\/jci200215693","10.1172\/jci15693"],"journal-issue":{"issue":"8","published-print":{"date-parts":[[2002,10,15]]}},"URL":"https:\/\/doi.org\/10.1172\/jci0215693","relation":{},"ISSN":["0021-9738"],"issn-type":[{"value":"0021-9738","type":"print"}],"subject":[],"published":{"date-parts":[[2002,10,15]]}}}