{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:59:30Z","timestamp":1792598370029,"version":"4.5.0"},"reference-count":93,"publisher":"American Society for Clinical Investigation","issue":"12","license":[{"start":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T00:00:00Z","timestamp":1686787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"crossref","award":["C16\/17\/010"],"award-info":[{"award-number":["C16\/17\/010"]}],"id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"crossref"}]},{"name":"(FAPESP) under grant 22 agreements","award":["2020\/04860-8"],"award-info":[{"award-number":["2020\/04860-8"]}]},{"name":"Center for Research in Inflammatory Disease","award":["2013\/08216-2"],"award-info":[{"award-number":["2013\/08216-2"]}]},{"name":"FAPESP and Research Foundation Flanders","award":["grant G0F7519N - 18\/10990-1"],"award-info":[{"award-number":["grant G0F7519N - 18\/10990-1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,15]]},"DOI":"10.1172\/jci163105","type":"journal-article","created":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T12:01:07Z","timestamp":1682596867000},"source":"Crossref","is-referenced-by-count":40,"title":["C5aR1 signaling triggers lung immunopathology in COVID-19 through neutrophil extracellular traps"],"prefix":"10.1172","volume":"133","author":[{"given":"Bruna M.","family":"Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4855-3056","authenticated-orcid":false,"given":"Giovanni F.","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6222-4064","authenticated-orcid":false,"given":"Flavio P.","family":"Veras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9996-1511","authenticated-orcid":false,"given":"Seppe","family":"Cambier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4435-659X","authenticated-orcid":false,"given":"Gabriel V.L.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreza U.","family":"Quadros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3916-6748","authenticated-orcid":false,"given":"Diego B.","family":"Caetit\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0620-339X","authenticated-orcid":false,"given":"Daniele C.","family":"Nascimento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla M.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana C.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0215-4420","authenticated-orcid":false,"given":"Samara","family":"Damasceno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayda H.","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9369-2525","authenticated-orcid":false,"given":"Fabio","family":"Beretta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9694-3489","authenticated-orcid":false,"given":"Sabrina S.","family":"Batah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3484-8718","authenticated-orcid":false,"given":"Icaro M.S.","family":"Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2741-150X","authenticated-orcid":false,"given":"Isadora M.","family":"Paiva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4968-5384","authenticated-orcid":false,"given":"Tamara","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Salina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8902-5962","authenticated-orcid":false,"given":"Ronaldo","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme C.M.","family":"Cebinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2052-2992","authenticated-orcid":false,"given":"Naira L.","family":"Bibo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel M.","family":"Jorge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helder I.","family":"Nakaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7856-7512","authenticated-orcid":false,"given":"Dario S.","family":"Zamboni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9483-3705","authenticated-orcid":false,"given":"Luiz O.","family":"Leiria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre T.","family":"Fabro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9918-8714","authenticated-orcid":false,"given":"Jos\u00e9 C.","family":"Alves-Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0978-410X","authenticated-orcid":false,"given":"Eurico","family":"Arruda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2585-3870","authenticated-orcid":false,"given":"Paulo","family":"Louzada-Junior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00ea D.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1290-0263","authenticated-orcid":false,"given":"Larissa D.","family":"Cunha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Van Mol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3364-1213","authenticated-orcid":false,"given":"Lore","family":"Vanderbeke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7516-9471","authenticated-orcid":false,"given":"Simon","family":"Feys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0115-0030","authenticated-orcid":false,"given":"Els","family":"Wauters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5959-4443","authenticated-orcid":false,"given":"Laura","family":"Brandolini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Aramini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Q.","family":"Cunha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1121-3178","authenticated-orcid":false,"given":"J\u00f6rg","family":"K\u00f6hl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0617-0233","authenticated-orcid":false,"given":"Marcello","family":"Allegretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diether","family":"Lambrechts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5983-3897","authenticated-orcid":false,"given":"Joost","family":"Wauters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0133-5545","authenticated-orcid":false,"given":"Paul","family":"Proost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1084-0065","authenticated-orcid":false,"given":"Thiago M.","family":"Cunha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2023,6,15]]},"reference":[{"issue":"3","key":"B1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41579-020-00459-7","article-title":"Characteristics of SARS-CoV-2 and COVID-19","volume":"19","author":"Hu","year":"2021","journal-title":"Nat Rev Microbiol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp2009575"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-1051-9"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abm5505"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01643-9"},{"key":"B6","article-title":"Effects of tocilizumab on adults with COVID-19 pneumonia: a meta-analysis","volume":"9","author":"Chen","year":"2022","journal-title":"Front Med (lausanne)"},{"issue":"3","key":"B7","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1159\/000519090","article-title":"ESCAPE: an open-label trial of personalized immunotherapy in critically lll COVID-19 patients","volume":"71","author":"Karakike","year":"2021","journal-title":"J Innate Immun"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-99291-z"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.11330"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2021436"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00665-1"},{"key":"B12","article-title":"Complement activation in COVID-19 and targeted therapeutic options: a scoping review","volume":"57","author":"Lim","year":"2022","journal-title":"Blood