{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T01:40:38Z","timestamp":1790991638486,"version":"4.1.0"},"reference-count":49,"publisher":"American Society for Clinical Investigation","issue":"14","license":[{"start":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T00:00:00Z","timestamp":1657843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"crossref","award":["092805"],"award-info":[{"award-number":["092805"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"crossref","award":["202789"],"award-info":[{"award-number":["202789"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"crossref","award":["092805"],"award-info":[{"award-number":["092805"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"crossref","award":["202789"],"award-info":[{"award-number":["202789"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,15]]},"DOI":"10.1172\/jci158524","type":"journal-article","created":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T16:00:55Z","timestamp":1654617655000},"source":"Crossref","is-referenced-by-count":31,"title":["Schwann cell nodal membrane disruption triggers bystander axonal degeneration in a Guillain-Barr\u00e9 syndrome mouse model"],"prefix":"10.1172","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9571-2526","authenticated-orcid":false,"given":"Rhona","family":"McGonigal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare I.","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A.","family":"Barrie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3031-126X","authenticated-orcid":false,"given":"Denggao","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7545-6868","authenticated-orcid":false,"given":"Madeleine E.","family":"Cunningham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7154-5698","authenticated-orcid":false,"given":"Colin L.","family":"Crawford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2039-3457","authenticated-orcid":false,"given":"Simon","family":"Rinaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward G.","family":"Rowan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5997-1683","authenticated-orcid":false,"given":"Hugh J.","family":"Willison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2022,7,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00339-1"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.48.3.717"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2013.03.025"},{"issue":"pt 6","key":"B4","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1093\/brain\/109.6.1115","article-title":"An acute axonal form of Guillain-Barr\u00e9 polyneuropathy","volume":"109","author":"Feasby","year":"1986","journal-title":"Brain"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-01737-0"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/BF02284784"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410400414"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410390512"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2007.11.017"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410440210"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-8552-4_2"},{"key":"B12","article-title":"The role of gangliosides in the organisation of the node of Ranvier examined in glycosyltransferase transgenic mice","author":"McGonigal","journal-title":"J Anat"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20503"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4401-06.2007"},{"issue":"pt 9","key":"B15","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1093\/brain\/awh231","article-title":"Anti-disialoside antibodies kill perisynaptic Schwann cells and damage motor nerve terminals via membrane attack complex in a murine model of neuropathy","volume":"127","author":"Halstead","year":"2004","journal-title":"Brain"},{"issue":"pt 7","key":"B16","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1093\/brain\/awq119","article-title":"Anti-GD1a antibodies activate complement and calpain to injure distal motor nodes of Ranvier in mice","volume":"133","author":"McGonigal","year":"2010","journal-title":"Brain"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-020-00406-8"},{"key":"B18","article-title":"Real time imaging of intra-axonal calcium flux in an explant mouse model of axonal Guillain-Barr\u00e9 syndrome","author":"Cunningham","journal-title":"Exp Neurol"},{"issue":"pt 11","key":"B19","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1093\/brain\/awg254","article-title":"Calpain inhibitors protect against axonal degeneration in a model of anti-ganglioside antibody-mediated motor nerve terminal injury","volume":"126","author":"O\u2019Hanlon","year":"2003","journal-title":"Brain"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3996-13.2014"},{"key":"B21","doi-asserted-by":"crossref","DOI":"10.1186\/s40478-016-0291-x","article-title":"C1q-targeted inhibition of the classical complement pathway prevents injury in a novel mouse model of acute motor axonal neuropathy","volume":"4","author":"McGonigal","year":"2016","journal-title":"Acta Neuropathol Commun"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwl074"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20228"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3858"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-18-07025.1997"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.150.3.657"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2018.07.004"},{"issue":"pt 6","key":"B28","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1093\/brain\/aww056","article-title":"Anti-ganglioside antibodies are removed from circulation in mice by neuronal endocytosis","volume":"139","author":"Cunningham","year":"2016","journal-title":"Brain"},{"issue":"pt 5","key":"B29","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1093\/brain\/124.5.893","article-title":"Anti-GQ1b ganglioside antibodies mediate complement-dependent destruction of the motor nerve terminal","volume":"124","author":"O\u2019Hanlon","year":"2001","journal-title":"Brain"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2008.05.028"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1111\/jns.12373"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a020503"},{"key":"B33","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2020.135595","article-title":"New evidence for secondary axonal degeneration in demyelinating neuropathies","volume":"744","author":"Moss","year":"2021","journal-title":"Neurosci Lett"},{"issue":"1","key":"B34","doi-asserted-by":"crossref","first-page":"246","DOI":"10.4049\/jimmunol.138.1.246","article-title":"Recovery of human neutrophils from complement attack: removal of the membrane attack complex by endocytosis and exocytosis","volume":"138","author":"Morgan","year":"1987","journal-title":"J Immunol"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2013.08.010"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2339-09.2009"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4662-13.2014"},{"key":"B38","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2017.00011","article-title":"Postnatal loss of neuronal and glial neurofascins differentially affects node of Ranvier maintenance and myelinated axon function","volume":"11","author":"Taylor","year":"2017","journal-title":"Front Cell Neurosci"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1015-11.2011"},{"key":"B40","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.21392","article-title":"The paranodal cytoskeleton clusters Na+ channels at nodes of Ranvier","volume":"6","author":"Amor","year":"2017","journal-title":"Elife"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00294-X"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00296-3"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.22015"},{"key":"B44","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms6683","article-title":"A recoverable state of axon injury persists for hours after spinal cord contusion in vivo","volume":"5","author":"Williams","year":"2014","journal-title":"Nat Commun"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.12.023"},{"issue":"pt 1","key":"B46","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1093\/brain\/awn281","article-title":"Disruption of neurofascin and gliomedin at nodes of Ranvier precedes demyelination in experimental allergic neuritis","volume":"132","author":"Lonigro","year":"2009","journal-title":"Brain"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1172\/JCI37338"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1991.tb12275.x"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1007\/BF01262657"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/158524\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T17:44:45Z","timestamp":1691084685000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/158524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,15]]},"references-count":49,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2022,7,15]]},"published-print":{"date-parts":[[2022,7,15]]}},"alternative-id":["10.1172\/JCI158524"],"URL":"https:\/\/doi.org\/10.1172\/jci158524","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,15]]},"article-number":"e158524"}}