{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T06:08:13Z","timestamp":1793254093824,"version":"4.5.0"},"reference-count":54,"publisher":"American Society for Clinical Investigation","issue":"8","license":[{"start":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T00:00:00Z","timestamp":1681689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"crossref","award":["AG062413,AG076515,AG068048,AG013925,AG063543,AG056278,AG063707"],"award-info":[{"award-number":["AG062413,AG076515,AG068048,AG013925,AG063543,AG056278,AG063707"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"crossref","award":["DK128552"],"award-info":[{"award-number":["DK128552"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Cancer Institute","award":["UG3CA26810"],"award-info":[{"award-number":["UG3CA26810"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,17]]},"DOI":"10.1172\/jci162519","type":"journal-article","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T12:00:57Z","timestamp":1676980857000},"source":"Crossref","is-referenced-by-count":79,"title":["Local senolysis in aged mice only partially replicates the benefits of systemic senolysis"],"prefix":"10.1172","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3179-6414","authenticated-orcid":false,"given":"Joshua N.","family":"Farr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0673-3710","authenticated-orcid":false,"given":"Dominik","family":"Saul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0912-0095","authenticated-orcid":false,"given":"Madison L.","family":"Doolittle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Japneet","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Rowsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie J.","family":"Vos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell N.","family":"Froemming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony B.","family":"Lagnado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3876-3156","authenticated-orcid":false,"given":"Yi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Weivoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Ikeno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Pignolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1074-1385","authenticated-orcid":false,"given":"Laura J.","family":"Niedernhofer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul D.","family":"Robbins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4486-0857","authenticated-orcid":false,"given":"Diana","family":"Jurk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8765-1890","authenticated-orcid":false,"given":"Jo\u00e3o F.","family":"Passos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2002-0418","authenticated-orcid":false,"given":"Nathan K.","family":"LeBrasseur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Tchkonia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James L.","family":"Kirkland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4818-0114","authenticated-orcid":false,"given":"David G.","family":"Monroe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2936-4372","authenticated-orcid":false,"given":"Sundeep","family":"Khosla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2023,4,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0457-8"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2014-006413"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1377\/hlthaff.2013.0052"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2012.11.014"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.05.039"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.10.039"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-016-9954-6"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-020-0335-y"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/nature10600"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.12997"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12344"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2017.04.013"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.320"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.548"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021119-034332"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2022.03.011"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-020-00619-x"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.24.13742"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg417"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1172\/JCI22475"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb3420"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.69958"},{"issue":"5","key":"B23","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13602","article-title":"Targeted clearance of p21- but not p16-positive senescent cells prevents radiation-induced osteoporosis and increased marrow adiposity","volume":"21","author":"Chandra","year":"2022","journal-title":"Aging Cell"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1708"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.93771"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2892"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4385"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2019.01.015"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/nm1262"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/23.24.5080"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.12.5860"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djq364"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.02.031"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2012.09.040"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.70817"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1101\/SQB.1997.062.01.021"},{"issue":"9","key":"B37","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020106048","article-title":"Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner","volume":"40","author":"Lagnado","year":"2021","journal-title":"EMBO J"},{"issue":"10","key":"B38","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.18632\/aging.101308","article-title":"Degeneration of the osteocyte network in the C57BL\/6 mouse model of aging","volume":"9","author":"Tiede-Lewis","year":"2017","journal-title":"Aging (Albany NY)"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32552-1"},{"issue":"46","key":"B40","doi-asserted-by":"crossref","first-page":"E6301","DOI":"10.1073\/pnas.1515386112","article-title":"JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age","volume":"112","author":"Xu","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"B41","first-page":"780","article-title":"Transplanted senescent cells induce an osteoarthritis-like condition in mice","volume":"72","author":"Xu","year":"2017","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0092-9"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-0816"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e07-03-0280"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2011504117"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2017.07.033"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2012.00795.x"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2017.08.005"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M108278200"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1019507108"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.135236"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp098"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-9-488"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-14-128"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/162519\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T13:46:12Z","timestamp":1691070372000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/162519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,17]]},"references-count":54,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2023,4,17]]},"published-print":{"date-parts":[[2023,4,17]]}},"alternative-id":["10.1172\/JCI162519"],"URL":"https:\/\/doi.org\/10.1172\/jci162519","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,17]]},"article-number":"e162519"}}