{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T18:02:25Z","timestamp":1789322545157,"version":"build-2803163510"},"reference-count":64,"publisher":"American Society for Clinical Investigation","issue":"12","license":[{"start":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T00:00:00Z","timestamp":1686787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"crossref","award":["R01CA195651"],"award-info":[{"award-number":["R01CA195651"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"crossref","award":["R01CA196941"],"award-info":[{"award-number":["R01CA196941"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"crossref","award":["P01CA117969"],"award-info":[{"award-number":["P01CA117969"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"crossref","award":["P50CA221707"],"award-info":[{"award-number":["P50CA221707"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,15]]},"DOI":"10.1172\/jci163873","type":"journal-article","created":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T16:00:41Z","timestamp":1683216041000},"source":"Crossref","is-referenced-by-count":4,"title":["Hematopoietic progenitor kinase 1 inhibits the development and progression of pancreatic intraepithelial neoplasia"],"prefix":"10.1172","volume":"133","author":[{"given":"Hua","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5909-7375","authenticated-orcid":false,"given":"Rohan","family":"Moniruzzaman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8971-1463","authenticated-orcid":false,"given":"Baoan","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9748-0650","authenticated-orcid":false,"given":"Yi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangsheng","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0904-6489","authenticated-orcid":false,"given":"Reza","family":"Abbasgholizadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangchao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiqi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4969-3170","authenticated-orcid":false,"given":"Tse-Hua","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7923-9978","authenticated-orcid":false,"given":"Anirban","family":"Maitra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2038-5863","authenticated-orcid":false,"given":"Huamin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2023,6,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.12"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2019-0477-RA"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26651"},{"issue":"6","key":"B4","first-page":"1547","article-title":"K-ras mutations in pancreatic ductal proliferative lesions","volume":"145","author":"Klimstra","year":"1994","journal-title":"Am J Pathol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.32.19925"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2008.10.010"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.05.052"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.08.018"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-0718"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.01.071"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.01.058"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.357"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-12-0231"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3390\/genes12050662"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-021-02040-9"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1101\/gad.10.18.2251"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1996.tb01093.x"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/ni1416"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2020.08.001"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.09.012"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0212670"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0243145"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2020-001402"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e318215c3fb"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-1751"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.7131"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.520106"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA119.012186"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2015.09.004"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.20411"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.44.27804"},{"issue":"1\u20132","key":"B32","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1159\/000015058","article-title":"Assignment of IkappaB kinase beta (IKBKB) to human chromosome band 8p12-->p11 by in situ hybridization","volume":"82","author":"Shindo","year":"1998","journal-title":"Cytogenet Cell Genet"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2005.05.015"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(03)00309-X"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2005.04.023"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2007.01.012"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2007.01.017"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2007.08.002"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1158703"},{"issue":"9","key":"B40","first-page":"2005","article-title":"The mutant K-ras oncogene causes pancreatic periductal lymphocytic infiltration and gastric mucous neck cell hyperplasia in transgenic mice","volume":"63","author":"Brembeck","year":"2003","journal-title":"Cancer Res"},{"issue":"9","key":"B41","first-page":"2016","article-title":"Preinvasive pancreatic neoplasia of ductal phenotype induced by acinar cell targeting of mutant Kras in transgenic mice","volume":"63","author":"Grippo","year":"2003","journal-title":"Cancer Res"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-2305"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0810097105"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.03.068"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2009.09.027"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2011.05.011"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1172\/JCI40045"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-022-01134-8"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.12.008"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012468"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(00)00089-3"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2019.10.007"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1908353116"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.619"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2009.07.040"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20000601)88:11<2495::AID-CNCR10>3.0.CO;2-B"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v110.pm8536861"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb09525.x"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts635"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1101\/gr.135350.111"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.2307\/2346101"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"issue":"78","key":"B64","doi-asserted-by":"crossref","DOI":"10.3791\/50514-v","article-title":"Isolation and culture of mouse primary pancreatic acinar cells","author":"Gout","year":"2013","journal-title":"J Vis Exp"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/163873\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T17:46:59Z","timestamp":1691084819000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/163873"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,15]]},"references-count":64,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023,6,15]]},"published-print":{"date-parts":[[2023,6,15]]}},"alternative-id":["10.1172\/JCI163873"],"URL":"https:\/\/doi.org\/10.1172\/jci163873","relation":{},"ISSN":["1558-8238"],"issn-type":[{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,15]]},"article-number":"e163873"}}