Rev"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3390\/biom12020226"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.12.040194.004015"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2478(03)00052-X"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.624025"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2018.03.002"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118818"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2018.03.029"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-15471-w"},{"issue":"5","key":"B21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0064443","article-title":"Complement C5 activation during influenza A infection in mice contributes to neutrophil recruitment and lung injury","volume":"8","author":"Garcia","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"B22","doi-asserted-by":"crossref","DOI":"10.1038\/s41426-018-0063-8","article-title":"Blockade of the C5a-C5aR axis alleviates lung damage in hDPP4-transgenic mice infected with MERS-CoV","volume":"7","author":"Jiang","year":"2018","journal-title":"Emerg Microbes Infect"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2600-6"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.05.006"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-022-02126-2"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2022.09.003"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1111\/cts.13213"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(22)00297-1"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.155055"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2020.09.008"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-00455-9"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-022-00534-7"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0901-9"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24360-w"},{"issue":"3","key":"B35","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/SHK.0000000000001740","article-title":"Immunopathological Roles of Neutrophils in Virus Infection and COVID-19","volume":"56","author":"Cui","year":"2021","journal-title":"Shock"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20201000"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0778-2"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2943-z"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.2c00091"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.2c02794"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1417365111"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200202114"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20201129"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-021-00805-z"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1096\/fj.15-271635"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-023-02336-2"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.17021"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2030340"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01499-z"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2020-001455"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2100433"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2010540117"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfaa192"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2020.102560"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1007\/s00430-021-00725-2"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13585"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.835156"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abl9929"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1177\/03009858211066841"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.3390\/v13010132"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2021.03.038"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021005246"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2200960119"},{"issue":"10","key":"B64","doi-asserted-by":"crossref","DOI":"10.1099\/jgv.0.001667","article-title":"MERS-CoV infection causes brain damage in human DPP4-transgenic mice through complement-mediated inflammation","volume":"102","author":"Jiang","year":"2021","journal-title":"J Gen Virol"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abd6832"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700393"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1038\/nri1269"},{"issue":"1","key":"B68","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/j.1749-6632.1991.tb33132.x","article-title":"Molecular cloning of the human neurokinin-2 receptor cDNA by polymerase chain reaction and isolation of the gene","volume":"632","author":"Gerard","year":"1991","journal-title":"Ann N Y Acad Sci"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcibr022995"},{"issue":"46","key":"B70","doi-asserted-by":"crossref","first-page":"E3177","DOI":"10.1073\/pnas.1213797109","article-title":"Neutrophils orchestrate their own recruitment in murine arthritis through C5aR and Fc\u03b3R signaling","volume":"109","author":"Sadik","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aaj2195"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0132703"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0173257"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20200652"},{"issue":"11","key":"B75","article-title":"Neutrophil extracellular traps in COVID-19","volume":"5","author":"Zuo","year":"2020","journal-title":"JCI Insight"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020007008"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1172\/JCI141374"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01618"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.636954"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2015.08.018"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M208359200"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(21)00237-8"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-021-03672-9"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-021-03717-z"},{"issue":"1","key":"B85","first-page":"162","article-title":"Dexamethasone therapy and rates of secondary pulmonary and bloodstream infections in critically ill COVID-19 patients","volume":"16","author":"Rothe","year":"2021","journal-title":"Multidiscip Respir Med"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy958"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020002497"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2014.136"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000001531"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1038\/nm1753"},{"issue":"1","key":"B91","doi-asserted-by":"crossref","first-page":"e01755","DOI":"10.1128\/mBio.01755-17","article-title":"Complement C5a receptor 1 exacerbates the pathophysiology of N. meningitidis sepsis and is a potential target for disease treatment","volume":"9","author":"Herrmann","year":"2018","journal-title":"mBio"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1401401"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1111\/his.14160"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/163105\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T11:24:05Z","timestamp":1702293845000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/163105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,15]]},"references-count":93,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023,6,15]]},"published-print":{"date-parts":[[2023,6,15]]}},"alternative-id":["10.1172\/JCI163105"],"URL":"https:\/\/doi.org\/10.1172\/jci163105","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.07.03.498624","asserted-by":"object"}]},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,15]]},"article-number":"e163105"}}