{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:12:30Z","timestamp":1789567950667,"version":"build-2803163510"},"reference-count":28,"publisher":"American Society for Clinical Investigation","issue":"1","license":[{"start":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T00:00:00Z","timestamp":1672704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Berstein Foundation","award":["1"],"award-info":[{"award-number":["1"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["P30-AR069589,R01AR079483"],"award-info":[{"award-number":["P30-AR069589,R01AR079483"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"crossref","award":["I01RX002701"],"award-info":[{"award-number":["I01RX002701"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Moseley Foundation","award":["1"],"award-info":[{"award-number":["1"]}]},{"name":"H.T. Leung Foundation","award":["1"],"award-info":[{"award-number":["1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,3]]},"DOI":"10.1172\/jci162137","type":"journal-article","created":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T17:00:45Z","timestamp":1668099645000},"source":"Crossref","is-referenced-by-count":18,"title":["Identification of a neutrophil-specific PIK3R1 mutation facilitates targeted treatment in a patient with Sweet syndrome"],"prefix":"10.1172","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4248-2362","authenticated-orcid":false,"given":"Shreya","family":"Bhattacharya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayon","family":"Basu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6058-1113","authenticated-orcid":false,"given":"Emily","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna E.","family":"Kersh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline A.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9201-9830","authenticated-orcid":false,"given":"Joshua S.","family":"Bryer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hovik A.","family":"Ashchyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Steele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Forrestel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0383-031X","authenticated-orcid":false,"given":"John T.","family":"Seykora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2517-7008","authenticated-orcid":false,"given":"Robert G.","family":"Micheletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D.","family":"James","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misha","family":"Rosenbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1086-0824","authenticated-orcid":false,"given":"Thomas H.","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2023,1,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-2-34"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.11.064"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.09.013"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00414"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgg.2015.03.003"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.06.009"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-018-4957-6"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(92)80909-Z"},{"key":"B9","first-page":"417","article-title":"Activation of neutrophils by interleukins-1 and -2 and tumor necrosis factors","volume":"57","author":"Ferrante","year":"1992","journal-title":"Immunol Ser"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-007-9047-x"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1080\/00365520310008610"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2003.12.018"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1172\/JCI75746"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-11-0039"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2013.06.005"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.07.029"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1902"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20141759"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.673453"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.10.054"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2021.10.015"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00475"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1214514"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-02-205690"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.068254"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(98)70266-X"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1159\/000326112"},{"issue":"4","key":"B28","article-title":"Refractory sweet syndrome treated with anakinra","volume":"11","author":"Shahid","year":"2019","journal-title":"Cureus"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/162137\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T17:45:53Z","timestamp":1691084753000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/162137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,3]]},"references-count":28,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1,3]]},"published-print":{"date-parts":[[2023,1,3]]}},"alternative-id":["10.1172\/JCI162137"],"URL":"https:\/\/doi.org\/10.1172\/jci162137","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,3]]},"article-number":"e162137"}}