{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T06:05:22Z","timestamp":1792821922603,"version":"4.5.0"},"reference-count":68,"publisher":"American Society for Clinical Investigation","issue":"2","license":[{"start":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T00:00:00Z","timestamp":1673913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01 AI139675,R01 AI030048,P50CA217691,P50CA206963,P01AI056299"],"award-info":[{"award-number":["R01 AI139675,R01 AI030048,P50CA217691,P50CA206963,P01AI056299"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,17]]},"DOI":"10.1172\/jci160025","type":"journal-article","created":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T17:00:51Z","timestamp":1668531651000},"source":"Crossref","is-referenced-by-count":97,"title":["mTOR regulates T cell exhaustion and PD-1\u2013targeted immunotherapy response during chronic viral infection"],"prefix":"10.1172","volume":"133","author":[{"given":"Satomi","family":"Ando","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles M.","family":"Perkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamato","family":"Sajiki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chase","family":"Chastain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh M.","family":"Valanparambil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9648-7922","authenticated-orcid":false,"given":"Andreas","family":"Wieland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2513-1213","authenticated-orcid":false,"given":"William H.","family":"Hudson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7120-1390","authenticated-orcid":false,"given":"Masao","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0757-3106","authenticated-orcid":false,"given":"Suresh S.","family":"Ramalingam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7210-5616","authenticated-orcid":false,"given":"Gordon J.","family":"Freeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafi","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Araki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2023,1,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-022-01224-z"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2021.101480"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-021-00949-7"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-019-0235-4"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/nature04444"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/nature19330"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/nature19317"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.07.021"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aai8593"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-021-00975-5"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.04.014"},{"issue":"7930","key":"B12","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/s41586-022-05257-0","article-title":"PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program","volume":"CD8","author":"Hashimoto","year":"2022","journal-title":"Nature"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20180684"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1836-5"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0312-6"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.10.038"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.12.021"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03862-z"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.11.002"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.10.009"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-0219-y"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.04.013"},{"issue":"7","key":"B23","doi-asserted-by":"crossref","DOI":"10.1111\/petr.14077","article-title":"Induction and maintenance immunosuppression in pediatric kidney transplantation-Advances and controversies","volume":"25","author":"Balani","year":"2021","journal-title":"Pediatr Transplant"},{"issue":"3","key":"B24","doi-asserted-by":"crossref","DOI":"10.1111\/tid.13267","article-title":"Infections after kidney transplantation: A comparison of mTOR-Is and CNIs as basic immunosuppressants. A systematic review and meta-analysis","volume":"22","author":"Wolf","year":"2020","journal-title":"Transpl Infect Dis"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2741"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.06.005"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1172\/JCI86504"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1701321"},{"issue":"4","key":"B29","doi-asserted-by":"crossref","first-page":"e01653","DOI":"10.1128\/JVI.01653-16","article-title":"mTOR promotes anti-viral humoral immunity by differentially regulating CD4 helper T cell and B cell responses","volume":"91","author":"Ye","year":"2017","journal-title":"J Virol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201767"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/nature08155"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/nature08097"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.06.007"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.10.013"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-020-05435-1"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105463"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-020-00396-1"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001176"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09234-6"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.26.12574"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90570-3"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1038\/369756a0"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.06.014"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3795"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12030738"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-021-00459-7"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-019-0297-y"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.878209"},{"issue":"3","key":"B49","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1097\/TP.0000000000003851","article-title":"T-cell exhaustion in organ transplantation","volume":"106","author":"Angeletti","year":"2021","journal-title":"Transplantation"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2019.01.040"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31816dd64a"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15870"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.68.12.8056-8063.1994"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.8.4911-4927.2003"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1084\/jem.160.2.521"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky379"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3317"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt656"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"B60","first-page":"2825","article-title":"Scikit-learn: machine learning in python","volume":"12","author":"Pedregosa","year":"2011","journal-title":"J Mach Learn Res"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1038\/ng1180"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.1.27"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1002\/pro.3715"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa970"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2015.12.004"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-430-8_19"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80470-7"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/160025\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T17:45:15Z","timestamp":1691084715000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/160025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,17]]},"references-count":68,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,1,17]]},"published-print":{"date-parts":[[2023,1,17]]}},"alternative-id":["10.1172\/JCI160025"],"URL":"https:\/\/doi.org\/10.1172\/jci160025","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,17]]},"article-number":"e160025"}}