{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T19:29:55Z","timestamp":1793820595670,"version":"4.6.1"},"reference-count":146,"publisher":"American Society for Clinical Investigation","issue":"18","license":[{"start":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T00:00:00Z","timestamp":1663200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,15]]},"DOI":"10.1172\/jci162480","type":"journal-article","created":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T14:00:59Z","timestamp":1663164059000},"source":"Crossref","is-referenced-by-count":186,"title":["Von Hippel\u2013Lindau disease: insights into oxygen sensing, protein degradation, and cancer"],"prefix":"10.1172","volume":"132","author":[{"suffix":"Jr.","given":"William G.","family":"Kaelin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2022,9,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199711000-00001"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21654"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/nrc885"},{"issue":"24","key":"B4","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1200\/JCO.2004.05.061","article-title":"Role of VHL gene mutation in human cancer","volume":"22","author":"Kim","year":"2004","journal-title":"J Clin Oncol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2017.01.009"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-014-0167-x"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.20.11661"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1202473"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.15.8817"},{"issue":"18","key":"B10","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/nm0895-822","article-title":"Tumor suppression by the human von Hippel-Lindau gene product","volume":"1","author":"Iliopoulos","year":"1995","journal-title":"Nat Med"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.19.2.1486"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.5.1770"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad5755"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2007.09.010"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2008.04.009"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1126\/science.1059817"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.192342099"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1126\/science.1059796"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00507-4"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.181341498"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1126\/science.1066373"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg392"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00331-09"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2502"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/10.10.1019"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/10.10.1029"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(02)00071-5"},{"issue":"3","key":"B28","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1371\/journal.pbio.0000083","article-title":"Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth","volume":"1","author":"Kondo","year":"2003","journal-title":"PLoS Biol"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(02)00043-0"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.89.2.2"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.13.5675-5686.2005"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2007.02.006"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(02)00044-2"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-11-0098"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2120403119"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/nature19795"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1038\/ng.723"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2005.06.015"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00282-07"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.16.8761"},{"key":"B41"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1619726114"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.02.074"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2013.10.025"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.17.9102"},{"issue":"17","key":"B46","first-page":"5320","article-title":"Hepatic vascular tumors, angiectasis in multiple organs, and impaired spermatogenesis in mice with conditional inactivation of the VHL gene","volume":"63","author":"Ma","year":"2003","journal-title":"Cancer Res"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-3241"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.8.3163-3172.2005"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2008.160"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601300"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1414789111"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-1859"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-1745"},{"issue":"4","key":"B54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-018-0059-4","article-title":"Generation of autochthonous mouse models of clear cell renal cell carcinoma: mouse models of renal cell carcinoma","volume":"50","author":"Hou","year":"2018","journal-title":"Exp Mol Med"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15770"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-17-0292"},{"issue":"12","key":"B57","first-page":"3879","article-title":"von Hippel-Lindau mutation in mice recapitulates Chuvash polycythemia via hypoxia-inducible factor-2alpha signaling and splenic erythropoiesis","volume":"117","author":"Hickey","year":"2007","journal-title":"J Clin Invest"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-1093-z"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(02)01159-4"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr011"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1021\/jm301847z"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1185"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0808092106"},{"issue":"7627","key":"B64","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nature19796","article-title":"Targeting renal cell carcinoma with a HIF-2 antagonist","volume":"359","author":"Chen","year":"2016","journal-title":"Nature"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-16-0473"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2103425"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01324-7"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2110051"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1038\/s41585-020-0282-3"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2013.05.008"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.4.4.455"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.12.033"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1038\/nature12213"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.121522"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1172\/JCI121476"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2021.10.001"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.137569"},{"issue":"3","key":"B78","first-page":"1099","article-title":"Regression of human kidney cancer following allogeneic stem cell transplantation is associated with recognition of an HERV-E antigen by T cells","volume":"118","author":"Takahashi","year":"2008","journal-title":"J Clin Invest"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-3139"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2011.179"},{"issue":"3","key":"B81","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2001-2-3-research0007","article-title":"The DNA-repair protein AlkB, EGL-9, and leprecan define new families of 2-oxoglutarate- and iron-dependent dioxygenases","volume":"2","author":"Aravind","year":"2001","journal-title":"Genome Biol"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-020-00303-3"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw1026"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau5870"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1101\/gad.217406.113"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1112317108"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2010.11.015"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1126\/science.1231677"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1038\/nature10898"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4423"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-010-0790-y"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(03)00194-6"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2015.11.006"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-21-0611"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1126\/science.1236062"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-16-0141"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1038\/nature16490"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2016.12.011"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b01686"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1039\/C7SC02103H"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.758516"},{"issue":"3","key":"B102","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1093\/cvr\/cvm035","article-title":"Complete loss of ischaemic preconditioning-induced cardioprotection in mice with partial deficiency of HIF-1 alpha","volume":"77","author":"Cai","year":"2008","journal-title":"Cardiovasc Res"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.02.006"},{"issue":"1\u20132","key":"B104","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s11010-008-9717-5","article-title":"Remote renal preconditioning-induced cardioprotection: a key role of hypoxia inducible factor-prolyl 4-hydroxylases","volume":"312","author":"Kant","year":"2008","journal-title":"Mol Cell Biochem"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-007-0283-1"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.2870"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2015.193"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.922427"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0011693"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00166-09"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1413579"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1413534"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-19-07463.2001"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05540.x"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2009.06.003"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2016.04.038"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M603503200"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfq024"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2020.07.017"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1126\/science.abm1638"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-019-0047-y"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.11.031"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1126\/science.1177319"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.119"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-05-356063"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12338"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-06-438101"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1126\/science.1244917"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1126\/science.1244851"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12708"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-018-0129-x"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.38430"},{"issue":"6336","key":"B133","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1126\/science.aal3755","article-title":"Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15","volume":"356","author":"Han","year":"2017","journal-title":"Science"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2363"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.59994"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2374-x"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1126\/science.aab1433"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2015.05.009"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.11.006"},{"issue":"11","key":"B140","first-page":"3014","article-title":"VHL-mediated hypoxia regulation of cyclin D1 in renal carcinoma cells","volume":"62","author":"Bindra","year":"2002","journal-title":"Cancer Res"},{"issue":"1","key":"B141","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201846401","article-title":"Inherent DNA-binding specificities of the HIF-1\u03b1 and HIF-2\u03b1 transcription factors in chromatin","volume":"20","author":"Smythies","year":"2019","journal-title":"EMBO Rep"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-10-314427"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1515\/hsz-2012-0351"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-4564"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc8479"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1016\/j.jash.2018.03.008"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/162480\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T13:46:10Z","timestamp":1691070370000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/162480"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,15]]},"references-count":146,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2022,9,15]]},"published-print":{"date-parts":[[2022,9,15]]}},"alternative-id":["10.1172\/JCI162480"],"URL":"https:\/\/doi.org\/10.1172\/jci162480","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,15]]},"article-number":"e162480"}}